Articles tagged with Heterochromatin
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Cells employ a protein network to repress TE activity and keep themselves healthy. O-GlcNAc transferase (OGT) is a lead choreographer in this process, protecting cells from genomic instability by restraining TET activity.
Scientists have discovered how a mutated ASXL1 gene disrupts normal blood cell development, leading to diseases such as clonal hematopoiesis and malignant leukemias. The study reveals that mutated ASXL1 causes heterochromatin dysfunction, silencing genes essential for blood cell maturation.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
Dr. Jeetain Mittal's NIH grant will support multiscale computational models investigating phase separation in biology, particularly heterochromatin formation and its role in neurodegenerative diseases. The research aims to elucidate the molecular origins of phase separation using innovative models and methods.
Researchers have developed a new method to study the inner workings of cell nuclei during embryonic stem cell differentiation. By using fluorescent proteins, they found that biomaterials become more uniformly distributed as cells mature, resembling oil droplets in water, but with intriguing complexities.
The editorial discusses epigenetic mechanisms leading to oocyte quality loss, a significant factor in age-related fertility decline. Researchers highlight the importance of understanding this process to address the growing issue of advanced maternal age and its impact on reproduction.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
Researchers identified the molecular mechanism underlying Weiss-Kruszka syndrome, a rare neurodevelopmental disorder characterized by craniofacial anomalies and autistic features. The study reveals that the ZFP462 gene mutation leads to a failure to safeguard neural lineage specification during early embryonic development.
A research team led by Ivano Amelio found that the protein p53 acts as a key to maintaining genomic stability, preventing cancer-promoting mutations. Without p53, cells become more aggressive and prone to acquire genomic instability.
Scientists have identified long interspersed nuclear element-1 (L1) RNA as a promising new target for treating progeroid syndromes. Increased L1 RNA expression in cells from patients with these disorders led to deactivation of an enzyme, causing cell aging.
Researchers at IMBA found that Kipferl helps distribute Rhino to piRNA clusters, avoiding sequestration to Satellite arrays. This control mechanism ensures the effective silencing of jumping genes and maintains genome stability.
Researchers propose a new paradigm for analyzing genetic mutations that may lead to cancer after finding varying levels of heterochromatin, a key player in genomic stability. The study reveals that heterochromatin is dynamic and not stable, increasing the rate of mutation.
The new reference genome provides a more complete sequence of the human genome, shedding light on long-running mysteries surrounding centromeres and heterochromatin. This breakthrough enables researchers to better understand gene expression, variation, and epigenetic mechanisms.
A new protein, UAD-2, has been identified as essential for the genesis of piRNAs in Caenorhabditis elegans. The protein and its associated complex colocalize with histone marks in the nucleus.
Researchers have identified the SFiNX complex as a key player in silencing transposons through a DNA-RNA crosstalk mechanism. This interaction enables other domains within the complex or co-recruited silencing effectors to establish heterochromatin, leading to gene expression regulation.
Researchers have discovered that TALEN is up to five times more efficient than CRISPR-Cas9 in targeting densely packed DNA regions, including those causing fragile X syndrome and sickle cell anemia. This breakthrough adds to the need for a broader selection of genome-editing tools to target all parts of the genome.
Researchers discovered a mechanism where histone variant H3.3 is replenished to silence transposons in pluripotent stem cells, potentially linked to cancer tumorigenesis
Researchers have made new discoveries about the disruption of condensates in Rett syndrome, a neurodevelopmental disorder. The study found that MeCP2's condensate-forming ability is disrupted in Rett syndrome and suggests that therapies targeting condensates associated with the protein may be promising.
Researchers discover a way to 'tune down' heterochromatin in early embryos, improving artificial cell reprogramming efficiency. This knowledge can lead to the efficient generation of high-quality stem cells for regenerative medicine approaches.
A study by the Dresden research team discovered the essential role of the SETDB1 protein in regulating heterochromatin formation and preventing inflammation in the intestinal epithelium. The findings suggest that mutations in this gene may contribute to intestinal inflammation in humans, particularly in inflammatory bowel diseases.
Researchers found that linker histone H1 undergoes liquid-liquid phase separation in the nucleus, forming droplets with densely packed DNA and enriching with protein HP1α. This process segregates heterochromatin from euchromatin, revealing a new function of histones in gene regulation.
Researchers dispute the long-held belief that heterochromatin is a reliable guardian of the human genome. A study by University of Arizona researcher Keith Maggert reveals that heterochromatin can flicker on and off, allowing transposons to cause mutations and damage. This instability has significant implications for our understanding ...
Biological experiments confirm that chromatin in mice eyes changes structure over time, allowing for night vision. Mathematical modeling shows nuclear deformation is a crucial point in DNA's structure change.
Researchers reveal how TET proteins convert 5mC to 5hmC, preventing genomic instability and cancer. Defects in TET function are linked to increased levels of DNA damage and genome instability, highlighting the importance of maintaining a balance between DNA methylation and demethylation.
Researchers at Hokkaido University have discovered how a protein called Epe1 maintains a balance between tightly packed and variable DNA structures in yeast cells. This finding could lead to new strategies for suppressing the formation of tumor cells resistant to anti-cancer drugs.
Eukaryotic chromosomes are separated into active euchromatin and inactive heterochromatin by interactions between the two chromatin types. The researchers discovered that heterochromatin core serves as a microlens condensing light in nocturnal retinas.
Researchers at Osaka University found that heterochromatin helps prevent large chromosomal rearrangements by repressing transcription of centromere repeats. The team's study reveals a key mechanism for maintaining chromosomal integrity and could lead to new methods for securing genome stability.
Researchers at USC Dornsife have discovered how the cell's emergency response team, known as paramedics, uses walking molecules to transport damaged DNA to the nucleus for repair. This process is crucial for preventing cancer formation and has implications for human health and genome editing.
Research by Maria A. Blasco and colleagues reveals TERRAs interact with the Polycomb complex to assemble telomeric heterochromatin. In cells deficient for TERRA, telomeres show decreased heterochromatic marks, indicating a crucial role in telomere protection and maintenance.
Scientists from Waseda University and others have successfully visualized the structure of heterochromatin using cryo-electron microscopy. The study sheds light on how heterochromatin regulates genes and its connection to various diseases, including cancer and virus infections.
New research reveals heterochromatin is less dense than previously thought and features a velcro-like protein called HP1 that allows genes to be locked down. The study's findings have implications for understanding higher-order structures like nucleosome strings.
Researchers have elucidated the role of HP1 proteins in relation to chromatin structure and genome stability. The study shows that different HP1 isoforms play distinct roles in regulating chromatin domains.
The proteasome complex has been found to regulate DNA packing in the nucleus, influencing gene expression. In yeast cells, the proteasome can induce heterochromatin formation but prevent its spread, suggesting an alternative mechanism of action beyond proteolysis.
A team of scientists used a novel microscope to measure the density of heterochromatin, a tightly packed form of chromatin found in human cells. The study reveals that heterochromatin DNA is not fully inactive, but rather has physical properties that can be described in live cells.
Researchers reveal histone 1 prevents accumulation of lethal R-loops and genome instability in heterochromatin, contradicting long-held hypothesis.
Researchers found that impaired DNA replication can lead to genome-wide epigenetic changes, resulting in the inheritance of new gene expression states for up to five generations. These epigenetic alterations establish new gene expression patterns that can be passed down through multiple generations.
A study by researchers at Berkeley Lab found that heterochromatin organizes the genome into specific regions of the nucleus using liquid-liquid phase separation. This mechanism allows proteins to be targeted to one 'liquid' or the other based on physical traits, enabling precise gene regulation.
Researchers found that intron sequences promote heterochromatin structure formation, leading to improved chromosome segregation during cell division. This discovery has significant implications for understanding diseases caused by chromosomal abnormalities, such as Down syndrome.
Researchers at UNC School of Medicine discovered that tight DNA packaging in chromosomes mainly guards against virus-like genetic elements known as transposons or 'jumping genes,' which can copy and paste themselves throughout the genome, potentially destroying important genes. The discovery clarifies the role of heterochromatin and ad...
Research found that heterochromatin organisation in embryonic stem cells is maintained in an open form through the action of key stem cell factors. This open architecture may contribute to keeping stem cells unspecialised and full of developmental potential.
Scientists have discovered a new function of the nuclear membrane: repairing catastrophically broken DNA strands. The membrane fixes heterochromatin breaks, preventing chromosome aberrations and potentially fatal cancer formation. This study may reveal how organisms become more predisposed to cancer as they age.
Akinori Awazu's research reveals that active nuclear deformations play a significant role in determining intra-nuclear chromosome architectures. The study suggests that these dynamic changes contribute considerably to the segregation pattern formation of euchromatin and heterochromatin.
Biologists at Brown University found that gene silencing via chromatin in fruit flies declines with age, but administering life span extending measures such as lower calorie diets or increased expression of the protein Sir2 restores the loss of gene silencing due to age. The study suggests a possible line of research to develop more pr...
Researchers at the University of California, San Diego School of Medicine discovered a novel mechanism that suppresses tumor growth by stabilizing heterochromatin, a form of chromosomal DNA. This finding suggests a potential new approach to inhibit cancer gene expression and may represent a new class of tumor suppressors.
Scientists have discovered two structural apparatuses that collaborate to protect repetitive DNA during replication. Disrupting both heterochromatin and replication fork proteins increases abnormal chromosomes and cell death.
Brown University researchers discovered that as cells age, their ability to defend against parasitic strands of genetic material called transposable elements deteriorates. This breakdown allows the newly freed transposons to take full advantage, potentially leading to a decline in cell function and health.
Researchers at Max Planck Institute of Immunobiology and Epigenetics have identified two novel enzymes, Prdm3 and Prdm16, that attach methyl groups to packaging proteins, maintaining heterochromatin structure. Additionally, transcription factors Pax3 and Pax9 are essential for intact heterochromatin, with random binding sites in contra...
Researchers from CSHL and St. Jude's Research Hospital have discovered new details of how a protein complex contributes to heterochromatin assembly and gene silencing in fission yeast. The team identified a previously unknown substructure at the end of Chp1, which plays a crucial role in heterochromatin formation at telomeres.
A recent study by Cold Spring Harbor Laboratory reveals that RNA interference plays a crucial role in regulating chromosomal replication. The findings show that RNAi mechanism causes the enzyme to release its hold on the DNA and allows the replication fork to progress smoothly, protecting cells from DNA damage.
Researchers found a novel system involving Pch2 and Orc1 proteins protecting yeast rDNA from inappropriate meiotic recombination. This protective repeat-associated heterochromatin makes the DNA segments near its boundary particularly vulnerable to recombination.
Researchers have found that stress can be inherited through epigenetic changes, affecting gene expression and potentially influencing diseases like heart disease, diabetes, and schizophrenia. This discovery has implications for the impact of stress on future generations.
Researchers have discovered a mechanism by which stress induces epigenetic changes in Drosophila that can be inherited across generations. The study found that the transcription factor dATF-2 plays a key role in this process, leading to changes in chromatin structure and gene expression.
Researchers at Berkeley Lab have discovered a new process for repairing double-strand breaks in heterochromatin, a crucial step in maintaining genome stability. This mechanism allows cells to accurately repair DNA damage and prevent chromosomal abnormalities that can lead to cancer and birth defects.
Cornell researchers discovered a genetic mechanism in fruit flies that prevents reproduction between two closely related species, Drosophila melanogaster and D. simulans. The mechanism involves rapidly evolving junk DNA in the male's X chromosome, which creates incompatibilities with the female's DNA, leading to embryo death.
A team of scientists has identified a crucial requirement for heterochromatin formation, showing that the strength of Chp1's binding to methylated chromatin is essential. This breakthrough reveals a key mechanism in regulating gene expression and genomic stability.
CSHL researchers have found that changes in small RNA patterns enable transposons to re-activate in continuously dividing cells, leading to genomic instability and potential disease consequences. The team's study implicates RNA interference in epigenetic chromatin changes that occur in immortalized cells.
A team of scientists at Cold Spring Harbor Laboratory solved a puzzle about how genes are expressed by studying the way DNA is packed in yeast. They found that RNA interference plays a crucial role in transmitting epigenetic information across generations, providing specificity to histone modifications.
Researchers used specially modified yeast to study the molecular events necessary for establishing and maintaining centromeric heterochromatin, a specialized DNA structure at the chromosome's centromere. The findings provide insight into how cells ensure each daughter cell receives the correct number of chromosomes.
Researchers have sequenced and analyzed the complex heterochromatin of fruit flies, revealing over 200 protein-coding genes and functional elements. The study sheds light on the critical role of heterochromatin in cellular survival and organization.
The study reveals two molecular pathways controlling the organization of the nucleolus, a critical organelle that manufactures ribosomes, and heterochromatin, which mediates gene silencing. These findings have implications for understanding genome stability and its relation to human disorders like birth defects and cancer.