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UT MD Anderson shares latest research breakthroughs

Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.

Imaging tool reveals novel insights into DNA replication stress response

Researchers developed RF-SIRF, a quantitative method to detect and map reversed DNA replication forks with single-cell resolution. The study identified unique epigenetic codes for DNA replication stress that can be further examined to understand genomic stability, aging, and treatment response.

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Toxic exposure creates epigenetic disease risk over 20 generations

A new study found that a single toxic fungicide exposure during pregnancy can increase the risk of disease for 20 subsequent generations, with inherited health problems worsening over time. The study suggests that epigenetic disease inheritance could help explain rising chronic disease rates in humans.

Wasps may hold the secret to slowing down the ageing process

Scientists at the University of Leicester discovered that jewel wasps can slow down their biological rate of ageing by undergoing a natural 'time-out' as larvae. This pause in development extends lifespan and decelerates the epigenetic clock, tracking chemical changes in DNA.

Understanding the epigenetic mechanisms behind premature aging of the brain

A recent study published in The EMBO Journal reveals that the Setd8 gene plays a critical role in the premature aging of the brain by controlling neural stem cell activity and proliferation. Artificially lowering Setd8 levels mimicked molecular signatures of aging, highlighting its potential as a biomarker for early aging.

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Scientists use cellular programming to mimic first days of embryonic development

Researchers at UC Santa Cruz engineered cellular models of embryos using CRISPR technology, allowing them to study early developmental stages without experimenting with actual embryos. The team found that 80% of stem cells organized into embryo-like structures, showcasing a remarkable collective behavior and molecular composition.

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An epigenetic approach to modulating aging with nutrition and exercise

Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.

Post-COVID syndrome visible in DNA

Researchers found epigenetic changes in post-COVID patients, including genes associated with taste and smell, as well as cell metabolism. These findings may lead to the development of new diagnostic tools for this and similar diseases.

New research furthers case for exercise promoting youthfulness

Exercise promotes a molecular profile consistent with expression of youthfulness-promoting Yamanaka factors, according to a recent study published in the Journal of Physiology. The researchers found that exercise induces Myc protein in muscle, which may serve as a naturally induced reprogramming stimulus.

A ‘factory reset’ for the brain cures anxiety, drinking behavior

Researchers at the University of Illinois Chicago found that gene editing can reverse epigenetic changes in the brain caused by adolescent binge drinking, leading to a decrease in anxiety and excessive drinking behavior. The study used CRISPR-dCas9 technology to manipulate histone acetylation and methylation processes at the Arc gene.

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Early estrogen exposure leads to later prostate cancer risk

A study found that early exposure to estrogen or BPA increases the risk of precancerous lesions in the prostate. Researchers discovered that this leads to epigenetic reprogramming, altering gene expression patterns that promote prostate disease with aging.