Tumor Development
Articles tagged with Tumor Development
New targeted therapy shows promise against aggressive childhood and adult cancers
A new targeted therapy has shown strong results in preclinical studies against aggressive childhood and adult cancers, eliminating tumours and stopping cancer spread. The therapy targets the IL1RAP protein, which is found on cancer cells but largely absent from normal tissues, allowing for precise delivery of treatment.
How to remove a metabolic tattoo
A team of Kyoto University researchers found that exposure to high-fat diets induces persistent metabolic stress in killer T cells, but also discovered a pathway for protection through purine metabolism. By recycling xanthine, killer T cells can produce antioxidants to boost their ability to fight tumors.
Trends and disparities in the use of next-generation sequencing in patients with cancer in the US
Advanced or metastatic cancers often go without tumor genomic testing, with those from low-income backgrounds facing longer wait times. JAMA Network Open highlights the need for targeted healthcare policies to bridge these gaps.
Discovery about aging and cancer opens the door to better targeted treatments
Researchers at the University of Gothenburg have identified a protein, ATF4, linked to increased metastasis and recurrence in lung cancer. The study reveals that older individuals' tumors are smaller and grow more slowly, yet more likely to have spread when detected.
Dresden study uncovers new key mechanism in cancer cells
The study reveals that MCL1 directly influences the mTORC1 complex, controlling bioenergetics and tumorigenesis in cancer cells. Genetic analyses also show that MCL1 inhibitors inhibit mTOR signaling, addressing a previously unresolved problem in cancer therapy.
Nasal therapeutic vaccine for treating cervical cancer
Researchers at Chiba University have developed a nasal therapeutic vaccine targeting E7 oncoprotein, which is produced by high-risk strains of HPV associated with cervical cancer. The vaccine triggers an immune response in the cervical mucosa, providing local protection against pathogens and foreign particles.
Inflammation may be responsible for driving earliest stages of lung cancer
Researchers at University of Texas M. D. Anderson Cancer Center discover that inflammation is responsible for driving the earliest stages of lung cancer, identifying potential targets for early intervention and suggesting a promising approach to intercepting lung cancer development.
Lighting up life: Rice scientists develop glowing sensors to track cellular changes as they happen
Researchers at Rice University have engineered living cells to use a 21st amino acid that illuminates protein changes in real time, providing a new perspective on the inner workings of life. This breakthrough addresses a long-standing challenge in biology by allowing scientists to track subtle protein changes within living systems.
Social adversity and triple-negative breast cancer incidence among black women
A cohort study reveals a significant association between social adversity and increased incidence of triple-negative breast cancer in Black women. The findings suggest potential social genomic and gene-environment interactions that contribute to disparities in breast cancer survival.
Decoding the secrets of ‘chemo brain’
Researchers suggest chemotherapy drugs may be responsible for 'chemo brain' symptoms, citing reduced lymphatic vessel growth and impaired cognitive function. The study highlights the need to consider long-term neurological side effects of cancer treatment on quality of life.
Study finds restoring order to dividing cancer cells may prevent metastasis
Researchers discovered that an enzyme called EZH2 drives triple negative breast cancer cells to divide abnormally, enabling them to spread. Inhibiting EZH2 with drugs like tazemetostat restored order to dividing cells and thwarted the spread of TNBC cells.
Penn Engineers explore how tumor mechanics and tiny messengers could shape the future of cancer research
The study highlights connections between tumor mechanics and extracellular vesicles, which may not be as different as they seem. Researchers are now investigating the interplay between mechanics and messaging in cancer progression.
Wired to grow: How small cell lung cancer hijacks neuronal synapses
Researchers found that lung cancer cells can form functional synapses with neurons, supporting their growth and survival. Disrupting glutamate signalling led to lower tumour burden and longer survival in experimental mice, highlighting promising therapeutic targets.
Wilms tumors: How genes and imprinting pave the way for cancer
A study published in Genome Medicine has identified the underlying predisposition for Wilms' tumors, highlighting the role of mutations in tumor suppressor genes like WT1. The research also reveals a significant proportion of childhood kidney tumors have a hereditary component, with implications for genetic counseling and monitoring.
Early immune evasion found in HPV-related pre-cancer lesions of the anogenital region
Researchers found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of immune-related markers PD-L1 and FOXP3. These findings suggest that HPV may begin avoiding the immune system early in infection, allowing infected cells to grow and potentially leading to cancer.
Top medical research expert Mark T. Esser named inaugural head of UVA’s Manning Institute
The University of Virginia has appointed Dr. Mark T. Esser as the inaugural head of its Manning Institute, a $350 million facility aimed at transforming healthcare and accelerating new treatments. Esser brings decades of experience in developing new medical breakthroughs and will foster an ecosystem of innovation to attract biotechnolo...
circTP63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway
A novel circular RNA, circTP63-N, generated by back-splicing exons 2–4 of the TP63 gene is significantly downregulated in nasopharyngeal carcinoma (NPC) tissues. Restoring its expression effectively inhibits NPC cell proliferation and metastasis via engagement with HSP90AB1 to modulate the YAP1/Hippo signaling pathway.
Cellular changes occur even below the hexavalent chromium limit
Researchers found significant cell changes in workers exposed to hexavalent chromium at levels below Sweden's current limit. The study suggests the need for stricter safety regulations and lower limits for this carcinogenic substance.
Growing body of evidence links HPV with heart disease
A growing body of evidence suggests a significant link between human papillomavirus (HPV) and heart disease. Researchers pooled data from nearly 250,000 patients in seven studies, finding HPV-positive individuals had a 40% higher likelihood of developing cardiovascular disease.
The secret DNA circles fueling pancreatic cancer’s aggression
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
The development of a risk prediction model to predict patients’ likelihood of completing human papillomavirus vaccination
A risk prediction model was developed to identify patients unlikely to complete HPV vaccination. The model uses patient demographics and clinical characteristics to guide targeted interventions, increasing vaccination rates among high-risk groups.
Cold sore discovery IDs unknown trigger for those annoying flare-ups
Scientists have identified a new target to prevent cold sores by understanding how the herpes virus triggers its own immune response. The discovery has important implications for genital herpes caused by the same virus, with potential treatments in development.
New technique reveals how the same mutations give rise to very different types of leukaemia
A new study has identified two cell types with distinct biological properties that respond differently to treatment after acquiring the same mutation. Understanding these differences is crucial for developing personalized therapies and preventing aggressive forms of cancer.
Research challenges our understanding of cancer predisposition
Researchers found genetic changes not exclusive to tumours and skin patches, suggesting additional factors are necessary for tumour development. The study identified a pattern of mutations in the NF1 gene that may explain why nervous system tissues are commonly affected.
Project Cure CRC ignites innovation in 2025 with $10.5 million in research, K-SPY debut & renewed RFP
The Colorectal Cancer Alliance has awarded new grants to researchers, convened top scientists at the Cure CRC Summit, and launched K-SPY, a groundbreaking multi-center platform trial for high-risk colorectal cancer cases. The initiative aims to improve outcomes for millions affected by the disease.
JMC | Insilico Medicine unveils novel AI-driven FGFR2/3 inhibitor to overcome resistance tumor mutations
Insilico Medicine has developed a highly selective FGFR2/3 dual inhibitor, which maintains efficacy against resistance mutations and demonstrates a more favorable safety profile compared to existing FGFR inhibitors. The compound showed robust antitumor efficacy in gastric cancer mouse models.
Route of entry for Semliki Forest virus into the brain revealed
Researchers at Uppsala University found that Semliki Forest virus penetrates the central nervous system by entering the cerebrospinal fluid and binding to VLDLR before penetrating deeper into the brain. This finding could be used to develop the virus as an agent for treating brain cancer.
KAIST develops foundational technology to revert cancer cells to normal cells
Researchers at KAIST have developed a technology that can treat colon cancer by converting cancer cells into normal-like cells. The breakthrough involves creating a digital twin of the gene network associated with normal cell differentiation, leading to significant promise for reversible cancer therapies.
Dr. Direna Alonso-Curbelo receives an ERC Consolidator Grant to study how inflammation fuels tumor initiation and evolution
Dr. Direna Alonso-Curbelo's ERC Consolidator Grant project, IGNITE, aims to unravel the complex interplay between genetic and non-genetic factors that ignite tumor development. The research focuses on understanding how inflammation drives pancreatic cancer initiation and progression.
Mathematical modelling leads to a better understanding of prostate cancer
A new mathematical model of prostate cancer has been developed, revealing key findings on genetic changes and tumour growth. The study shows that strong genetic changes are necessary for aggressive tumours to develop early in the course of tumour development.
New genetic changes linked to testicular cancer offer fresh insights into the disease and its treatment
Testicular cancer is a highly treatable condition with high survival rates when detected early, but patients with the highest-risk disease face a lower prognosis. New genetic changes have been identified using whole genome sequencing, offering potential new treatment strategies.
Protein degradation strategy offers new hope in cancer therapy
Researchers at UC Riverside develop a novel method to degrade the Pin1 protein, which is involved in pancreatic cancer development. The 'molecular crowbar' strategy has the potential to target and break down harmful proteins, offering new hope for cancer therapy.
USC study explores new insights into innate resistance for immunotherapies in colorectal cancer
Researchers found higher levels of CD47 expression linked to more aggressive tumors, immune cells, and oncogenic signaling. Targeting CD47 could lead to improved outcomes with immunotherapy drugs, especially in cases where existing treatments are ineffective.
Molecular chaperones: Guardians of tumor suppressor stability
Research highlights molecular chaperones' role in maintaining tumor suppressor stability and functional integrity. This understanding is crucial for developing targeted therapies for multiple cancers.
Breakthrough study reveals how mutant p53 protein converts other proteins into cancer drivers
Researchers have uncovered a critical mechanism by which mutant p53 protein converts other proteins into cancer-promoting agents, driving tumor growth. Heparin, a widely used anticoagulant, can inhibit the formation of these harmful aggregates, providing a potential therapeutic approach.
Dine on DNA: Compounds from nucleic acids in food show anticancer effects
Researchers at Osaka Metropolitan University found compounds in nucleic acids from salmon DNA and torula yeast RNA inhibit cancer cell growth. These compounds may prevent cancer by stopping cell replication.
Study reveals the benefits and downside of fasting
A new study reveals that fasting helps regenerate and heal intestinal injuries, but also increases the risk of developing early-stage intestinal tumors in mice. The researchers identified a pathway enabling this enhanced regeneration, which is activated during refeeding after fasting.
Chinese Medical Journal study charts the incidence and mortality of digestive system cancers
The study analyzes six major digestive system cancers worldwide and in China, revealing correlations between country HDI and cancer prevalence. Colorectal cancer is the most prevalent, while Asia accounts for 60.5% of new gastrointestinal cancer cases globally.
Advancing towards a novel, highly accurate method for cervical cancer screening
A research team has identified novel biomarkers in cervical mucus samples that show high diagnostic power for detecting cervical cancer. The findings suggest that analyzing local expression levels may offer a superior diagnostic strategy, potentially reducing the need for invasive procedures.
Gut microbes implicated in bladder cancer
A study by EMBL researchers found that gut bacteria can convert carcinogenic chemicals like BBN into BCPN, leading to tumour formation. The team discovered 12 bacterial species involved in this process, with individual differences in human gut microbiome affecting the risk of cancer development.
New findings on possible therapies to target oncogenic transcription factors in multiple cancer types
A new study from Michigan Medicine suggests that inhibiting the SWI/SNF epigenetic complex can therapeutically target oncogenic transcription factors. The research, led by Arul Chinnaiyan, builds on previous work to find genetic vulnerabilities in transcription factor-driven cancers.
Combination of drugs produces promising results in combating cancer and will be clinically trialed in Europe
Researchers developed a new approach to combat cancer by hyperactivating tumor cells, making them stressed and vulnerable to specific drugs. The combination strategy showed promising results in colorectal and pancreatic adenocarcinoma models, paving the way for potential treatment options.
Key driver for epithelial cancer development identified
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
Novel blood test helps improve cancer treatments
A new liquid biopsy method analyzes gene fragments in the bloodstream to detect and track cancer, enabling oncologists to tailor treatment approaches to individual patients. This non-invasive test can help monitor treatment success, detect cancer recurrence, and improve patient quality of life.
Study led by NTU Singapore and Chiba University finds that a common virus can trigger quicker growth of nasopharyngeal cancer
Scientists discover Epstein-Barr virus alters gene regulation in nasopharyngeal cancer cells, leading to rapid tumour growth. The study offers new insights into the link between EBV and NPC, shedding light on intricate processes underlying disease progression.
PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors (PARs)
The study highlights the importance of protease-activated receptors (PARs) in cancer growth and development, with PH-binding motifs identified as a key platform for drug design. The researchers suggest that targeting PARs could provide an alternative to current oncogenic pathways.
New biomarkers of response in melanoma immunotherapy
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
A new mechanical transducer was revealed
Researchers have uncovered a novel regulator governing how cells respond to mechanical cues, finding that ETV4 bridges cell density dynamics to stem cell differentiation. This discovery has significant implications for controlling cancer cells through mechanical cues.
The key role of Galectin-3 in brain tumour development
Researchers at the University of Seville discovered Galectin-3's crucial role in brain tumour progression, finding its inhibition significantly reduces glioblastoma size and brain metastases. Inhibition promotes pro-inflammatory markers and reverses immunosuppressive biomarkers, leading to improved outcomes.
Researchers discover urine-based test to detect head and neck cancer
Researchers have developed a urine-based test that detects pieces of DNA fragments released by head and neck tumors, providing a non-invasive alternative to traditional blood-based biomarker tests. The test has been shown to detect cancer recurrences far earlier than would typically happen based on clinical imaging.
“Concerning” disparities in HP vaccine uptake among US adults, with men and Hispanic people among those least protected
Low HPV vaccine uptake among US adults aged 27-45 is a concern, particularly for men and Hispanic individuals. Experts stress the need to address disparities in vaccination rates to prevent cancer cases.
Bacteria commonly found in the body contribute to stomach cancer, finds study co-led by NTU Singapore
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
How do viruses choose whether to become nasty or not?
Researchers deciphered a novel process helping viruses choose to be nasty or friendly to their host bacteria. Phages use the bacterial immune system to make decisions, activating violent mode when necessary.
Scientists unravel mystery of drug response in small cell lung cancer
A research team at the University of Cologne has identified mechanisms governing drug response in small cell lung cancer. The study reveals that large populations of treatment-sensitive cells often hide numerous therapy-resistant cells that can multiply unchecked after successful treatment.
Sting operation out of gas
Researchers question whether micronuclei activate the cGAS-STING pathway, a key innate immune response to foreign nucleic acids. The study found that MN more commonly recognizes DNA during cell division without triggering STING activation.
Eating habits, physical activity practice and clinical prognosis of colorectal cancer patients with overweight/obesity
A recent study investigated eating habits and physical activity in colorectal cancer (CRC) patients with overweight/obesity. The results show that these patients have higher prevalence of metastasis, recurrence, and death compared to eutrophic patients.
HPV’s hidden hand: New study by Pusan National University scientists reveals key details in head and neck cancer microenvironment
A recent study by Pusan National University scientists discovered the crucial role of PKM gene and EPHA2 pathway in HNSCC development. The research highlights the importance of HPV infection status in shaping the tumor microenvironment, enabling precision medicine for targeted treatment.
Cleveland Clinic research reveals a process tumors use to induce immune suppressor cells and evade immunotherapy
Researchers discovered that VISTA induces immune suppressor cells called myeloid-derived suppressor cells (MDSCs) through a feedback loop involving STAT3 and polyamines. This pathway has high translational impact for several human cancers, offering promising drug targets.
Alterations in the blood immune system found to increase cancer risk
Researchers have found that alterations in the blood immune system increase cancer risk, and identified over 1,000 genes influencing this regulation. The study also discovered protective roles of certain immune cells against common cancers.