Articles tagged with Nuclear Export
Researchers discovered a point mutation in the fruit fly Drosophila melanogaster that leads to a temperature-dependent lengthening of circadian clock periods. The mutation affects the nuclear export signal of the PERIOD protein, resulting in its retention in the cell nucleus at higher temperatures.
Researchers at The Pennsylvania State University College of Medicine discovered that the nuclear export of the opioid growth factor receptor (OGFr) is CRM1 dependent. OGFr must translocate into the nucleus to facilitate its role in cell cycle regulation and does so utilizing nuclear localization signals and β and Ran proteins.
Researchers discovered that selective inhibition of nuclear export protein CRM1 can reactivate tumor suppressor proteins in cells, leading to cancer cell death. This approach shows promise for treating advanced prostate cancers.