Researchers have documented glycan-glycan interactions between gangliosides and their impact on EGF receptor dimerization and activation. This study provides a new mechanism regulating EGFR activity, which may have implications for future cancer research.
Researchers have uncovered the molecular 'gate' for bulky cargo in bacteria, allowing it to safely transport large proteins across cell membranes. The Tat system, essential for metabolism and virulence, may serve as a potential target for antimicrobial interventions.
A study published in Science Advances reveals that neuronal hyperactivity triggered by rogue antibodies is a key driver of the severe autoimmune brain disorder IgLON5 encephalitis. The research also highlights similarities between this condition and Alzheimer's disease, suggesting potential therapeutic targets.
Scientists at Stockholm University and SciLifeLab have uncovered a crucial missing link in how sugar transporters move nutrients into cells. Their study reveals that these transport proteins rely on a previously uncharacterized intermediate state, similar to the 'transition state' in enzyme catalysis.
Professor Timo Betz's project aims to develop synthetic materials that mimic key behaviors of living cells, including self-organization and physical adaptation. By studying the mechanical properties of living cells, he will recreate part of the cell's interior in a synthetic way.
Decisions on extracorporeal membrane oxygenation (ECMO) for severe respiratory failure rely heavily on clinical judgments rather than objective guidelines. Variability in decision-making may lead to inconsistent allocation of this life-supporting treatment. The study aims to improve ECMO accessibility and equity.
A new study suggests that physical properties guided life before genes did. Phospholipids with more unsaturated bonds were more likely to merge and grow under freeze-thaw cycles.
CiQUS researcher Julián Bergueiro's project ChiroPore aims to develop selective molecular transport across membranes, while Sara Abalde-Cela's OBSERVER project studies cell-cell communication as a dynamic process. Both projects have the potential to impact biomedicine, chemistry, and biotechnology
A ring-shaped 'cap' has been found to regulate the connection of gap junctions, enabling the direct exchange of information between cells. This discovery may hold implications for controlling electrical signals in the heart or intestine.
A new study from Aarhus University reveals microscopic pores in brain cells formed by toxic α-synuclein oligomers, which constantly open and close like tiny revolving doors. This dynamic behavior may help explain why brain cells don't die immediately, but further research is needed to replicate the findings in biological tissue.
A team of Chinese scientists has developed a high-performance iron-based catalyst for proton exchange membrane fuel cells (PEMFCs), which could potentially reduce reliance on scarce and expensive platinum. The new design enables record efficiency and long-term durability, achieving an oxygen reduction overpotential as low as 0.34 V.
Researchers identify packing density as key factor affecting membrane elasticity, offering new insights into homeostasis and cellular behavior. This discovery has significant implications for drug delivery applications and the development of lifelike artificial cells.
Scientists have found a way to simulate metabolic processes in the absence of cell membranes using heat flow across thin, water-filled pores. This breakthrough provides new insights into the origin of life and offers approaches to biotechnology for creating synthetic living entities.
A new study reveals how nymphaeol A, a bioactive compound in propolis, behaves within complex biological membranes. The molecule spontaneously inserts into the membrane, altering its structure and increasing fluidity, which may enhance its therapeutic effectiveness.
Researchers developed a novel amine-functionalized graphene oxide (NGO) membrane reactor for ultrafast synthesis of propranolol, achieving nearly 100% conversion and selectivity in under 4.63 seconds at 23°C. The NGO membrane exhibited higher catalytic flux and turnover frequency compared to the acidic graphene oxide (GO) membrane.
Researchers at Politecnico di Milano have developed a system that allows bacteria to sense light and convert it into electrical signals without genetic modification. This method has the potential to develop next-generation antimicrobial platforms and biocompatible 'bacterial robots' for targeted drug delivery.
Scientists have discovered a Triassic-era fossil with an elongated jaw structure, similar to modern-day pike and needlefish. The findings suggest that different species independently evolved similar jaws hundreds of millions of years apart, highlighting the universal problem-solving strategies in nature.
A team of researchers has revealed the molecular mechanisms underlying the binding of small extracellular vesicles to host cells, which could lead to the development of more effective cancer treatments. The study found that EVs primarily bind to laminin via CD151-associated integrin heterodimers and GM1, eliciting responses in recipien...
Researchers discovered that mammalian membranes have drastically different phospholipid abundances between their two leaflets, contradicting a major assumption of cell biology. The asymmetry is enabled by cholesterol's unique properties, which act as a buffer to redistribute between the leaflets and maintain robust barriers.
Researchers discovered a new process by which cancer cells use small extracellular vesicles to spread to healthy tissue. The study found that these vesicles are primarily internalized by clathrin-independent endocytosis via galectin-3, which is facilitated by an increase in intracellular calcium concentration.
The TTUHSC Graduate School of Biomedical Sciences hosted the 37th Student Research Week, showcasing student researchers' work and presentations from distinguished national speakers. The event featured an increase in abstract submissions and lightning talk sessions.
A team of researchers at UC Davis Health discovered a novel bioelectrical mechanism that allows Salmonella bacteria to navigate the gut lining and find vulnerable entry points. The study found that Salmonella bacteria detect electric signals in FAE, which helps them move towards openings in the gut where they can enter.
Researchers at UNIGE have discovered how yeast cells respond to physical stress on their membranes. Cryo-electron microscopy revealed that specific lipid domains can stabilize and trigger cellular responses to mechanical stimuli. This study sheds light on the role of membrane compartmentalization in cell survival.
Researchers used AI to investigate MOF-based membranes for helium extraction, revealing critical factors influencing separation performance. The study identified pore limiting diameter and void fraction as key physical features determining membrane selectivity and helium permeability.
Aston University has established the Aston Institute for Membrane Excellence (AIME) with a £10m grant from Research England. The institute aims to develop novel biomimetic membranes through interdisciplinary collaboration between biology, physics, and chemistry.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
Researchers have discovered a new target for antibiotics that could treat multi-drug resistant superbugs. The antibiotic AMC-109 affects the cell membrane of bacteria by disordering its organization, leading to the death of the bacterium. This approach may also break down resistance to old-fashioned antibiotics.
Researchers have uncovered a previously unknown process in marine phytoplankton that accounts for between 7% to 25% of all oxygen produced and carbon fixed in the ocean. This discovery sheds light on how tiny organisms contribute to global oxygen production, with potential implications for our understanding of evolution.
Scientists discovered that an artificial cell membrane can exhibit long-term potentiation, a hallmark of biological learning and memory, persisting for many hours. This finding has the potential to revolutionize next-generation computing materials and architectures by merging functions of processing and memory in neuromorphic computers.
A recent study by Texas Tech University Health Sciences Center researchers has shed light on the mechanisms of salt transport across membrane barriers. The findings have significant implications for treating cystic fibrosis, a disease caused by mutations in three types of sodium-potassium pumps.
Scientists have elucidated the regulatory functions of Pan1p, a key player in late-stage clathrin-mediated endocytosis. The protein drives actin assembly and disassembly, facilitating vesicle internalization.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A new method using four frequencies of applied voltage improves impedance cytometry for measuring cell size and shape, enabling faster and more accurate biological experiments. The technique reveals specific characteristics of living single cells without damaging them.
The German Research Foundation has granted funding to Johannes Gutenberg University Mainz (JGU) and its strategic alliance partners for four years. Researchers in materials sciences, biophysics, and medicine are working on three collaborative projects with a total funding volume of EUR 35 million. The focus is on developing multiscale ...
The article suggests a potential treatment option for COVID-19 by targeting SARS-CoV-2's interaction with ACE2 receptors. Combining DPP4 inhibitors and spironolactone may mitigate COVID-19 complications and infections without adverse side effects.
Researchers at the University of Illinois have developed a new type of water filtration membrane that mimics the natural process of morphogenesis. The membranes, made from soft polymers, exhibit complex 3D structures that allow them to efficiently separate pollutants from water.
A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.
Researchers discovered that yeast cells can actively regulate temperature-dependent phase separation in their membranes. This process is crucial for membrane function and cell division. By adjusting the temperature, yeast cells can maintain a consistent state of phase separation, which may be essential for optimal cellular performance.
Researchers in Japan have designed the first de novo-designed peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. The peptides can detect specific molecules, including DNA, and have the potential to mimic natural proteins' ability to detect specific proteins.
Researchers have developed Mass-Sensitive Particle Tracking (MSPT) to analyze proteins on biological membranes in real-time. The method enables the determination of protein location and size changes without labeling, providing valuable insights into dynamic processes at the membrane.
The Biophysical Society has selected 31 student researchers who presented outstanding work at the annual meeting poster competition. These students demonstrated exceptional skills in bioenergetics, bioengineering, biological fluorescence, and other areas of biophysics.
A team of biophysics developed a computer model that shows antiseptics cause changes in bacterial membrane structure, making them weaker and more susceptible to external factors. The study's results can help combat bacterial resistance by optimizing antiseptic use and developing new agents.
Enrico Gratton, a renowned researcher in lipid biophysics, will receive the 2019 Avanti Award. His pioneering work has led to significant discoveries on membrane heterogeneity and nanodomains, advancing our understanding of biological membranes.
A study published in Nature Physics reveals that small changes in physical parameters can significantly impact the formation and growth of cell-cell contacts. The researchers used computer simulations and experiments to investigate the biophysicics of cadherin proteins, which play a crucial role in maintaining cellular bonds.