Articles tagged with Segmentation Clock
Scientists discovered that metabolism plays a signalling role during embryonic development, controlling the tempo of growth. By modulating metabolism, they identified a key metabolite FBP regulating the segmentation clock, which impacts spatial patterns of body segments.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Scientists at ASHBi have successfully generated a 3D model that recapitulates the early stages of human body plan development, including somite formation and axial skeleton development. The study revealed the importance of retinoids in this process and demonstrated its potential for understanding congenital spine disease.
A team from Cincinnati Children's Hospital Medical Center discovered how segmentation clock genes instruct the tempo of spine formation, opening doors to new basic science research. By inducing segment formation in zebrafish without biological clocks, the researchers aimed to understand the origins of birth defects in humans.
Researchers from EMBL Barcelona have successfully recreated the formation of human spinal column precursor structures in a laboratory setting. The study reveals that the segmentation clock regulates somitogenesis and that somite size is species-specific.
EMBL scientists examined the molecular causes of a rare hereditary disease of the spine and ribs, revealing that errors in the segmentation clock can cause disorders. The researchers created a lab system to study this process, demonstrating that specific gene mutations, such as DLL3, are responsible for the condition.
Researchers at Kyoto University have successfully reconstructed the human segmentation clock using induced pluripotent stem cells (iPSCs), a key focus of embryonic development research. The study reveals novel genetic components and oscillation patterns of the clock, which controls the formation of organs and tissues.
A team of researchers has developed a laboratory model for vertebral development, allowing them to study the human segmentation clock and its role in forming the spinal column. The model reveals that the clock controls the periodic activation of molecular signaling pathways, leading to the formation of vertebrae.
Scientists have unveiled the first lab-dish models of human spine development, providing evidence of the segmentation clock in humans. The models allow for the study of early spine development and could lead to new treatments for conditions such as congenital scoliosis.
A team of researchers at Harvard Medical School has created a stable version of the segmentation clock in a petri dish, revealing its dynamic nature and control mechanisms. The discovery could lead to improved understanding of scoliosis and other human spinal defects.
The Pourquié Lab has linked Beta-catenin to the process of somite formation, a critical step in vertebral column development. Increasing Beta-catenin levels alters mesoderm maturation and corresponds with oscillations of the segmentation clock.
A research team discovered the Notch signaling pathway is responsible for the chick embryo's periodic production of somites, which are precursors to vertebrae. Abnormalities in this process can lead to severe vertebral column defects and scoliosis.