Articles tagged with Epigenetics
A 12-month exercise intervention improved attention and memory in breast cancer survivors, while a companion study found exercise slowed epigenetic aging. These findings suggest exercise may help buffer against cognitive effects associated with accelerated epigenetic aging.
Researchers identified circLPAR3 as a key mediator of docetaxel resistance in prostate cancer, promoting tumor growth under chemotherapy by suppressing ferroptosis. The study highlights circLPAR3 as a promising biomarker for treatment response and suggests targeting its regulatory network could help overcome chemotherapy resistance.
Scientists discovered that a temporary change in gene regulation can be inherited for at least 15 generations in C. elegans without altering the DNA sequence. This epigenetic inheritance occurs through a succession of mechanisms, allowing organisms to respond to changing environmental conditions.
A UCLA study found that a dietary supplement, Ca-αKG, reduced lung tumor growth in female mice, but increased tumor growth in male mice. The supplement activated genes associated with better outcomes in women with lung cancer, but had the opposite effect in men.
Researchers at St. Jude Children's Research Hospital discovered that KDM2B is essential for tumor growth in Group 3 and Group 4 medulloblastomas, which lack targeted therapies. Removing KDM2B or its downstream complexes slowed tumor growth and prolonged survival in preclinical models.
A phase 2 trial found that vitamin C may benefit people with pre-cancer blood disorders by altering inflammatory signaling molecules and reducing adverse events. The study suggests that vitamin C may help regulate inflammatory pathways associated with growth and progression of pre-cancerous blood cells.
A new study found that inducing mitochondrial reactive oxygen species (ROS) during embryonic development protects the adult heart from chemotherapy toxicity in mice. The study discovered that stressed mitochondria release citrate, leading to long-term epigenetic changes that promote beneficial mitohormetic adaptations. These findings s...
Salk Institute scientists found that maternal immune activation leads to epigenetic changes in mouse brains, increasing the risk of neurodevelopmental disorders. These changes were particularly significant in areas of the genome associated with autism spectrum disorder.
Epigenetic regulation governs chromatin accessibility and transcriptional output, enabling cells to adopt distinct functional states. The review discusses the importance of epigenetic mechanisms in development, disease and therapy, highlighting their potential for clinical translation.
Two new studies from Karolinska Institutet suggest that inflammation and genetic factors may contribute to cluster headache, a rare neurological disorder characterized by severe headache attacks. The studies also found that exposure to substances in tobacco smoke may interact with biological mechanisms in the condition.
Researchers at Van Andel Institute discovered that Legionella bacteria use a protein called RomA to manipulate the host's epigenetic landscape, allowing it to survive and multiply. However, this manipulation is also subject to the host's rules, revealing a complex two-way conversation between host and pathogen.
A new blood-based approach developed by Kumamoto University researchers detects breast cancer recurrence by analyzing nucleosome structure in circulating DNA. The study identified genomic regions associated with treatment resistance and recurrence, promising a low-invasive monitoring method for patients.
Researchers have maintained brain organoids for over 5 years, mirroring human brain development. The tissue exhibits complex cellular interactions, neuronal activity, and epigenetic changes, providing insights into neurodevelopment and potential therapeutic targets.
A new study at Tampere University found that simple risk factors like body mass index, waist-to-hip ratio, and smoking habits are better predictors of chronic disease than epigenetic clocks. This challenges the marketing claims of biological age tests, which can cost hundreds of euros.
Researchers discovered that maternal age effects are driven by an epigenetic mechanism, specifically histone modifications, which can turn gene expression on or off. This mechanism can rapidly reverse effects, implying that maternal age effects are not caused by gradual accumulation of cellular damage.
Researchers from USC-led study found that different epigenetic clocks capture distinct aspects of cellular aging, while introducing new gene-expression based clocks with stronger predictive power. These tools can better predict age-related disease and mortality by examining DNA methylation patterns and gene expression.
Researchers found that OSKTF-mediated neuronal rejuvenation boosts rehabilitation-driven corticospinal tract (CST) repair after ischemic stroke. The study demonstrated that combining OSKTF expression with rehabilitative training significantly enhances CST axon sprouting and skilled locomotor function recovery.
A cohort study finds that childhood history of maltreatment is associated with increased biological age in late midlife, potentially impacting health outcomes. The study's epigenetic clock analysis sheds light on the long-term effects of early life trauma on aging processes.
Research at AIST, Institute of Science Tokyo, and Ritsumeikan University uncovers the impact of histone acetylation site location on liquid–liquid phase separation in gene regulation. This study provides new perspectives for therapeutic development targeting aberrant gene expression.
A vegan diet for one month shifts epigenetic patterns associated with reduced inflammation, immune function, and biological aging. The study found changes in DNA methylation linked to lower proportions of inflammatory immune cells and increased proportions of CD4 T cells.
A new study found that cells of the same chronological age can follow dramatically different biological aging paths. Tissues become a mosaic of biologically younger and older cells, with some individual cells aging much faster than others.
Researchers have developed a genetic tool, mCHIRA, to study the effects of small sequence variations on gene regulation and tease apart the impact of genomic microenvironment. This approach enables scientists to test hundreds of regulatory DNA sequences and understand how cells determine which genes are active.
A study of 43 fathers, mothers, and newborns found that higher ultra-processed food consumption by fathers was associated with higher birth weights and greater fat accumulation in babies. The quality of the father's diet before conception may influence fetal development.
Researchers found that females with live offspring had lower late-life frailty, contradicting previous theories on a potential reproductive cost. The study used companion dogs to investigate the relationship between reproduction and aging, revealing a unique link between parity and robustness.
The IRP1/ARID3A complex suppresses ferroptosis and promotes chemoresistance in pancreatic cancer by epigenetically silencing cytoglobin (CYGB). Restoration of CYGB expression reverses these effects, sensitizing tumor cells to ferroptosis and improving treatment outcomes.
Researchers at Nagoya University review the latest results of plasma agriculture, finding that well-tuned plasma treatments boost seed vigor or yield in over two-thirds of studies. Plasma-induced epigenetic changes also promote positive expression of plant genes involved in germination and stress tolerance.
Researchers at Rockefeller University discovered that MLL4 drives disease progression in specific leukemia types while acting as a tumor suppressant in solid tumors. The findings provide new insights into the molecular mechanisms underlying MLL4's context-dependent functions in cancer.
Researchers have developed a new CRISPR-based method to control protein production in cells by targeting ribosomal RNA. This method, known as TAPIR, has been shown to increase protein synthesis and promote the growth of cancer cells. The results offer new insights into stem cell biology and disease-relevant processes.
A large study suggests exposure to air pollution during sperm development can impact genes associated with sperm development, chromosomal organisation and cellular quality control. Researchers identified 39 DNA methylation changes linked to air pollution mixtures, including ozone and nitrogen dioxide.
Recent studies suggest that p16INK4a+ cells, previously thought to be non-beneficial due to their association with aging, actually contribute to tendon regeneration. These mesenchymal cells produce collagen and factors promoting new blood vessel and nerve growth, crucial for normal tendon function.
Researchers discovered how ATRX mutations reprogram gene regulation architecture to fuel glioma growth and progression. Targeting genes downstream of ATRX slowed cancer progression in preclinical models.
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
Researchers at the University of Zurich have developed epigenetic drugs that can reprogram perivascular fat cells to reduce inflammation and improve blood vessel health. By targeting specific gene-expression regulators, these drugs aim to prevent vascular damage in people with obesity and metabolic disease.
Researchers at ISTA and Norwegian Institute of Public Health found that environmental factors influenced by parents' genes can significantly impact children's traits like height, body weight, and school performance. The study used genetic and phenotypic data from over 30,000 families to separate direct and indirect genetic effects.
Researchers found a unique protein called YAF9B that helps plants protect their stem cells from DNA damage. This discovery sheds light on how plants coordinate DNA repair processes, which could improve future crops by guiding more precise genome editing.
Researchers at the University of Pittsburgh School of Medicine discovered an unexpected chromosome interaction between telomeres and centromeres in some aggressive cancers. This interaction creates a genetic signature that could help identify ALT-positive tumors, which are often challenging to treat due to genomic instability.
A recent study found that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in adults with HIV. The treatment reduced chronic immune activation, visceral and ectopic fat, and reprogrammed certain cells, which may help explain its effects on multiple aging clocks.
Researchers discovered that certain organelles in plants can efficiently compensate for mistranslated proteins, a key to their environmental stress acclimation. Plants tolerate high rates of plastid mistranslation via regulated proteostasis.
A recent study by UAB and IJC reveals that SIRT7 plays a crucial role in maintaining the genome stability of male germ cells. The protein's deficiency during ageing leads to functional decline in sperm quality, causing premature loss of spermatogonia and increased DNA fragmentation.
A new study reveals that metabolic dysfunction in offspring is caused by excess microRNA in sperm from obese fathers. After weight loss, these molecular marks disappear, and offspring develop normally. Research suggests that interventions promoting health and longevity may trigger an increase in this enzyme expression.
A recent study by University of California - Davis researchers has identified a protein called DAXX that guides the packing and folding of DNA in sperm cells. This discovery could improve treatments for couples struggling with male infertility, as well as help understand how environmental factors impact offspring health.
Researchers at Bar-Ilan University restored youthful patterns of DNA organization in old mice livers, reversing molecular signs of aging. The study identifies SIRT6 as a powerful protector against age-related chromatin changes.
Researchers from The University of Osaka have discovered a two-factor system that controls stem cell differentiation, involving the stabilization of the CoREST corepressor complex at gene promoters. This process prevents stem cells from drifting towards differentiation and maintaining their pluripotency.
Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.
Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.
Researchers developed a new framework, 'Mollifier Layers,' to tackle challenging inverse PDEs. This advance could benefit fields such as genetics and weather forecasting by inferring hidden forces that produce observable patterns.
A specific region of Dicer must be activated to achieve proper cell division and reproduction, a discovery that sheds light on the regulation of this enzyme's critical role in both cancer biology and fertility. This finding opens new avenues for studying how small epigenetic changes contribute to disease.
Researchers mapped epigenome changes in cells that regulate blood sugar levels, finding patterns differ between people with and without type 2 diabetes. Epigenetic alterations impact insulin-producing beta cells, leading to impaired energy production and reduced insulin release.
A new study found that every type of epigenome protein produces a distinct pattern of gene expression, surpassing the on/off switch functionality. This discovery has significant implications for cellular engineering, enabling more dynamic control over cellular behavior and potential applications in biomanufacturing and bioproduction.
Dr. Eric Richards, a professor at BTI, has been awarded a 2026 Guggenheim Fellowship to investigate Daniel MacDougal's pioneering work on ovarial injection experiments in plant genetics. He aims to use archival research and modern DNA sequencing to determine if MacDougal's protocol actually created mutations.
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
A study found that epigenetic changes present at birth can impact an infant's gut microbiome development during their first year. The researchers also identified specific epigenetic changes and gut microbes associated with signs of autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD).
Researchers at UT MD Anderson have made significant advancements in cancer care, including a blood-based biomarker for cancer risk in people with Lynch Syndrome and a new target to sensitize pancreatic tumors to immunotherapy. The studies also identified a strategy to overcome radiation therapy resistance in lung cancer.
A recent study reveals that linker histone H1 binds to nucleosomes and creates a dynamic, flexible network that condenses chromatin. This new understanding suggests that chromatin behaves like a liquid-like 'glue' rather than a rigid structure.
A study published in Cancer Research has identified DPY30 as an epigenetic target that can sensitize pancreatic tumors to immunotherapy. By modulating DNA replication stress, DPY30 promotes the addition of activation signals at stressed replication forks, supporting cancer cell survival and proliferation.
Research in mice reveals direct gene regulation by alcohol metabolites, with varying effects on brain regions and exposure durations. Short-term exposure influences more genes and epigenetic programs compared to lengthy exposure.
A study in mice reveals that chronic intestinal inflammation can lead to epigenetic 'memories' that promote colon cancer. Researchers found that even seemingly healed gut tissues retain molecular scars from earlier inflammation, making it easier for cancer to take hold.
Researchers found that penguins living in zoos with regular food access and limited physical activity age faster, but live longer than those in the wild. The study reveals a link between zoo conditions and accelerated aging mechanisms.
The São Paulo School of Advanced Science in Obesity will provide graduate students and early career researchers with a two-week training program on obesity research and prevention. The school will feature renowned keynote speakers and cover topics such as epidemiological aspects, genetic nutrition, epigenetics, and emerging preventive ...
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.