Articles tagged with Epigenetics
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
Researchers at ISTA and Norwegian Institute of Public Health found that environmental factors influenced by parents' genes can significantly impact children's traits like height, body weight, and school performance. The study used genetic and phenotypic data from over 30,000 families to separate direct and indirect genetic effects.
Researchers found a unique protein called YAF9B that helps plants protect their stem cells from DNA damage. This discovery sheds light on how plants coordinate DNA repair processes, which could improve future crops by guiding more precise genome editing.
Researchers at the University of Pittsburgh School of Medicine discovered an unexpected chromosome interaction between telomeres and centromeres in some aggressive cancers. This interaction creates a genetic signature that could help identify ALT-positive tumors, which are often challenging to treat due to genomic instability.
A recent study found that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in adults with HIV. The treatment reduced chronic immune activation, visceral and ectopic fat, and reprogrammed certain cells, which may help explain its effects on multiple aging clocks.
Researchers discovered that certain organelles in plants can efficiently compensate for mistranslated proteins, a key to their environmental stress acclimation. Plants tolerate high rates of plastid mistranslation via regulated proteostasis.
A recent study by UAB and IJC reveals that SIRT7 plays a crucial role in maintaining the genome stability of male germ cells. The protein's deficiency during ageing leads to functional decline in sperm quality, causing premature loss of spermatogonia and increased DNA fragmentation.
A new study reveals that metabolic dysfunction in offspring is caused by excess microRNA in sperm from obese fathers. After weight loss, these molecular marks disappear, and offspring develop normally. Research suggests that interventions promoting health and longevity may trigger an increase in this enzyme expression.
A recent study by University of California - Davis researchers has identified a protein called DAXX that guides the packing and folding of DNA in sperm cells. This discovery could improve treatments for couples struggling with male infertility, as well as help understand how environmental factors impact offspring health.
Researchers at Bar-Ilan University restored youthful patterns of DNA organization in old mice livers, reversing molecular signs of aging. The study identifies SIRT6 as a powerful protector against age-related chromatin changes.
Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.
Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.
Researchers developed a new framework, 'Mollifier Layers,' to tackle challenging inverse PDEs. This advance could benefit fields such as genetics and weather forecasting by inferring hidden forces that produce observable patterns.
A specific region of Dicer must be activated to achieve proper cell division and reproduction, a discovery that sheds light on the regulation of this enzyme's critical role in both cancer biology and fertility. This finding opens new avenues for studying how small epigenetic changes contribute to disease.
Researchers mapped epigenome changes in cells that regulate blood sugar levels, finding patterns differ between people with and without type 2 diabetes. Epigenetic alterations impact insulin-producing beta cells, leading to impaired energy production and reduced insulin release.
A new study found that every type of epigenome protein produces a distinct pattern of gene expression, surpassing the on/off switch functionality. This discovery has significant implications for cellular engineering, enabling more dynamic control over cellular behavior and potential applications in biomanufacturing and bioproduction.
Dr. Eric Richards, a professor at BTI, has been awarded a 2026 Guggenheim Fellowship to investigate Daniel MacDougal's pioneering work on ovarial injection experiments in plant genetics. He aims to use archival research and modern DNA sequencing to determine if MacDougal's protocol actually created mutations.
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
A study found that epigenetic changes present at birth can impact an infant's gut microbiome development during their first year. The researchers also identified specific epigenetic changes and gut microbes associated with signs of autism spectrum disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD).
Researchers at UT MD Anderson have made significant advancements in cancer care, including a blood-based biomarker for cancer risk in people with Lynch Syndrome and a new target to sensitize pancreatic tumors to immunotherapy. The studies also identified a strategy to overcome radiation therapy resistance in lung cancer.
A recent study reveals that linker histone H1 binds to nucleosomes and creates a dynamic, flexible network that condenses chromatin. This new understanding suggests that chromatin behaves like a liquid-like 'glue' rather than a rigid structure.
A study published in Cancer Research has identified DPY30 as an epigenetic target that can sensitize pancreatic tumors to immunotherapy. By modulating DNA replication stress, DPY30 promotes the addition of activation signals at stressed replication forks, supporting cancer cell survival and proliferation.
Research in mice reveals direct gene regulation by alcohol metabolites, with varying effects on brain regions and exposure durations. Short-term exposure influences more genes and epigenetic programs compared to lengthy exposure.
A study in mice reveals that chronic intestinal inflammation can lead to epigenetic 'memories' that promote colon cancer. Researchers found that even seemingly healed gut tissues retain molecular scars from earlier inflammation, making it easier for cancer to take hold.
Researchers found that penguins living in zoos with regular food access and limited physical activity age faster, but live longer than those in the wild. The study reveals a link between zoo conditions and accelerated aging mechanisms.
The São Paulo School of Advanced Science in Obesity will provide graduate students and early career researchers with a two-week training program on obesity research and prevention. The school will feature renowned keynote speakers and cover topics such as epidemiological aspects, genetic nutrition, epigenetics, and emerging preventive ...
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Researchers discovered Setd8 enzyme preserves retinal progenitor cell flexibility, enabling potential regenerative vision therapies. The study highlights a potential target for repairing damaged retinas, with implications for regenerative medicine and ophthalmology.
Researchers found that regulatory features of homoeologous genes become increasingly similar after polyploidization, reducing expression divergence between duplicated gene pairs. Epigenomic convergence directly contributes to transcriptional balance, while genomic structure and cis-regulatory evolution jointly buffer subgenomic conflict.
Researchers identified nine piRNAs linked to longevity, which could be detected through simple blood tests. The study suggests that these molecules may help predict survival and guide therapeutic targets for older adults.
A study by NYU School of Global Public Health found that anxiety about aging contributes to accelerated epigenetic aging, with greater concern about declining health having the strongest association. This can lead to physical decline and increased risk of age-related diseases.
Researchers at Monash University have discovered a way to permanently switch off cancer-causing genes, potentially leading to shorter treatment periods and reduced side effects. The breakthrough uses epigenetic therapy, targeting specific proteins that keep cancer-promoting genes switched on.
A study led by researchers from the Germans Trias i Pujol Research Institute has identified PARG as a new target to enhance chemotherapy in colorectal cancer. Inhibition of PARG significantly increases the cytotoxic effect of chemotherapy, leading to enhanced cell death and apoptosis in different colorectal cancer models.
A new study found that shingles vaccination is associated with lower inflammation, slower epigenetic aging, and overall slower biological aging in older adults. Vaccination showed benefits even four years after the initial dose.
The German Research Foundation (DFG) has funded a three-year project to investigate epigenetic memory in nerve cells. The goal is to understand how gene expressions are preserved via epigenetic regulation, which plays a key role in learning ability, memory function, and healthy brain development.
Researchers have created a comprehensive map of the DNA sequences that control gene expression in human cells, identifying 2.37 million potential regulatory elements. This registry reveals previously unrecognized classes of elements and illuminates how noncoding genetic variation contributes to cell type-specific traits.
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
A research team at The University of Osaka has identified a parallel pathway involving CENP-C for centromere specification and function. This process is vital for ensuring chromosomes are structured and genes are expressed appropriately.
A narrative review reveals that disaster-related prenatal maternal stress can lead to epigenetic modifications in offspring, affecting child health outcomes. Epigenetic markers show promise for shaping interventions to mitigate the effects of stress on health outcomes.
The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
Researchers discovered that high levels of protein BATF2 drive tumor immune suppression in head and neck cancer. Glutamine in the tumor microenvironment silences BATF2, affecting the STING signaling pathway and overall immune response.
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
A new study introduced epigenetic clocks in skeletal muscle from an Asian population, identifying DNA methylation sites associated with age and developing accurate age prediction models using NGS and SBE. The findings offer a reliable method for estimating age and its potential applications in forensic science.
Research found that older women with younger biological ages were more likely to experience increased depressive symptoms during the pandemic. The study suggests that this may be due to reduced social connections and daily routines, which can affect mental health.
Chromatin accessibility maps reveal that MDS stem cells gradually lose their normal identity and acquire characteristics typical of myeloid progenitors. A 'progenitor score' developed by the team tracks cell movement toward a progenitor-like state, correlating with disease severity and prognosis.
Dr. Eric J. Nestler's research has fundamentally reshaped global understanding of addiction and depression by focusing on resilience rather than pathology. His laboratory identified distinct molecular, cellular, and circuit changes in resilient brains that maintain normal behavioral function despite exposure to drugs or stress.
Researchers at Pitt and UPMC Children's Hospital discovered a biomarker of complicated pediatric traumatic brain injury, which may serve as dynamic indicators of post-injury recovery. The study found that children with TBI had a different epigenetic profile compared to those with orthopaedic injuries.
Researchers identified a molecular mechanism linking early-life environments with memory by activating AP-1, which regulates genes involved in neuronal plasticity and learning. Early-life experiences produce long-lasting modulation of AP-1 activity, boosting gene networks that strengthen neuronal connections.
Cancer researchers at Cold Spring Harbor Laboratory have identified key proteins that determine the behavior of two hard-to-treat carcinomas, pancreatic cancer and tuft cell lung cancer. These findings could lead to new therapies targeting specific vulnerabilities in these cancers.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
Researchers identified distinct epigenetic signatures in cord blood linked to increased schizophrenia and other neurodevelopmental conditions. Newborns with higher genetic susceptibility showed differences in DNA methylation patterns, especially in immune-related regions.
Researchers at Gladstone Institutes and UCSF have identified the genetic switches that regulate FOXP3 levels in human and mouse cells. In humans, multiple enhancers work together to keep FOXP3 active, while a repressor keeps it off in conventional T cells. This discovery has important implications for developing immune therapies.
A novel methylation analysis method, called UMBS-seq, achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection. The method outperforms existing methods for 5-methylcytosine detection with low input DNA, preserving DNA integrity.
PRMT5 promotes proliferation, metastasis, therapy resistance, and an immunosuppressive tumor microenvironment in various solid malignancies. Targeting PRMT5 with inhibitors has shown promising therapeutic effects in several cancers.
A new study found that maternal type 1 diabetes is associated with specific epigenetic marks in the child, which affect immune function and expression of genes involved in autoimmune diseases. These changes appear to protect against islet autoimmunity, a precursor to type 1 diabetes.
Microbial metabolites from the gut microbiome influence gene expression, cellular function, and host health. The MDME axis proposes a unified theoretical framework explaining this complex dialogue.
A new gene editing technique, P3a mutagenesis, achieves near 100% success in creating precise DNA mutations. This method simplifies protein engineering, accelerating biomedical research and reducing costs.