Articles tagged with Epistasis
This study uses multi-trait GWAS and genetic networks to dissect the genetic basis of 18 agronomic traits in maize. The analysis identified pleiotropic regulatory genes and revealed interconnected co-regulatory networks, providing strategic targets for simultaneous trait improvement.
Researchers at Cold Spring Harbor Laboratory have discovered that cryptic mutations in tomato genes can increase or decrease the number of reproductive branches on plants. This finding has implications for agriculture and medicine, potentially leading to better crops and more effective medicines.
Researchers developed a new mathematical framework to analyze genetic interactions and identified key regulators in entire biological networks. The approach, which combines geometry and statistics, reveals how individual genes and species influence network dynamics.
Researchers have successfully bred flame-resistant cotton lines by interbreeding white cotton lines. The new cultivar's fabric exhibits natural flame resistance due to synergistic epistasis, a complex interaction between multiple genetic factors.
Researchers at Scripps Research Institute found that influenza viruses handicapped by a single mutation can overcome their disadvantage when combined with other mutations. This phenomenon, known as epistasis, could lead to better development of flu vaccines and therapies.
Charlotte Miton and Zach Schaefer have won the Protein Society's Year 2016 Best Paper award for their research on mutational epistasis and protein structure. Their study reveals that epistasis plays a major role in constraining evolutionary trajectories, with half of fixed mutations becoming positive at later rounds of evolution.