Articles tagged with Angiogenesis
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Glycosylated RNAs on the cell surface form clusters with RNA binding proteins, regulating interactions with surrounding growth factors and controlling angiogenesis. The study found that altering the amount of RNA on the cell surface can modify intracellular signaling cascades through selective interaction with growth factors.
Researchers discovered subtypes of chondrocytes that transform into bone-building cells, regulating bone growth and vascularization. The study found that these cells secrete Thbs4 to induce blood vessel formation, shedding insights for treating defective angiogenesis.
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
A new bioactive wound dressing combining miR-221-3p and GelMA hydrogel promotes blood vessel formation, accelerating diabetic wound healing. The study shows a 90% wound closure rate within 12 days in animal trials.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
A recent study published in The American Journal of Pathology has discovered that ADAM10 regulates abnormal blood vessel growth in the retina, which can cause vision loss or impairment. The findings suggest that targeting ADAM10 or its downstream effectors, such as Ephrin B2, may offer novel strategies for managing or preventing retina...
Researchers developed novel 3D printed PLA-CaP scaffolds that support angiogenesis, reducing bone scarring and improving healing outcomes. In vitro tests showed stimulated vascular endothelial growth factor secretion and maintained calcium ion release, while in vivo testing demonstrated good integration and blood vessel infiltration.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers have developed a cell culture platform to form two distinct, interconnected vascular networks, replicating human physiology and reducing animal testing costs. This breakthrough enables the study of cellular interactions in vascularized tissues.
Researchers found that regorafenib synergizes with TAS102 to inhibit cancer growth, angiogenesis, and microvessel density in preclinical models of colorectal and gastric cancers. The combination also suppresses ERK1/2 activation regardless of KRAS or BRAF mutational status.
This study explored the preventative role of baicalein in hepatopulmonary syndrome development. Baicalein improved survival rates, reduced angiogenic protein levels, and enhanced glucose homeostasis in HPS rats. It also attenuated pathological angiogenesis in the liver and lungs.
Researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences successfully unlocked a puzzle in vascular tissue engineering, providing important experimental evidence towards understanding and controlling sprouting angiogenesis in vitro. They developed new image-analysis protocols to determine key parameters gove...
A team of researchers from Kyoto University has developed a microfluidic co-culture vasculature chip that mimics the microenvironment of alveolar soft part sarcoma (ASPS), a rare cancer. The chip enables scientists to study cell-to-cell interactions and angiogenic mechanisms, which may lead to new strategies for treating ASPS patients.
Research by Johns Hopkins Medicine suggests that increased stiffness in aging skin contributes to higher rates of melanoma metastasis by stimulating blood vessel growth and making them leaky. Treating older mice with drugs blocking ICAM1 prevented these changes, shrinking tumors and reducing metastasis.
Researchers found that antioxidants activate a mechanism forming new blood vessels in tumor cells, which can help them grow and spread. The study suggests that dietary supplements containing antioxidants may accelerate tumour growth and metastasis in cancer patients.
Researchers discovered that vascular toxicity linked to these drugs is unrelated to angiogenesis-related genes, but rather due to changes in vascular architecture. This new understanding will help select the most effective and safe way to modulate angiogenesis in ischemic tissues or cancer.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Researchers investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. Everolimus treatment significantly inhibited cell growth and reduced tumor angiogenesis and lymphangiogenesis.
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
YAP1 controls angiogenesis by expressing genes involved in blood vessel formation, and its activity is regulated by PHD2 and VHL under normal oxygen conditions. In hypoxic conditions, YAP1's nuclear localization enables it to interact with HIF1α, leading to increased expression of pro-angiogenic proteins.
Researchers have discovered a new molecular treatment effective against low-flow vascular malformations using the AKT inhibitor miransertib. The study also found that active angiogenesis is needed for malformations to occur, opening the door to preventive strategies.
Researchers at Institute for Basic Science discovered Merlin's crucial role in regulating angiogenesis. By suppressing VEGFR2 internalization, Merlin prevents tip EC induction and promotes balanced sprouting angiogenesis. This study sheds light on the importance of Merlin in maintaining capillary integrity and proper angiogenesis.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
Scientists found that a single 45-minute session of moderate-intensity exercise enables the growth of new blood vessels in people with type 2 diabetes. The exercise increases levels of ATP7A, a protein carried by exosomes that helps deliver essential copper to endothelial cells, promoting angiogenesis and reducing oxidative stress.
Researchers at UC Irvine and IIT develop ALY101, a compound that blocks protein-protein interactions crucial for cancer and rare disease progression. The findings validate a new approach to structure-based drug design, with potential applications in monotherapy or combination regimens.
Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Researchers found a unique bivalent histone-mark switch specific to critical transcription factors that induce genes essential for angiogenesis. The histone modifiers responsible for this modification are vital for postnatal angiogenesis.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Metastases in malignant melanoma can use an alternative process to access the circulatory system, where a blood vessel divides into two parallel vessels. This finding challenges traditional research on tumor growth and may lead to new treatment options for metastatic cancer.
A new treatment approach targets angiogenesis, inflammation, and oxidative stress in glioblastoma multiforme, reducing tumor volume and growth by up to 89%. The combination of LAU-0901, Elovanoids, and Avastin shows promise in improving survival rates for patients with this deadly cancer.
Researchers at UArizona Health Sciences have discovered a mechanism that tumors use to keep blood vessels growing, driving cancer growth and invasion. Targeting this mechanism with drugs could lead to more effective cancer treatments by overcoming drug resistance.
Researchers at Medical College of Georgia discover that copper transporter ATP7A plays a crucial role in new blood vessel formation and restoring blood flow in ischemic cardiovascular disease. The study suggests that increasing and stabilizing ATP7A levels could lead to the development of new treatments for heart attack, peripheral art...
Alzheimer's disease disorganises blood vessels around amyloid plaques, causing loss of vessels and worsening pathology. This mechanism aggravates the disease by reducing the brain's ability to clean toxic substances, leading to increased strain on oxygen and nutrient supply.
The study identifies novel non-coding RNAs involved in regulating vascular endothelial growth factors (VEGF) expression, which are key regulators of angiogenesis. These findings may lead to new therapeutic approaches for diseases such as atherosclerosis and ischemia.
The study reveals the involvement of SARAF and Orai1 proteins in VEGF-mediated activation of endothelial cells, affecting blood vessel development. This discovery could lead to therapeutic strategies controlling angiogenesis in pathological conditions.
Researchers at Tokyo Medical and Dental University discovered a novel role for vasohibin-1 in preventing cancer cells from spreading. The protein inhibits the formation of new blood vessels by interfering with microtubule function, ultimately blocking signals that promote angiogenesis.
Younger patients with resected melanoma showed a benefit from adjuvant bevacizumab treatment, while older patients did not. The study suggests that sFRP2 may promote angiogenesis in older patients with melanoma, which is superseding the role of VEGF.
miR-151a regulates endothelial cell motility and angiogenesis, with Slug expression required for these functions, providing new insights into the processes in the lung niche environment. The study highlights the potential of miR-151a as a therapeutic target against lung cancer.
Researchers found that AEZS-108 upregulates the tumor suppressor gene MASPIN, inhibiting cell proliferation and inducing apoptosis in LHRH receptor-positive uveal melanoma cells. The study suggests that targeted cytotoxic LHRH analogs like AEZS-108 could serve as an effective treatment for patients with this disease.
Researchers have identified a genetic signature associated with the degree of pathological angiogenesis in breast cancer tumors. The study combined gene expression profiles from public databases with analysis of retinopathy models to uncover key genes involved in pathological angiogenesis, providing a new tool for breast cancer treatment.
A study by IRB Barcelona demonstrates that p38 inhibition boosts blood vessel formation in human and mice colon cancers, critical for cancer growth. The research reveals the role of p38 in mesenchymal stem cells and its involvement in angiogenesis.
Researchers at CNIC have identified a cellular and molecular mechanism that can induce productive angiogenesis in ischemic tissues. The newly discovered mechanism suggests that manipulating it could lead to optimal therapeutic angiogenesis, which may help treat cardiovascular disease.
Researchers created a lab model of a blood vessel to study angiogenesis, revealing how the molecule EGFL7 influences blood vessel sprouting and integrity. The study suggests EGFL7 as a potential therapeutic target for diseases like retinopathy and cancer.
Scientists have discovered a new relationship between the enzyme PDIA1 and Drp1 that drives endothelial cell damage in diabetes. Restoring a healthy balance of PDIA1 and Drp1 may provide new treatment targets for diseases associated with endothelial cell senescence.
A study from Harvard T.H. Chan School of Public Health found that restricting the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, suggesting improved vascular function may contribute to benefits of dietary restriction.
Researchers at the University of Tokyo developed a blood vessel-on-a-chip technology that recreates a human blood vessel and shows how new capillaries grow from a single vessel. The technology can be used to develop drugs targeting angiogenesis, which is a key process in cancer growth.
Researchers at IBS and KAIST found that YAP/TAZ promotes cytoskeleton remodeling and junction formation in endothelial cells, essential for normal as well as pathological angiogenesis. Overexpression of YAP/TAZ leads to excessive blood vessel growth, while removal results in vision impairment and internal bleeding.
Researchers from Mass Eye and Ear successfully prevented mice from developing retinal angiogenesis using CRISPR-Cas9 gene-editing techniques. The technique targets VEGFR2, a critical protein responsible for angiogenesis, and showed promising results in preclinical models.
Researchers have found that the Tie2 receptor on pericytes plays a crucial role in regulating blood vessel growth and maturation. By breeding mice with disabled Tie2 receptors, scientists discovered that tumor blood vessels grew faster and more aggressively without this control, highlighting potential new targets for cancer therapy.
Scientists at Joslin Diabetes Center have identified a new molecular pathway that may offer targets for drugs to strengthen angiogenesis and improve blood vessel growth in type 2 diabetes. The study found that CITED2 expression is increased in endothelial cells from patients with diabetes, suggesting its potential as a therapeutic target.
Researchers have found that AGGF1 promotes therapeutic angiogenesis through autophagy, increasing the number of mice that survive after acute heart attacks. Treatment with AGGF1 also improves cardiac functions and reduces scarring in the heart.
A new gene called Wars2 has been identified as a key player in blood vessel formation, providing a potential target for new therapies against cancer and heart disease. The discovery was made by researchers at Duke-NUS Medical School who found that inhibiting Wars2 function impaired blood vessel formation in rats and zebrafish.
Research suggests that haemodynamic forces play a critical role in shaping endothelial cells during angiogenesis, leading to the expansion and maintenance of vascular lumens. The study's findings challenge previous ideas about blood flow's impact on vascular development.
Researchers discovered how small capillaries form during angiogenesis, a process crucial for embryonic development, cancer, and diabetes. Blood pressure drives the membrane of endothelial cells to cave in and grow into the cell's body.
Wayne State University has secured a $1.9 million NIH grant to study the role of chemokine receptor CXCR2 in regulating new blood vessel formation and enhancing endothelial progenitor cells (EPCs)-based cell therapy for vascular diseases.