Articles tagged with Platelet Derived Growth Factor
Researchers found that regorafenib, a dual PDGFR α/β inhibitor, modifies the cancer microenvironment and enhances the efficacy of anti-PD-1 immunotherapy in advanced gastric cancers. This combination therapy boosts tumor infiltrating immune cells and reduces tumor fibroblasts.
Researchers discovered PDGF cross-signaling through alternative receptors in colorectal cancer cells, enabling bypassed signaling. This finding supports anti-PDGF therapy as a combination strategy alongside VEGF and EGF targeting.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A novel adhesive patch platform has been developed by a research team at Pohang University of Science & Technology (POSTECH) to efficiently deliver blood vessel-forming growth factors using mussel adhesive protein. The platform demonstrated effective neovascularization in rat models for myocardial infarction and excisional wounds.
Scientists have created a new 3D cell culture model of the pulmonary arterial wall to study pulmonary arterial hypertension. The model successfully recapitulates the process central to the pathogenesis and progression of PAH, allowing researchers to test potential drug candidates for treatment.
Researchers pinpoint cell that triggers scarring in fatty tissue, leading to insulin resistance and diabetes. The study reveals a potential new target for treating metabolic disorders.
A recent clinical study has shown that applying a growth factor to the brain may help preserve dopaminergic cells and fibers, increasing dopamine signaling in patients. The study suggests that future therapies could utilize the brain's own protective mechanisms to limit neuronal cell death and restore natural dopamine production.
Researchers create implantable tissue scaffold coated with bone growth factors that induce rapid formation of new bone. The scaffold induces the body to rapidly form new bone that looks and behaves like original tissue.
A novel cocktail of neutralizing reagents has been developed to treat proliferative vitreoretinopathy (PVR), a sight-threatening complication after retinal detachment surgery. The approach targets growth factors and cytokines that promote PVR, with promising results in animal models.
Researchers at Stanford University School of Medicine have identified a key molecular pathway responsible for the decrease in insulin-producing cells with age. Activating this pathway may lead to a new treatment for diabetes, and recent studies have shown promising results in mice.
Scientists at Stanford University have identified a molecular pathway responsible for the decline of beta cell division with age. By manipulating this pathway, they can restore the ability of older beta cells to divide and generate new cells, potentially leading to breakthroughs in treating both type 1 and type 2 diabetes.
Researchers at the University of Michigan have discovered a method for controlling the growth rate of replacement tissue and forming new blood vessels. This breakthrough could be used in various medical procedures, such as bone grafts and dental treatments, to help patients with wound healing problems.
Researchers investigated how cell signaling in the stroma of cervical cancer affects tumor growth, revealing a key role for platelet-derived growth factor (PDGF). A genetic variant impairing glycogen synthesis was also identified in human skeletal muscles and linked to decreased muscle glycogen content.
Researchers found that a combined treatment with rapamycin and Gleevec significantly reduced splanchnic neovascularization and portal pressure in rats with established portal hypertension. The combination treatment was more effective than using either drug alone, suggesting a potential new approach for treating human patients.
Abnormal stimulation of a cellular trigger causes invasive tumor-like growths in mice, which regress upon removal. The study suggests a possible treatment for lethal brain tumors by targeting PDGFRá B cells.
Researchers have uncovered a complex network of how one bad guy regulates another bad guy, finding a key peptide hormone called angiotensin controls the expression of an important part of PDGF. This discovery could lead to specific inhibitors of growth factor production to reduce the incidence of common vascular disorders.
Researchers introduce molecularly engineered DNA strands into cell cultures to detect biomarkers in complex samples. The technique could help identify cancers at earlier stages and monitor residual cancer after treatment.
A new study published in The Journal of Clinical Investigation found that decreased function of the CREB gene transcription factor is involved in anxiety and excessive alcohol drinking behavior. Decreased CREB function was shown to be important for maintaining high anxiety and excessive alcohol drinking. This genetic determinant create...
Researchers at the University of Michigan successfully grew new, mature blood vessels in live animals by implanting scaffolds that delivered critical growth factors. The innovative approach, reported in Nature Biotechnology, has potential medical applications for alternatives to heart bypass surgery and treatments for vascular disease.
Researchers at the University of Michigan have developed a new tissue engineering method that uses a polymer to encourage the formation of healthy blood vessels in living rats. The approach, which combines VEGF and PDGF growth factors, shows promise for treating coronary artery disease and speeding up wound healing.
Researchers used genetic tools to create mouse models of gliomas, revealing that the timing of PDGF expression can determine glioma characteristics. These findings suggest that drugs promoting glial cell differentiation may be effective for low-grade gliomas.