Articles tagged with Neural Tube
Researchers have developed a new tool to screen genes involved in human development at unprecedented scale and speed. The method, using organoids from human pluripotent stem cells, revealed new insights into human brain development, including the role of ZIC2, SOX11, and ZNF521 genes.
A new study found that warmer nighttime temperatures during pregnancy may be associated with a higher risk of autism diagnosis in children. Exposure to extreme heat during early and late pregnancy increased the risk by 15% and 13%, respectively.
Bioengineering researchers at Harvard John A. Paulson School of Engineering and Applied Sciences developed a soft, thin, stretchable bioelectronic device that can be implanted into a tadpole embryo's neural plate, recording electrical activity from single brain cells with millisecond precision.
Researchers at ISTA used miniature 2D organs and rubbery silicone molds to study morphogen signaling dynamics during spinal cord development. The study found that BMP morphogen signaling gradients emerge quickly, then fade away, only to reappear again, shedding light on the complex process of tissue development.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
New research suggests neural crest cells retain adaptability even after differentiation, enabling them to 'change their mind' and differentiate anew. This hyper-flexibility has significant implications for regenerative medicine, as these cells have immense potential as treatments to replace and repair damaged body tissue.
The UK government's current proposal to fortify flour with folic acid is inadequate, as it suggests a low dose that would fail to prevent hundreds of cases of severe birth defects each year. Increasing the dose could prevent about 80% of neural tube defects.
Weill Cornell Medicine researchers have developed a new approach to analyze genetic mutations associated with spina bifida, shedding light on this complex birth defect. The study uses machine learning to identify genes and molecular pathways relevant to neural tube closure.
Scientists have identified two new candidate genes, ULK4 and PTTG1, that positively influence the development of an embryo by restoring a strong Sonic Hedgehog signaling pathway. This finding provides new insights into the causes of holoprosencephaly, a congenital malformation affecting around one to four in every 1,000 unborns.
Researchers found a redundant network of proteins connecting embryonic cells, enabling tissues to fold into correct shapes even when individual cells are damaged. This discovery sheds light on the robustness of embryonic development and may help understand birth defects like spina bifida.
Research reveals how p53 influences X chromosome inactivation, a critical process for healthy brain and spinal cord formation. This discovery explains why females are more likely than males to be born with neural tube birth defects.
Researchers aim to explore treatment for birth defects like spina bifida and anencephaly by studying how the neural tube closes, with $3.2 million from the NIH. A hybrid microscope combining Brillouin spectroscopy and OCT will help understand mechanical properties controlling neural tube closure in developing embryos.
Researchers found that valproic acid, an antiepileptic drug, can cause birth defects in frog embryos by interfering with glutamate signaling. The study suggests that new epilepsy medications could be developed to be safer for pregnant women.
Researchers found that a transient increase in intracellular calcium ions causes cell deformation and contributes to neural tube formation in African clawed frogs. The pattern of fluctuation in calcium ions is complex, with local and transient rises causing morphological changes.
Researchers found a red blood cell folate concentration range of 1,000 to 1,300 nmol/L may prevent neural tube defects. This biomarker could inform folic acid fortification programs and monitor their success.
Researchers at the University of Colorado Anschutz Medical Campus found that a lack of a specific gene interrupts neural tube closure, a condition that can lead to serious birth defects. The study reveals new insights into neural tube development and opens up a new pathway for understanding how neural tube defects occur.
Researchers at MDC Berlin-Buch have identified a receptor for cholesterol that plays a key role in forebrain development. The study found that defective binding sites can lead to severe anomalies, highlighting the crucial importance of cholesterol metabolism in embryonic development.
A study published in Developmental Cell has identified protease-activated receptors as crucial for neural tube closure, a process disrupted in congenital birth defects such as anencephaly and spina bifida. The research suggests that this PAR signaling system may regulate the integrity of tissue to prevent neural tube defects.
A study published in the New England Journal of Medicine found that adding folic acid to flours significantly reduced congenital neural tube deformation cases in Canada. The incidence dropped from 1.58 per 1,000 births between 1993 and 1997 to 0.86 between 2000 and 2002.
A study published in Nature reveals that a molecular mechanism directs cells to migrate to the correct location within the developing neural tube of vertebrates. The research, conducted by Mount Sinai School of Medicine, identifies specific molecules involved in restoring polarity and guiding cell migration.