Mitochondria
Articles tagged with Mitochondria
Metformin’s real power may be in the gut
NUS Medicine partners MitoQ New Zealand to deepen mitochondria-targeted research for healthy ageing
The partnership aims to generate evidence on the potential of MitoQ to slow or improve markers of biological ageing and support longevity. Mitochondria-targeted antioxidants like MitoQ are crucial in producing energy while reducing oxidative stress, a key contributor to ageing.
FAU review: Obesity and Alzheimer’s linked by disease-driving metabolic pathways
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Study points to new treatment target for fatal infant heart disease
Researchers at Keck School of Medicine have identified a new potential treatment target for AARS2-related cardiomyopathy, a rare and fatal heart muscle disease in infants. By targeting the PCBP1 gene, they aim to restore healthier AARS2 function in heart cells and prevent damage.
Measuring the ‘empty tank’: Pilot study gauges muscle energy in cancer survivors
Researchers measured mitochondrial function using MRI in 11 cancer survivors, finding slower recovery time signals weaker function, but also a surprising correlation between worse mitochondrial recovery and lower fatigue. The study suggests that subjective experience of fatigue is multidimensional and not solely physical.
Scientists reverse brain aging, with a nasal spray
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
ATF5 required for maintaining mitochondrial homeostasis and skeletal muscle health during aging
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
How does mitochondrial DNA affect your health?
Salk Institute researchers have developed a new biological platform for studying mitochondrial DNA in human physiology, adaptation, and therapeutic development. The platform allows scientists to investigate mitochondrial DNA variation in health and disease, enabling therapeutic innovation for mitochondrial disorders.
Transferring cytoplasmic contents and organelles between living cells
A Waseda University research team developed a nanotube membrane-based injector to directly and reliably manipulate the cytoplasmic composition of living cells. The system successfully transferred cytoplasmic contents, including mitochondria, into target cells with high efficiency and minimal damage.
How mitochondria organize our “second genome”
Researchers identify 'mitochondrial pearling' as key process for maintaining uniform spacing of nucleoids in mitochondria. Pearling involves a transient transformation that helps redistribute mtDNA clusters, ensuring efficient energy production and preventing disease.
Reprogramming ‘gatekeeper’ immune cell may boost cancer immunotherapy
Scientists discovered how tumors disable dendritic cell function by decreasing their mitochondrial fitness, leading to weakened immune defenses against cancer. Restoring mitochondrial function in dendritic cells improves antitumor immune responses and enhances immunotherapeutic efficacy.
Mediterranean diet may boost mitochondrial signals linked to heart and brain health
Researchers found that people following a Mediterranean-style diet have higher levels of humanin and SHMOOSE, which are linked to protection against cardiovascular disease and neurodegeneration. The study suggests that specific components of the Mediterranean diet may directly influence mitochondrial biology.
High-intensity interval training boosts muscle power plants
A new study shows that high-intensity interval training increases the number of mitochondria and expands the active membrane, enhancing energy production and potentially improving endurance. The findings, published in the University of Southern Denmark, also suggest that muscle mitochondria are more adaptable than previously thought.
CRISPR-based technique unlocks healing power of mitochondria for heart failure therapy
Researchers at Rice University developed a CRISPR-based technique that increases mitochondrial production in heart cells, improving energy levels and pumping contractions. The system successfully boosted mitochondrial function in human cell types, animal models, and adult human heart donor tissue.
Understanding how cells take up and use isolated ‘powerhouses’ to restore energy function
A recent study has shed light on the processes that drive mitochondrial uptake and its benefits for cells. Isolated mitochondria were found to be taken up by mesenchymal stromal cells, enhancing proliferation and cytoprotection, and improving energy metabolism.
Rice stink bug genetic mapping offers clues to curb a costly crop pest
Researchers have discovered that native rice stink bugs have more genetic diversity than invasive species, which could help monitor the spread of insecticide resistance. This study provides valuable insights into pest management for Arkansas rice growers, who face significant costs due to the bug's impact on their crops.
Researchers sharpen understanding of how the body responds to energy demands from exercise
A new study published in Science Advances has shed light on how the body responds to energy demands from exercise, identifying a crucial cell signaling mechanism that could lead to a new treatment for diabetes. The research focuses on Adenosine Monophosphate-Activated Protein Kinase (AMPK), a regulator of energy production, and reveals...
Study identifies aging-associated mitochondrial circular RNAs
A study profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells from young and old human cohorts, revealing that circMT-RNR2 levels are depleted in older cohorts and are involved in promoting the TCA cycle. Loss of GRSF1 reduces circMT-RNR2 levels, decreasing mitochondrial TCA intermediates and accelerating cellular ...
Emotional memory region of aged brain is sensitive to processed foods
A new study suggests that a lack of fiber in the diet may impair emotional memory in older adults, linked to cognitive problems and inflammation. The amygdala, responsible for processing fearful experiences, is sensitive to highly processed diets, regardless of fat or sugar content.
The cells that never sleep: How slumber lets neurons clean up and stay healthy
Research by Amita Sehgal and her team reveals that sleep helps neurons stay healthy by removing oxidative damage through lipid transfer to glia cells. This process is crucial for maintaining neuronal function and may contribute to the development of neurodegenerative diseases like Alzheimer's.
Parkinson’s disease triggers a hidden shift in how the body produces energy
Researchers found that Parkinson's patients experience weight loss due to selective fat depletion, not muscle loss, driven by impaired carbohydrate-based energy production. This metabolic shift highlights a disorder of both the brain and body, driving disease progression.
Targeting Longevity 2026: Scientists shift the longevity debate from “fixing aging” to preserving biological coordination
Researchers focus on system-level resilience and long-term biological coordination to understand aging as a loss of coordination between biological systems. Studies show how mitochondrial signaling influences inflammation in senescence and microbiota–brain interactions shape aging trajectories.
New dual-action compound reduces pancreatic cancer cell growth
Researchers found that an experimental compound SB-216 reduced the growth of pancreatic ductal adenocarcinoma cells by inhibiting oncogenic microtubules and mitochondrial function. This approach may reduce cancer cell adaptation and survival.
Power of tiny molecular 'flycatcher' surprises through disorder
A new study reveals that a tiny, disordered protein in mitochondrial supercomplexes can increase energy-conversion efficiency by up to 30% through its acidic and flexible region. This 'molecular flycatcher' protein hooks and shepherds electron carriers toward reaction centers, reducing the energy barrier for efficient metabolism.
Marine pollutants disrupt cellular energy production in seabirds
Research found that widespread contaminants like mercury and certain PFAS compounds affect the function of mitochondria in wild seabirds, potentially undermining fitness. The study measured pollutant levels and mitochondrial function in Scopoli's shearwaters and connected diet to exposure through stable isotopes.
Inflammation and mitochondrial dysfunction in cirrhotic cardiomyopathy: Therapeutic implications
Cirrhotic cardiomyopathy involves structural, inflammatory, and metabolic pathologies. Inflammation and mitochondrial dysfunction promote cardiac damage, and the liver-heart axis highlights the impact of cirrhosis severity on cardiac health.
Scientists boost cell "powerhouses" to burn more calories
Researchers develop experimental drugs that encourage mitochondria in cells to work harder and burn more calories. The findings offer a framework for designing safe and effective weight-loss treatments with potential benefits for metabolic health and neurodegenerative diseases.
Discovery of the most intron-rich eukaryotic genome
Researchers used long-read sequencing to analyze the nuclear genome of Amorphochlora amoebiformis, revealing an extremely high proportion of introns (74%) compared to other eukaryotic genomes. The study provides important insights into the evolutionary dynamics and potential functional roles of introns in eukaryotic genomes.
Promising target improves antitumor response in preclinical models of pancreatic cancer
Researchers at MD Anderson Cancer Center have found that inhibiting GFER, a mitochondrial enzyme, in combination with immune checkpoint blockade improves antitumor response in preclinical models. This two-pronged approach holds promise for patients with pancreatic cancer.
Mitochondria may be missing link between mental health and brain function
Research suggests that mitochondria, the powerhouses of cells, play a crucial role in linking psychological processes to physiological changes in the brain. Alterations in mitochondrial function have been linked to various mental health disorders and physical health outcomes.
Mitochondria migrate toward the cell membrane in response to high glucose levels
Research shows that high glucose levels cause mitochondria to move towards the periphery of pancreatic beta cells. This movement is linked to insulin secretion and may play a role in regulating blood sugar levels. The study found that inhibiting microtubules disrupted this process, suggesting a key role for these structures in mitochon...
MD Anderson shares latest research breakthroughs
Proton therapy has been shown to provide a significant survival benefit for patients with head and neck cancers. In another study, researchers have identified a promising target for treating pancreatic cancer by inhibiting the mitochondrial enzyme GFER. Additionally, diagnostic breast MRI may be unnecessary for some patients with early...
Structural support protein takes center stage in maintaining mitochondria
Researchers discover GFAP's crucial role in regulating mitochondrial fusion and fission, a dynamic process that meets cells' energy needs. The study sheds light on Alexander disease, a genetic disorder caused by GFAP mutations, providing potential new avenues for therapies.
Study links America’s favorite cooking oil to obesity
A study conducted at the University of California, Riverside, has uncovered a link between soybean oil consumption and obesity in mice. The research found that a genetically engineered group of mice on a high-fat diet rich in soybean oil did not gain weight, suggesting that the liver protein HNF4α plays a crucial role in fat metabolism.
Recharging the powerhouse of the cell
A team of researchers from Texas A&M University has developed a new method to give damaged cells new mitochondria, restoring energy output and cell health. The technique uses nanoflowers to boost stem cells, which then transfer their surplus mitochondria to injured neighbors.
The complex relationship between mitochondria and tumorigenesis
The review highlights the complex relationship between mitochondria and tumorigenesis, exploring molecular mechanisms underlying this association. Mitochondrial dysfunction is linked to various cancers, and targeting mitochondria represents an ideal anti-tumor therapeutic approach.
New type of DNA damage found in our cells’ powerhouses
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization, overcoming phototoxicity and halo artifacts. ExAPC microscopy captures biomolecular condensate-like structures and cellular responses to drugs.
New drug protects mitochondria and prevents kidney injury in mice
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
Mitochondria–endoplasmic reticulum cross talk in colorectal cancer (CRC)
Research highlights the importance of mitochondria-endoplasmic reticulum cross-talk in colorectal cancer, regulating Ca2+ homeostasis and lipid metabolism. Novel therapeutic strategies targeting this crosstalk may suppress CRC progression and improve patient outcomes.
From food to fuel: How leucine enhances mitochondrial energy production
A research team discovered that leucine prevents the degradation of specific mitochondrial proteins, enabling efficient energy production. This mechanism allows cells to adapt to increased energy demands during periods of nutrient abundance.
Mitochondria and lysosomes reprogram immune cells that dampen inflammation
Researchers at St. Jude Children's Research Hospital found that metabolism guides the activation states of regulatory T cells, which dampen inflammation. The study reveals a link between mitochondrial function and lysosome activity in controlling these immune cells.
Hidden toxins in e-cigarette fluids may harm lung cells
Researchers at UC Riverside discovered that two toxic chemicals can form when propylene glycol is heated, harming human lung cells. The chemicals, methylglyoxal and acetaldehyde, disrupt cell functions and cause damage even at low levels.
Study paves the way for new therapeutic strategies against obesity
Researchers at Redoxoma found that mitochondrial potassium channels regulate heat production in brown adipose tissue, a process critical for regulating energy expenditure and promoting metabolic health. Closing the channel is necessary for maximum thermogenesis.
Saving cells from the brink of death—why it matters
Researchers at UTA discovered that mitochondria can protect a cell from dying by taking in calcium, regulating complex cell death. The findings offer insights into brain development and disease, potentially leading to targeted treatments.
From powerhouse to precision target: Mitochondria is life
The congress brings together experts to explore mitochondria's role in cellular dynamics, metabolic control, and therapeutic targets. Key findings include the emergence of mitochondria as biological sensors and decision-makers, translating environmental signals into cellular fate.
Quantum-entanglement-enhanced pH probe SITE-pHorin reveals organelle pH landscape
The development of a new pH probe, SITE-pHorin, offers precise organellar pH imaging in living cells. By harnessing quantum-entanglement interactions, the probe boasts unparalleled sensitivity and resolves long-standing controversies over mitochondrial and lysosomal pH.
Who is attending? Global industrial, investors & institutional leaders unite at Targeting Mitochondria 2025 – Berlin
The 17th World Congress on Targeting Mitochondria will gather world's leading experts from biotechnology, pharma and academia to discuss health, longevity and precision medicine. Over 150 academic and institutional partners and 30 industrial and investment organizations are participating.
Alzheimer’s protein holds clues for fighting cancer
Researchers found that a protein linked to Alzheimer's disease also strengthens the immune system, offering insights into innovative treatments for cancer, aging and neurodegenerative diseases. The protein, amyloid beta, plays a dual role in the body by damaging brain cells while boosting T-cells' energy production.
Launch of www.mitogether.com, the reference website for professionals and families affected by genetic mitochondrial diseases
www.mitogether.com centralizes knowledge on genetic mitochondrial diseases affecting 1 in 4,300 people in Europe, with innovative therapies emerging. The platform facilitates information searches for monitoring, care, research, and clinical trials.
Scientists discover how nanoplastics disrupt brain energy metabolism
Researchers from Trinity College Dublin discovered that nanoplastics can interfere with brain energy production by disrupting the electron transport chain in mitochondria. This finding may have implications for understanding neurodegenerative diseases and learning/memory issues.
Deciphering mitochondria: Unveiling their roles in mechanosensing and mechanotransduction
Mitochondrial dysfunction is linked to various diseases, including neurodegenerative disorders and cancers. Mitochondria can be transferred between cells via tunneling nanotubes, restoring cellular respiratory function. Understanding mechanotransduction pathways involving mitochondria is essential for developing effective therapies.
Healthy telomeres key for cancer-fighting t cells
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
Macrophages swallow damaged mitochondria through microautophagy
Researchers from The University of Osaka discovered that macrophages can directly engulf and digest damaged mitochondria through a process called microautophagy. This process allows lysosome-like compartments in macrophages to take in broken cell components directly, bypassing the need for digestion.
World's first clinical trial showing lubiprostone aids kidney function
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
Mitochondrial antioxidant found to drive breast cancer metastasis
Researchers found that mitochondrial antioxidant glutathione enables tumors to break away from the primary tumor, travel through the body, and take root in new tissues. Elevated SLC25A39 expression was strongly correlated with poorer overall survival in breast cancer patients.
PDE4DIP dysfunction contributes to LVNC development
Recent research elucidates PDE4DIP's role in driving Left Ventricular Non-Compaction (LVNC) development through regulating cell polarity, cytoskeleton, and energy metabolism. The study identifies PDE4DIP as a pathogenic gene contributing to LVNC progression.
Nanoflowers show promise in healing brain cells and tackling neurodegenerative diseases
Researchers discover flower-shaped nanoparticles that restore mitochondrial health, offering hope for new treatments targeting the roots of neurodegenerative diseases. The study found nanoflowers can protect and heal brain cells by promoting healthy mitochondria.
Beyond classic stress signalling: how mitochondrial stress softens the cell nucleus and alters cellular identity
Researchers discovered that mitochondrial dysfunction triggers a sophisticated metabolic response in brown fat cells, rewiring key enzymes to produce D-2HG. This metabolite modifies the cell nucleus, changing gene expression and nuclear structure, promoting adaptation and altering cellular identity.