Articles tagged with Notochord
Researchers created human stem cell models containing notochord, a tissue guiding spine and nervous system formation. The model's chemical signals organize surrounding tissue similarly to natural development, enabling studies of developmental conditions and disorders.
Researchers at Osaka Metropolitan University found that suppression of Pcdh8 is essential for proper notochord elongation in zebrafish embryos. This study may lead to novel tumor therapies in humans due to the gene's role in controlling cell proliferation.
Researchers have discovered a single-letter change in DNA that alters the way zebrafish build their spines, leading to shorter bodies and tortured-looking spines. This mutation has similarities with fossil specimens of ancestral fish, revealing insights into spine evolution and development.
Researchers study coelacanth specimens at different stages of cranial development, providing new insights into the biology of this iconic animal. The study reveals unique observations about the development of the living coelacanth skull and brain, and opens up new avenues for research on the evolution of vertebrate heads.
Researchers discovered a unique repair mechanism in zebrafish spinal discs that protects fluid-filled cells from mechanical stress and promotes regeneration. The study suggests that this mechanism, triggered by the release of nucleotides, may be present in humans at early stages but is lost over time.
A Yale-led team of paleontologists has determined that the Tully Monster, a 300-million-year-old animal with teeth at the end of a narrow head extension and eyes on either side of a long bar, was a vertebrate with gills and a notochord. The discovery sheds light on the creature's likely predatory lifestyle.
A new study by NYU researchers identifies molecular switches that turn on gene expression in the notochord, a precursor to the backbone. The team used a marine organism called Ciona and found that specific transcription factors bind DNA sequences, known as CRMs, to control gene expression.
Researchers found that a muscle, called axochord, runs along the midline of marine worm Platynereis, similar to where the notochord would be in chordates. This discovery suggests that the notochord may have evolved from a muscle-based structure in an ancient ancestor.
Researchers studied Brachyury gene's role in regulating notochord development, finding CRM mutations affect timing of gene expression. This can lead to birth defects and cancer by delaying critical developmental processes.
Researchers discovered how Brachyury regulates the timing of gene expression in the notochord, a precursor to the backbone, and found that certain mutations can delay or alter this process, potentially leading to birth defects and cancer. The study sheds light on a crucial regulatory mechanism in embryonic development.
Researchers found that embryonic cells from a dog's notochord can regenerate disc cartilage, providing new therapeutic options for degenerative disc disease. The study suggests that CTGF-secreting notochord cells protect non-chondrodystrophic dogs against the condition.
A new study found that copper deficiency in zebrafish leads to birth defects similar to those seen in children with Menkes disease. The researchers discovered a critical role for copper in notochord formation and development, suggesting suboptimal copper metabolism may contribute to structural birth defects.