Angiogenesis
Articles tagged with Angiogenesis
Lab-grown human skin advances our understanding of the critical role of skin blood vessels in inflammation, repair, regeneration, and aging
Researchers have created lab-grown human skin organoids that can form complex microvascular networks similar to those in native human skin. These self-organizing structures function similarly to native skin, responding to inflammatory stimuli and re-growing after injury.
Researchers identify new drug target to prevent development of dangerous blood vessel defects in brain
Researchers have identified TIE2 as a crucial link between two signaling pathways that drive the growth of blood vessel abnormalities in the brain. Inhibiting TIE2 with a small drug called rebastinib may provide an endothelial cell-centered approach to prevent CCMs, which can cause brain hemorrhages and seizures.
UC Riverside professor receives Lifetime Achievement Award from Wound Healing Society
Manuela Martins-Green, a renowned researcher at UC Riverside, has been selected as the 2026 recipient of The Lifetime Achievement Award from the Wound Healing Society. Her pioneering work on chemokines and wound healing has led to critical mechanistic insights and therapies advancing toward clinical application.
Finding a function for glycosylated, cell surface RNA
Glycosylated RNAs on the cell surface form clusters with RNA binding proteins, regulating interactions with surrounding growth factors and controlling angiogenesis. The study found that altering the amount of RNA on the cell surface can modify intracellular signaling cascades through selective interaction with growth factors.
Cartilaginous cells regulate growth and blood vessel formation in bones
Researchers discovered subtypes of chondrocytes that transform into bone-building cells, regulating bone growth and vascularization. The study found that these cells secrete Thbs4 to induce blood vessel formation, shedding insights for treating defective angiogenesis.
Chinese Medical Journal study highlights exercise-induced vascular growth as anti-aging strategy
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
New bioactive dressing promises faster diabetic wound healing
A new bioactive wound dressing combining miR-221-3p and GelMA hydrogel promotes blood vessel formation, accelerating diabetic wound healing. The study shows a 90% wound closure rate within 12 days in animal trials.
Osteogenesis – Angiogenesis coupling via interlineage paracrine signaling
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Novel study uncovers the critical role of ADAM10 protein in the development of retinal disorders
A recent study published in The American Journal of Pathology has discovered that ADAM10 regulates abnormal blood vessel growth in the retina, which can cause vision loss or impairment. The findings suggest that targeting ADAM10 or its downstream effectors, such as Ephrin B2, may offer novel strategies for managing or preventing retina...
Innovative 3D printed scaffolds offer new hope for bone healing
Researchers developed novel 3D printed PLA-CaP scaffolds that support angiogenesis, reducing bone scarring and improving healing outcomes. In vitro tests showed stimulated vascular endothelial growth factor secretion and maintained calcium ion release, while in vivo testing demonstrated good integration and blood vessel infiltration.
Effects of megakaryocyte conditioned media on endothelial cell angiogenesis
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers succeed in creating two interconnected vascular networks
Researchers have developed a cell culture platform to form two distinct, interconnected vascular networks, replicating human physiology and reducing animal testing costs. This breakthrough enables the study of cellular interactions in vascularized tissues.
Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers
Researchers found that regorafenib synergizes with TAS102 to inhibit cancer growth, angiogenesis, and microvessel density in preclinical models of colorectal and gastric cancers. The combination also suppresses ERK1/2 activation regardless of KRAS or BRAF mutational status.
The therapeutic effects of baicalein on the hepatopulmonary syndrome in the rat model of chronic common bile duct ligation
This study explored the preventative role of baicalein in hepatopulmonary syndrome development. Baicalein improved survival rates, reduced angiogenic protein levels, and enhanced glucose homeostasis in HPS rats. It also attenuated pathological angiogenesis in the liver and lungs.
Bloody net
Researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences successfully unlocked a puzzle in vascular tissue engineering, providing important experimental evidence towards understanding and controlling sprouting angiogenesis in vitro. They developed new image-analysis protocols to determine key parameters gove...
If you can't beat them, mock them
A team of researchers from Kyoto University has developed a microfluidic co-culture vasculature chip that mimics the microenvironment of alveolar soft part sarcoma (ASPS), a rare cancer. The chip enables scientists to study cell-to-cell interactions and angiogenic mechanisms, which may lead to new strategies for treating ASPS patients.
Age-related changes in skin may contribute to melanoma metastases
Research by Johns Hopkins Medicine suggests that increased stiffness in aging skin contributes to higher rates of melanoma metastasis by stimulating blood vessel growth and making them leaky. Treating older mice with drugs blocking ICAM1 prevented these changes, shrinking tumors and reducing metastasis.
Antioxidants stimulate blood flow in tumors
Researchers found that antioxidants activate a mechanism forming new blood vessels in tumor cells, which can help them grow and spread. The study suggests that dietary supplements containing antioxidants may accelerate tumour growth and metastasis in cancer patients.
Scientists identify how some angiogenic drugs used to treat cancer and heart disease cause vascular disease
Researchers discovered that vascular toxicity linked to these drugs is unrelated to angiogenesis-related genes, but rather due to changes in vascular architecture. This new understanding will help select the most effective and safe way to modulate angiogenesis in ischemic tissues or cancer.
Cancer-associated fibroblasts: Challenges and opportunities
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Oncotarget | Everolimus inhibits angiogenesis and lymphangiogenesis in TP53 mutant HNSCC by downregulating STAT3/HIF-1α/VEGF pathway
Researchers investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. Everolimus treatment significantly inhibited cell growth and reduced tumor angiogenesis and lymphangiogenesis.
A double bind for cancer
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
It’s all about quality: effect of dietary fat composition on liver angiogenesis and lymphangiogenesis
Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
Chinese Medical Journal editorial probes into the role of blood vessels in treating obesity-related disorders
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
Moffitt researchers identify pathway that regulates angiogenesis in tumors
YAP1 controls angiogenesis by expressing genes involved in blood vessel formation, and its activity is regulated by PHD2 and VHL under normal oxygen conditions. In hypoxic conditions, YAP1's nuclear localization enables it to interact with HIF1α, leading to increased expression of pro-angiogenic proteins.
A new fast and reliable experimental model for vascular malformations leads to the identification of miransertib as a promising therapy option
Researchers have discovered a new molecular treatment effective against low-flow vascular malformations using the AKT inhibitor miransertib. The study also found that active angiogenesis is needed for malformations to occur, opening the door to preventive strategies.
“Merlin” serves as a gatekeeper in new blood vessel formation
Researchers at Institute for Basic Science discovered Merlin's crucial role in regulating angiogenesis. By suppressing VEGFR2 internalization, Merlin prevents tip EC induction and promotes balanced sprouting angiogenesis. This study sheds light on the importance of Merlin in maintaining capillary integrity and proper angiogenesis.
Fishing for new source of proteoglycans, an important health food ingredient
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
New evidence of how exercise can counter diabetes damage
Scientists found that a single 45-minute session of moderate-intensity exercise enables the growth of new blood vessels in people with type 2 diabetes. The exercise increases levels of ATP7A, a protein carried by exosomes that helps deliver essential copper to endothelial cells, promoting angiogenesis and reducing oxidative stress.
New molecule holds promise in potential therapies for cancer and rare diseases
Researchers at UC Irvine and IIT develop ALY101, a compound that blocks protein-protein interactions crucial for cancer and rare disease progression. The findings validate a new approach to structure-based drug design, with potential applications in monotherapy or combination regimens.
Turmeric compound helps grow engineered blood vessels and tissues
Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
Powerhouse-pruning protein may also aid new blood vessel growth in vascular disease
A study suggests that the powerhouse-pruning protein Drp1 plays a crucial role in generating energy for new blood vessel growth, particularly under low oxygen conditions. When oxygen levels are low, Drp1 gets modified to produce reactive oxygen species (ROS), which enables glycolysis and subsequent cell signaling.
Unusual partners aid blood vessel growth
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Identification of a unique "switch" for blood vessel generation
Researchers found a unique bivalent histone-mark switch specific to critical transcription factors that induce genes essential for angiogenesis. The histone modifiers responsible for this modification are vital for postnatal angiogenesis.
Novel drug liberates tumour vessels to aid cancer drug delivery
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Metastases use divided blood vessels to grow
Metastases in malignant melanoma can use an alternative process to access the circulatory system, where a blood vessel divides into two parallel vessels. This finding challenges traditional research on tumor growth and may lead to new treatment options for metastatic cancer.
New Rx combination inhibited glioblastoma multiforme tumor growth
A new treatment approach targets angiogenesis, inflammation, and oxidative stress in glioblastoma multiforme, reducing tumor volume and growth by up to 89%. The combination of LAU-0901, Elovanoids, and Avastin shows promise in improving survival rates for patients with this deadly cancer.
UArizona Health Sciences researchers identify mechanism for slowing cancer growth
Researchers at UArizona Health Sciences have discovered a mechanism that tumors use to keep blood vessels growing, driving cancer growth and invasion. Targeting this mechanism with drugs could lead to more effective cancer treatments by overcoming drug resistance.
Copper transporter potential new treatment target for cardiovascular disease
Researchers at Medical College of Georgia discover that copper transporter ATP7A plays a crucial role in new blood vessel formation and restoring blood flow in ischemic cardiovascular disease. The study suggests that increasing and stabilizing ATP7A levels could lead to the development of new treatments for heart attack, peripheral art...
A mechanism that reduces blood vessels in Alzheimer's patients
Alzheimer's disease disorganises blood vessels around amyloid plaques, causing loss of vessels and worsening pathology. This mechanism aggravates the disease by reducing the brain's ability to clean toxic substances, leading to increased strain on oxygen and nutrient supply.
Researchers discover novel non-coding RNAs regulating blood vessel formation
The study identifies novel non-coding RNAs involved in regulating vascular endothelial growth factors (VEGF) expression, which are key regulators of angiogenesis. These findings may lead to new therapeutic approaches for diseases such as atherosclerosis and ischemia.
Study identifies new targets in the angiogenesis process
The study reveals the involvement of SARAF and Orai1 proteins in VEGF-mediated activation of endothelial cells, affecting blood vessel development. This discovery could lead to therapeutic strategies controlling angiogenesis in pathological conditions.
Hinder handing the message -- stopping tumors from creating new blood vessels
Researchers at Tokyo Medical and Dental University discovered a novel role for vasohibin-1 in preventing cancer cells from spreading. The protein inhibits the formation of new blood vessels by interfering with microtubule function, ultimately blocking signals that promote angiogenesis.
Response to adjuvant bevacizumab among patients with resected melanoma may vary by age
Younger patients with resected melanoma showed a benefit from adjuvant bevacizumab treatment, while older patients did not. The study suggests that sFRP2 may promote angiogenesis in older patients with melanoma, which is superseding the role of VEGF.
Oncotarget: miR-151a enhances Slug dependent angiogenesis
miR-151a regulates endothelial cell motility and angiogenesis, with Slug expression required for these functions, providing new insights into the processes in the lung niche environment. The study highlights the potential of miR-151a as a therapeutic target against lung cancer.
The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development
Researchers found that AEZS-108 upregulates the tumor suppressor gene MASPIN, inhibiting cell proliferation and inducing apoptosis in LHRH receptor-positive uveal melanoma cells. The study suggests that targeted cytotoxic LHRH analogs like AEZS-108 could serve as an effective treatment for patients with this disease.
Novel genetic signature that can predict some kinds of breast cancer is identified
Researchers have identified a genetic signature associated with the degree of pathological angiogenesis in breast cancer tumors. The study combined gene expression profiles from public databases with analysis of retinopathy models to uncover key genes involved in pathological angiogenesis, providing a new tool for breast cancer treatment.
A study demonstrates that p38 protein regulates the formation of new blood vessels
A study by IRB Barcelona demonstrates that p38 inhibition boosts blood vessel formation in human and mice colon cancers, critical for cancer growth. The research reveals the role of p38 in mesenchymal stem cells and its involvement in angiogenesis.
A newly identified mechanism can be targeted to boost angiogenesis
Researchers at CNIC have identified a cellular and molecular mechanism that can induce productive angiogenesis in ischemic tissues. The newly discovered mechanism suggests that manipulating it could lead to optimal therapeutic angiogenesis, which may help treat cardiovascular disease.
Blood runs deep: Lab blood vessel model sheds light on angiogenesis
Researchers created a lab model of a blood vessel to study angiogenesis, revealing how the molecule EGFL7 influences blood vessel sprouting and integrity. The study suggests EGFL7 as a potential therapeutic target for diseases like retinopathy and cancer.
New targets found to reduce blood vessel damage in diabetes
Scientists have discovered a new relationship between the enzyme PDIA1 and Drp1 that drives endothelial cell damage in diabetes. Restoring a healthy balance of PDIA1 and Drp1 may provide new treatment targets for diseases associated with endothelial cell senescence.
Sulfur amino acid restriction diet triggers new blood vessel formation in mice
A study from Harvard T.H. Chan School of Public Health found that restricting the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, suggesting improved vascular function may contribute to benefits of dietary restriction.
Blood vessel-on-a-chips show anti-cancer drug effects in human cells
Researchers at the University of Tokyo developed a blood vessel-on-a-chip technology that recreates a human blood vessel and shows how new capillaries grow from a single vessel. The technology can be used to develop drugs targeting angiogenesis, which is a key process in cancer growth.
How new blood vessels sprout
Researchers at IBS and KAIST found that YAP/TAZ promotes cytoskeleton remodeling and junction formation in endothelial cells, essential for normal as well as pathological angiogenesis. Overexpression of YAP/TAZ leads to excessive blood vessel growth, while removal results in vision impairment and internal bleeding.
Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina
Researchers from Mass Eye and Ear successfully prevented mice from developing retinal angiogenesis using CRISPR-Cas9 gene-editing techniques. The technique targets VEGFR2, a critical protein responsible for angiogenesis, and showed promising results in preclinical models.
How blood vessels slow down and accelerate tumor growth
Researchers have found that the Tie2 receptor on pericytes plays a crucial role in regulating blood vessel growth and maturation. By breeding mice with disabled Tie2 receptors, scientists discovered that tumor blood vessels grew faster and more aggressively without this control, highlighting potential new targets for cancer therapy.
Finding new targets to treat vascular damage
Scientists at Joslin Diabetes Center have identified a new molecular pathway that may offer targets for drugs to strengthen angiogenesis and improve blood vessel growth in type 2 diabetes. The study found that CITED2 expression is increased in endothelial cells from patients with diabetes, suggesting its potential as a therapeutic target.
Heart bypass without surgery? -- AGGF1 induces therapeutic angiogenesis through autophagy
Researchers have found that AGGF1 promotes therapeutic angiogenesis through autophagy, increasing the number of mice that survive after acute heart attacks. Treatment with AGGF1 also improves cardiac functions and reduces scarring in the heart.