Articles tagged with Synaptic Vesicles
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Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.
Researchers at OIST discover a common molecular cascade disrupting brain signaling in both Alzheimer's and Parkinson's diseases. They identify a shared mechanism affecting synaptic vesicle recycling, leading to impaired communication between brain cells.
Max Delbrück Center researchers have uncovered new features of the molecular architecture of synaptic vesicles using cryo-electron tomography. The study reveals a persistent association between V-ATPase and synaptophysin, suggesting an important function in neurotransmission.
Researchers at OIST have discovered a novel treatment that effectively reverses the symptoms of Alzheimer's disease in mice. The treatment, PHDP5, targets the dynamin-microtubule interaction and restores communication between neurons inside synapses.
Researchers used advanced imaging technology to reveal the atomic structure of an enzyme that neurons use to communicate. The study provides new insights into synaptic function and may lead to therapeutic targets for epilepsy and other neurological conditions.
A team of scientists has shed light on how synapses are formed by identifying a shared transport pathway involving motor proteins and unique organelles. This discovery could lead to new therapeutic approaches for neurological disorders and improve understanding of neuronal regeneration.
Researchers found that packaging neurotransmitters into synaptic vesicles is a major source of energy consumption, even when the vesicles are filled and inactive. The process, known as proton efflux, continues to consume energy due to a 'leaky' energy threshold set by evolution.
Scientists have identified a dual-control system that regulates the release and recycling of synaptic vesicles, enabling precise signal transmission. Calcium channels Ca2 and Ca1 are spatially segregated, with Ca2 required for exocytosis and Ca1 enhancing endocytosis, demonstrating separate control of these processes.
Researchers at Martin-Luther-University Halle-Wittenberg studied protein interactions in synaptic vesicles, uncovering how they mesh like cogs in a clockwork mechanism. This understanding helps recognize and understand malfunctions that could trigger diseases such as Alzheimer's.
Glutamate molecules have unexpected qualities, researchers show with a new analysis method. The technique measures activity and quantity of glutamate in brain cells, shedding light on its role in neurological disorders and diseases. This breakthrough could help improve understanding of pathologies and deliver real benefit.
Researchers discovered that vesicle and scaffold proteins arrive at nascent synapses as preformed functional units, enabling instantaneous neurotransmitter release. The findings may aid in designing better nerve-regenerating therapies and accelerating synapse formation after injuries.
Researchers have discovered that protein droplets, which self-organize into liquid-like structures inside cells, enable neurons to transmit signals quickly and efficiently. In the immune system, droplets of a danger-sensing enzyme trigger an immune response by generating signals that launch defense mechanisms.
An interdisciplinary team of scientists discovered that ATM and ATR regulate each other's levels in the brain to maintain a balance between excitation and inhibition. Regular brain activity also changes the levels of these proteins, creating a dynamic 'conversation' that helps keep the appropriate E/I balance.
Researchers discovered mutations in TMEM230, a new gene linked to Parkinson's disease, in patients from North America and Asia. The gene produces a protein involved in dopamine packaging in neurons, which is crucial for movement disorder diagnosis.
Shigeki Watanabe has developed a novel ultrafast technique called 'flash-and-freeze' to visualize nerve cell activity on a rapid time scale. The technique reveals that vesicle recycling in neurons occurs through two mechanisms, an ultrafast one and a slower clathrin-dependent process.
Two studies reveal individual neurons control synaptic vesicle recycling speed, with variations across different neurons. This finding refines neuroscience's understanding of neurotransmission at the synaptic gap between brain cells.
Researchers have discovered a new protein that links nerve cell motors to their cargo, providing insights into neurotransmitter transport. This discovery could lead to new drug therapies for illnesses like Parkinson's disease and depression.
The discovery of the Skywalker enzyme reveals a crucial step in vesicle recycling, leading to improved signal transmission and potentially new diagnostics and therapies for Parkinson's disease. Understanding this process may help maintain optimal communication balance between brain cells.
Researchers at Max Planck Institute develop new method to measure synaptic vesicle priming, revealing SNAPs play crucial role in recycling SNARE complexes. Disruption of this process can lead to communication breakdown and vital processes like sight or sound detection being impaired.
Researchers at McGill University discover a molecular link between Parkinson's disease and impaired nerve cell communication. They found that parkin protein binds to endophilin-A, affecting synaptic transmission and potentially leading to dopamine neuron death.
The newly discovered tomosyn protein appears to play a key role in regulating synaptic release of neurotransmitters, suggesting its involvement in learning and memory. Mutant worms lacking tomosyn exhibit excessive neurotransmitter release, highlighting the protein's negative regulatory effect on synapse efficiency.
A research team led by Edwin R. Chapman identified the cellular receptor for botulinum neurotoxin A as SV2, a protein on actively recycling synaptic vesicles. This finding offers new insights into how the toxin shuts down nerve cells with deadly efficiency.
New research by UT Southwestern scientists reveals complexity in organization of synaptic vesicles within individual synapses, challenging long-held assumptions about neurotransmitter release. Two distinct types of synaptic vesicles are found to be responsible for spontaneous and activity-dependent release, which may aid in understandi...
A study by Yale University researchers reveals that lowering a specific lipid in nerve terminals affects neurotransmitter exchange between neurons. The findings have implications for understanding synaptic transmission and potentially developing new treatments for diseases like Down syndrome, cancer, and diabetes.
Scientists discover Munc13-1 regulates the readily releasable pool of synaptic vesicles, leading to a functional shutdown of synapses. Without Munc13-1, nerve cells cannot signal due to an arrest in vesicle maturation, highlighting its essential role in neurotransmitter release.