Articles tagged with Neural Crest
Researchers have discovered that within the first few weeks of development, some embryo cells are already selected to take on particular roles in the peripheral nervous system. This finding overturns longstanding assumptions in biology and opens up new avenues for research into developmental diseases and potential therapies.
A team of researchers at the University of Toronto has discovered a unique stem cell type, the neural crest stem cell, which can be reprogrammed into different cell types. This discovery challenges longstanding theories in cellular reprogramming and highlights the potential of these cells for stem cell transplantation to treat disease.
Researchers have developed a method to differentiate human pluripotent stem cells into cell populations that form patterns resembling the facial primordium. This allows for the creation of an in vitro model to study early facial development and potential treatments for craniofacial disorders.
Researchers at the University of Montana have found a novel method to generate human cartilage using neural crest cells. This breakthrough could lead to effective treatments for repairing craniofacial cartilage damage and improving the lives of 230,000 children born annually with craniofacial defects.
Researchers at the University of Helsinki and NIH found that the ectoderm retains its pluripotency during gastrulation, challenging previous understanding. This discovery sheds light on the chain of events in early embryonic development and has implications for neural crest stem cell potential.
New research suggests neural crest cells retain adaptability even after differentiation, enabling them to 'change their mind' and differentiate anew. This hyper-flexibility has significant implications for regenerative medicine, as these cells have immense potential as treatments to replace and repair damaged body tissue.
Researchers, led by University of Delaware biologist Shuo Wei, have won $1.8 million in NIH support for their study on birth defects caused by genetic mutations in neural crest stem cells. The study focuses on the DDX3X gene and its role in developmental disorders.
A UC Riverside-led research team discovered that neural crest cells originate from the epiblast of chick embryos before the appearance of a definitive ectoderm or mesoderm. This finding provides new insight into the formation of this unique embryonic stem cell population and has implications for human development and health.
Researchers sequenced the genome of 13 ancient Scythian stallions and 1 mare, uncovering diversity in coat coloration patterns and genetic traits valued by breeders. The study suggests that Scythian breeders maintained natural herd structures and selected horses with robust morphologies.
Researchers at Whitehead Institute have identified the pre-mouth array, a region of the developing face that
A new hypothesis proposes that breeding for tameness causes changes in diverse traits, including floppier ears, patches of white fur, and more juvenile faces, due to impaired development or migration of neural crest cells. This unified explanation ties together several components of the domestication syndrome.
Researchers isolated and characterized zebrafish neural crest cells that can differentiate into various cell types, including neurons and melanocytes. The study found that retinoic acid significantly inhibits proliferation but enhances migration in these cells.
A study by Dr. Alexey Terskikh and colleagues found that the SOX2 gene maintains the potential for neural crest stem cells to become neurons in the peripheral nervous system. This discovery could help inform therapies for neurocristopathies, diseases caused by defects in the neural crest or neurons.
Researchers at University of Pennsylvania have discovered a new understanding of how the heart forms in frog embryos. They found that the blood separation comes from an entirely different part of the embryo, known as the 'second heart field'. This finding has implications for human health, particularly for patients with DiGeorge Syndrome.
Researchers at Caltech have discovered intricate gene regulatory networks in various organisms, including fruit flies, nematodes, sea urchins, lampreys, and mice. These networks play a crucial role in directing developmental processes, with subtle balances of regulatory signals being essential for proper cell differentiation.
A new study suggests that embryonic cells giving rise to connective and skeletal tissues of the skull and facial structures do not originate from the neural crest as previously believed. Instead, they come from a distinct thin layer of epidermal epithelial cells next to the neural crest.
Researchers used in vivo cell fate mapping to study the role of TGFbeta signaling in congenital eye disorders. They found that NC-derived cells contribute to various eye structures, and TGFbeta signaling is essential for their proper differentiation and morphogenesis.
Researchers have deciphered a crucial link between genetic microdeletions and DiGeorge syndrome, shedding light on the disease's pathogenesis. The study reveals that TGF signaling plays a pivotal role in neural crest development, which is disrupted in DiGeorge patients leading to characteristic malformations.
Hirschsprung's disease is caused by mutations in genes expressed in neural crest stem cells that impair their ability to form a normal intestinal nervous system. The study identifies Ret and other genes involved in the disease, offering new insights into its causes.
Researchers have discovered stem cells in the adult peripheral nervous system, which can persist into adulthood and give rise to thousands of neurons, glial cells, and smooth muscle cells. This finding has significant implications for understanding the development and repair of the peripheral nervous system.