Articles tagged with Nuclear Membranes
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Researchers have developed novel membranes that can pull lithium directly out of salt-lake brines using electricity, leaving other metal ions behind. The process could reduce the environmental impact of lithium mining and contribute to more efficient energy storage systems for renewable energy sources.
Researchers at UC San Diego developed nanopillars that breach the nucleus of a cell without damaging its outer membrane. This technology has potential applications in gene therapy and drug delivery. The researchers observed that only the nuclear membrane was punctured, leaving the rest of the cell intact.
Researchers discovered that Huntington's disease protein aggregates cause breaks in the nuclear envelope, leading to DNA damage and misregulation of neuronal genes. The study suggests a common mechanism for neurodegenerative diseases involving nuclear aggregate-induced ruptures.
Researchers developed a Pix-2-Pix GAN model to correct PSMA PET/CT images, improving image quality and quantitative markers. The AI-generated images show high correlation with original images and potential for reducing CT scans without compromising image quality.
Researchers at the University of Toronto have discovered a DNA repair mechanism that uses nuclear metamorphosis to fix double-strand breaks in human cells. This discovery has significant implications for cancer treatment and premature aging, and may lead to new therapeutic avenues.
Researchers develop molecular jackhammers that use aminocyanine molecules to create plasmons, which rupture melanoma cell membranes with high efficiency. The method showed a 99% success rate against lab cultures of human melanoma cells and cured half of the mice with melanoma tumors.
A new nano-sized force sensor developed by Tampere University researchers allows for the measurement of intracellular forces and mechanical strains. This technology has great potential for studying cancer cells and understanding cellular mechanics.
Researchers have discovered that nuclear pore IDPs form a dynamic barrier that allows essential cellular factors to pass while blocking viruses and pathogens. The team used synthetic biology, multidimensional fluorescence microscopy, and computer-based simulations to study IDPs in living cells.
A new study at Stanford University found a previously unknown cellular pathway for clearing misfolded proteins from the nucleus. This pathway could be a target for therapies of age-related diseases like Alzheimer's, Parkinson's, and Huntington's. Cells use this pathway to manage misfolded proteins in both the cytoplasm and nucleus.
Scientists have discovered that wrinkles in the cellular nucleus may be involved in common metabolic diseases such as diabetes and fatty liver disease. The new findings suggest that targeting these wrinkles could lead to novel treatments for non-alcoholic fatty liver disease, which affects 40% of people over age 70.
A new study has identified a protein called LAP1 that makes melanoma cells more aggressive by changing their nucleus shape. The protein allows cancer cells to migrate and spread throughout the body, leading to poor outcomes in patients.
A team of researchers identified the precise mechanism of nuclear envelope repair, finding that lamin C, BAF, and cGAS work together to facilitate rapid repair. The study provides insights into rare genetic disorders such as laminopathies and has potential applications for understanding and treating related diseases.
Researchers found that adult heart cells have fewer communication pathways called nuclear pores, which may protect against harmful signals but prevent regeneration. This discovery sheds light on why adult hearts do not regenerate like newborn mice and human hearts.
Researchers have discovered that palmitoylation can occur at the plasma membrane, paving the way for innovative drug discovery strategies. A novel tool, SwissKASH, allows for dynamic observation of this process, enabling precise targeting of oncogenic proteins in cancer therapy.
Researchers have confirmed that variants in the LMNB1 gene cause syndromic microcephaly by disrupting the nuclear envelope, leading to misshapen nuclei and impaired function. The study highlights a new genetic cause of congenital abnormalities and broadens the understanding of laminopathies.
A recent study published in Nature reveals that the protein Ki-67 plays a crucial role in excluding large cytoplasmic components from the nucleus before nuclear envelope reassembly. This exclusion process is essential for maintaining cellular compartmentalization and preventing premature translation of immature RNAs.
A new study identifies a specific gene's role in fertility, finding mutations in this gene are associated with early menopause. The researchers used genetic techniques to find genes involved with eye development and discovered the gene is essential for reproductive organs.
Viral particles move along microtubules to form a nuclear vesicle, releasing HIV-1 into the nucleus. This phenomenon is similar to cell endocytosis and reveals new insights into HIV-1 nuclear entry.
Eukaryotic chromosomes are separated into active euchromatin and inactive heterochromatin by interactions between the two chromatin types. The researchers discovered that heterochromatin core serves as a microlens condensing light in nocturnal retinas.
A study published in Nature Communications found that Lem2 is key to nuclear size control in the model organism Schizosaccharomyces pombe. Researchers confirmed Lem2's role by assessing changes in nuclear volume/cytoplasmic volume ratio after deleting or overexpressing the protein.
FSU researchers have uncovered a novel protein degradation pathway that may lead to better understanding of muscular dystrophy and other diseases. The study, led by FSU graduate student Bailey Koch, found that an enzyme responsible for breaking down a key protein linked to these conditions is essential to cellular processes.
Researchers visualize two distinct meshworks in the nuclear lamina, an outer layer made of lamin B1 and an inner layer of lamin A. This discovery may lead to a better understanding of genetic diseases like ADLD and how cells can compress without damaging their nuclei.
A study published in PLOS Pathogens reveals how the human myxovirus resistance 2 (MX2) protein blocks HIV-1 infection by inhibiting nuclear import of viral DNA. The findings suggest that TNPO1 and nucleoporins facilitate MX2 positioning at the nuclear envelope.
Researchers propose using viruses to restore normal functioning of cells' nuclei, potentially eradicating unwanted effects of aging. Wrinkled nuclear membranes may be responsible for metabolic diseases such as diabetes and fatty liver disease.
Researchers at Rockefeller University have mapped the architecture of the nuclear pore complex in yeast cells, revealing a massive cylindrical configuration with flexible components. The study provides insights into cell transport and may aid efforts to understand and treat diseases linked to defects in the pore complex.
Scientists have identified a previously undetected motion in the human cell nucleus, which decreases over time during the cell cycle and marks the first physical feature to systematically change with the cell cycle. This internal clock-like mechanism could contribute to understanding nuclear envelope function in health and disease.
A study by Hiroshima University researchers has discovered that controlling the hoarding of genetic materials in the nucleus causes it to bulk up. The swelling is also enabled by regulating the transport of mRNA and proteins from the nucleus into the cytoplasm, as well as lipid synthesis for nuclear membrane expansion.
A planctomycete bacterium has been found to contain internal membranes with nuclear pore-like structures, which share protein domains with eukaryotic nuclear pore complexes. This discovery may provide insight into the evolution of the cell nucleus and its membrane envelope.
A new study reveals that the nuclear membrane acts as an active regulatory structure, influencing gene expression and contributing to diseases like leukemia, heart disease, and aging disorders. The discovery provides insight into the critical role of nucleoporins in regulating genomic sites.
Scientists have discovered a new function of the nuclear membrane: repairing catastrophically broken DNA strands. The membrane fixes heterochromatin breaks, preventing chromosome aberrations and potentially fatal cancer formation. This study may reveal how organisms become more predisposed to cancer as they age.
A new quality control system has been identified in the cell's inner nuclear membrane, degrading misfolded proteins and preventing toxic accumulation. This discovery sheds light on cellular mechanisms for maintaining protein homeostasis.
Scientists at the University of Basel have discovered that proteins within nuclear pores function like a 'velcro', enabling controlled and selective transport of particles. This discovery has potential applications in lab-on-a-chip technology, where it could be used to miniaturize complex pump and valve systems.
Dr. Vivian Budnik is studying a novel mechanism of communication between the nucleus and cytoplasm, called nuclear envelope budding, which may lead to new understandings for various tissue dystrophies and aging disorders. Understanding this process could provide insights into diseases such as muscular dystrophies and Herpes virus-type ...
Researchers have discovered that nuclear envelope proteins vary greatly between cells in different organs of the body, interacting with specific proteins to cause illness in some organs but not others. This variation may provide insights into rare muscle diseases like Emery-Dreifuss muscular dystrophy and other heritable conditions.
The study reveals two independent mechanisms for fixing heterochromatin to the inner face of the nuclear envelope, using lamin A/C and the lamin-B receptor. This discovery sheds light on how the nuclear architecture in rod cells of nocturnal animals differs from normal cells.
New evidence published in Cell reveals a novel budding mechanism capable of exporting large ribonucleoprotein particles from the nucleus to the cytoplasm, fundamentally changing our understanding of mRNA export from the nucleus. This study has implications for diseases such as muscular dystrophies and herpes-type infections.
Stowers researchers used baker's yeast to study chromosome separation and found that Mps3 ensures accurate spindle pole body duplication, which is crucial for cell division. They also discovered a novel mutant with defects in nuclear membrane structure and function.
A new study identifies a mutation underlying accelerated-aging disease, providing key insights into normal human aging. The research highlights the importance of the nuclear envelope in the aging process.
Researchers identified two distinct mechanisms for nuclear pore complex assembly during interphase and post-mitotic stages, shedding light on cell cycle-dependent differences in nuclear membrane topology. The findings have implications for conditions such as cancer, developmental defects, and sudden cardiac arrest.
Researchers at UC Berkeley discover that the cytoskeleton plays a critical role in pairing and recombining chromosomes during meiosis. By forming bridges between chromosomes and patches on the nuclear membrane, the cytoskeleton helps ensure homologous chromosome pairing, a crucial step in sex cells' development.
Perturbation of lamin B1-Oct-1 interactions can affect the expression of genes regulated by Oct-1, leading to increased reactive oxygen species production. This could be a key mechanism underlying the aging process.
Scientists from University of Chicago Medical Center report that moving active genes to nucleus periphery can silence them, preventing transcription. This novel form of gene regulation involves attachment to inner nuclear membrane, blocking transcription through proteins residing on the membrane.
A team of NYU biologists has identified a gene, mel-28, that plays a crucial role in coordinating two cellular processes: chromosome segregation and nuclear envelope function. The study, published in Current Biology, used functional genomic tools to reveal the dual role of mel-28 in these processes.
Researchers at IRB Barcelona have identified a crucial protein in building the nuclear envelope, a complex structure surrounding the nucleus. The discovery of MEL-28 sheds light on how this envelope is assembled and regulated.
The Salk Institute researchers created a cell-free system to study the insertion of nuclear pore complexes into the nuclear membrane. Using advanced imaging tools, they observed the formation of nuclear membranes and pores within an hour.
A study published in Proceedings of the National Academy of Sciences found that anticancer drugs can reverse the nuclear structure abnormalities caused by a rare genetic disorder, progeria. The researchers successfully treated cells with progerin, a mutated protein linked to accelerated aging, using farnesylation inhibitors.
Researchers identify torsinA, a protein defective in DYT1 dystonia, and discover its role in the nuclear envelope. The study provides new insights into potential treatments for movement disorders and secondary dystonias.
A study at TSRI identifies 62 new proteins in the inner nuclear membrane linked to 14 rare diseases, including muscular dystrophy and Charcot-Marie-Tooth disease. This discovery has significant implications for understanding the underlying causes of these devastating conditions and developing new therapeutic strategies.
Researchers are developing cost-effective methods to capture and store carbon dioxide, with potential to reduce global warming impact. The DOE-funded projects include membrane development, vortex tube separation, and algae-based carbon sequestration.
INEEL researchers develop polyphosphazene membranes for efficient chemical separation and waste minimization, offering stability up to 300 degrees Celsius. The hybrid membrane combines organic and inorganic molecules for improved durability and versatility.