Articles tagged with Organogenesis
A research team has identified a novel enhancer that controls the tissue-specific expression of Scleraxis, a key transcription factor for tendon, ligament, and entheses formation. The enhancer, capable of recapitulating Scx gene expression in developing limbs, is highly conserved from lobe-finned fishes to tetrapods.
A recent study published in Nature Communications has found that specific cell subtypes are more prone to developing into diabetes. By tracking these subtypes over time, researchers can better understand how they drift over time or under different conditions. The findings hold promise for potential prevention and treatment strategies.
Researchers discovered that nuclei pack strongly, ordering cells into crystalline arrays, and control tissue stiffness. The study challenges the status quo, revealing a new role for nuclei in organ formation.
Researchers at University of Tsukuba have achieved the first successful lab rearing of Hypselodoris festiva, revealing a previously unknown growth process. The study describes nine stages of development, from metamorphosis to adulthood, and provides a reference for further research on Chromodorididae species.
The study reveals that a gene called mTOR, which works like a GPS, directs the specialization of liver cells according to their position. After birth, the fluctuation in nutrient supply triggers the activation of this gene, completing the maturation of the liver.
IPK researchers discovered a universal pattern of internode elongation in barley, dividing the main axis into three subzones. The study identified genetic loci affecting internode length, including the flowering time gene PHOTOPERIOD1, and found that shorter proximal internodes are associated with higher floral organ survival.
Researchers successfully created a rat-derived lung in mouse model using reverse-blastocyst complementation and tetraploid-based organ complementation. The study identified crucial factors required for functional lung formation, including fibroblast growth factor 10 (Fgf10) and its interaction with Fgfr2b.
Researchers found a significant increase in extracellular vesicles released by aged keratinocytes, which were also enriched with specific microRNAs. These EVs impaired young keratinocyte proliferation and organogenesis, mimicking aged skin defects.
Scientists have defined a basic toolkit for forming tubular organs in animals, which is thought to be the foundation of organ development in vertebrates. The study uses the sea star as a model organism and reveals that cells can proliferate and migrate simultaneously during tube formation.
A team of researchers at Kumamoto University successfully created complex 3D kidney tissue in the lab using mouse embryonic stem cells. The breakthrough could lead to advances in kidney research and potentially even transplantable organs.
Researchers at Marshall University discover a sequence in Na/K-ATPase essential for stem cell differentiation and organogenesis. The study provides the first genetic evidence of this functionality, revealing a previously unrecognized common mechanism underlying animal embryonic development.
Analysis found that increased p53 delta113 expression in def-mutant digestive organs leads to cell cycle arrest, reducing organ growth. The p53 isoform's role in hypoplasia of the digestive organs is believed to be significant but not fully understood.