Orthologs

CHOP researchers identify molecules that optimize immune presentation of antigens across the human population

CHOP researchers have identified variants of a chaperone molecule that can enhance the loading of peptides across different HLA types, which could be used in cell therapy and immunization applications. The study found that chicken-derived TAPBPR proteins can react with multiple HLA allotypes and stabilize the empty MHC-I groove, boosti...

Disease-causing protein in cystic fibrosis has ancient roots in sea lamprey

Researchers have identified the oldest known ortholog of the ion channel defective in cystic fibrosis, found in ancient sea lampreys approximately 450 million years ago. The protein diverges significantly from its human counterpart and has unique functional properties, suggesting a distinct evolutionary history.

Evolution: Larger datasets unravel deep roots

Researchers introduce a new approach to analyzing genome content in animals, resolving long-standing debates about the origin and development of tissues and organ systems. The method yields consistent results with classical views of animal phylogeny, shedding light on early evolutionary history.

Resolving the ortholog conjecture

The study confirms that studying genes shared with other animals is a viable means of extrapolating information about human biology. Researchers analyzed 400,000 pairs of genes and found only a weak decrease in functional similarity between orthologs.

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We can learn a lot from other species

Researchers confirmed long-held belief that studying shared genes with other species is useful. They analyzed 400,000 gene pairs and found that studying orthologs is more relevant to understanding human biology than previously thought.