Articles tagged with Homologous Genes
Researchers discovered that a specific gene duplication in the fungus Madurella fahalii enables it to neutralize medication, leading to effective treatment challenges. This study highlights the potential of molecular techniques to uncover drug resistance mechanisms and pave the way for targeted therapies.
Researchers have uncovered two major genes responsible for sorghum's double-grain spikelet, leading to a significant increase in grain number and crop yield. The study found that the DG1 gene regulates floret meristem formation and differentiation, restoring fertility to the lower floret and resulting in the double-grain trait.
Researchers have discovered a dynamic cross-kingdom horizontal gene transfer between plants and bacteria, transferring 75 genes that enhance carbohydrate metabolism and hormone synthesis. This finding opens up exciting possibilities for biotechnological applications in agriculture.
The study successfully sequenced the genome of purple finger lemon 'YaoJi', identifying key genes linked to rind color variations. The research provides a genomic foundation for further genetic studies and breeding programs, shedding light on the evolutionary history of finger lemons.
This study sequences the chloroplast genome of 'Xinxuan-4', a new pecan cultivar, uncovering genetic stability across the Carya species. The findings reveal gene variations, codon preferences, and SSRs, aiding in understanding evolutionary dynamics and potential breeding strategies.
Researchers have developed a novel tool for the selective and efficient recovery of large DNA molecules using TAR cloning. This technique has been applied to isolate individual gene alleles, study genome architecture and evolution, and engineer synthetic viruses with novel properties, including vaccine development.
The study found that all 86 tridomain homologues of NDP-heptose synthetases are conserved in Actinobacteria, with three types of gene clusters encoding different natural products. The kinase domains of four selected proteins were found to be dysfunctional.
Researchers introduce a new approach to analyzing genome content in animals, resolving long-standing debates about the origin and development of tissues and organ systems. The method yields consistent results with classical views of animal phylogeny, shedding light on early evolutionary history.
Aequatus provides a seamless user experience to visualize homologous genes among species, helping biologists delve into the details of genomic features. The tool supports the Ensembl REST API, improving portability and access to fine-grained information about genes and organisms.
A new testing method developed to accurately detect PMS2 gene mutations has been shown to improve diagnosis and support genetic counseling and medical management for individuals with Lynch syndrome. The approach combines targeted capture next-generation sequencing, multiplex ligation-dependent probe amplification, and long-range PCR fo...
Researchers at New York University identified a checkpoint that is necessary for a genome's viability and normal development during meiosis. Without this restraining mechanism, chromosomes can become irreversibly broken, leading to birth defects such as Down syndrome.
Researchers have pinpointed the first human gene that controls circadian rhythm, a discovery that raises hopes for treating sleep problems in adolescents, the elderly, and shift workers. The study found a mutation in the hPer2 gene, which is responsible for familial advanced sleep-phase syndrome.
Scientists have developed a method to 'knock out' fruit fly genes, allowing researchers to study their functions and identify corresponding human diseases. The technique, also applicable to fixing faulty genes, has the potential to revolutionize gene therapy.
The Drosophila genome sequence has been completed, providing valuable insights into human diseases and animal development. The sequence data reveals homologues for 60% of known genetic flaws causing disease in humans and 70% of genes involved in human cancers.
Researchers found that genes involved in male reproductive processes, such as sperm production and morphology, have evolved at a faster rate than non-sexual genes in humans. This accelerated evolution is attributed to sexual pressure, including competition for mating success and internal sperm competition.
Researchers found a gene, gata5, that can reprogram embryonic cells to become beating heart cells. The discovery suggests using this technique to cultivate and transplant genetically modified heart cells into people with failing hearts.
Researchers at The Jackson Laboratory have identified a chromosomal region that interacts with the tub mutation to prevent deafness in the tubby mouse model. The region, known as moth1, maps to mouse Chromosome 2 and was found to protect C57BL/6J mice from hearing loss.
Scientists map lung cancer gene Pas1 to mouse chromosome 6, shedding light on human lung cancers. The researchers also study the evolution of trichromatic vision in humans and primates, revealing gene duplication events that confer color vision abilities.
Scientists at The Jackson Laboratory have cloned the gene for mouse neuromuscular degeneration, a devastating neurological disease that affects humans such as amyotrophic lateral sclerosis and spinal muscular atrophy. The discovery provides an additional tool for understanding motor neuron death and may lead to new treatments.
Bernard Roizman's research has laid the groundwork for current efforts to develop a vaccine against HSV and gene therapies. He identified essential genes in viral replication, including a protease enzyme targeted by pharmaceutical companies.
A gene defect has been identified as causing a form of hereditary blindness, retinitis pigmentosa. The discovery links the disease to a malfunction of the cytoskeleton, which forms the skeleton of cells and affects internal transport and cell division.
A study in fruit flies reveals a molecular pathway that regulates sensitivity to alcohol, shedding light on why some people are more prone to becoming alcoholics. The researchers hope to find similar genes in humans and link them to alcoholic behaviors.
Scientists discovered 12 novel genes on the Y chromosome that enhance male fertility and are functionally interchangeable with X genes. The study also found that the Y chromosome evolved to preserve housekeeping functions, leading to new insights into Turner syndrome and male infertility.
Researchers at Johns Hopkins Medicine identify TWIST gene as cause of Saethre-Chotzen syndrome, a rare genetic disorder characterized by craniofacial abnormalities and limb defects. The study confirms the role of the TWIST protein in human development and provides insight into the confusion with Crouzon syndrome.