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Scientists deliver new molecule for getting DNA into cells

Researchers at Tokyo Metropolitan University have created a neutral molecule that can carry DNA into biological cells using a process called annealing. This breakthrough promises more effective therapies by reducing inflammation and improving delivery efficiency.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

Subverting plasmids to combat antibiotic resistance

Scientists have developed a new strategy to combat antibiotic resistance by studying the competition among plasmids within bacterial cells. By isolating individual cells and measuring intracellular plasmid competition, researchers discovered basic properties of plasmid and bacteria fitness and evolution.

Capturing 100 years of antibiotic resistance evolution

Researchers have identified a minority of plasmids as the primary cause of multidrug resistance in bacteria, evolving to gain resistance through selective pressure from antibiotics. The study developed a model for plasmid evolution, highlighting pathways and predicting future outbreaks.

Evaluating DNA impurities in recombinant adeno-associated virus

A new study found that recombinant adeno-associated virus (rAAV) capsids contain single-stranded DNA impurities derived from plasmid and host cell DNA. The researchers suggest that the adverse effects of these impurities may differ from those of double-stranded DNA, highlighting the need for further evaluation.

Celestron NexStar 8SE Computerized Telescope

Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

Enterococcus helps E. coli ‘armor up’ in dog, poultry co-infections

A new study finds that Enterococcus faecalis produces protective capsular slime when present with certain strains of pathogenic Escherichia coli, making E. coli more resistant in low-iron environments. This discovery could lead to the development of targeted therapies for specific dog and poultry infections.

A bacterial defense with potential application in genome editing

Researchers discovered a bacterial defense strategy involving two proteins that team up to disable plasmids, which could be applied to gene editing. Guide DNA and a functional protein are key components of this system, showing promise for targeted genome editing.

A hygiene program for chromosomes

A new compartment in mammalian cells, the exclusome, has been discovered to house DNA rings that can be ejected from the nucleus. This process helps protect chromosomes from foreign DNA that could disrupt cellular function. The discovery sheds light on a potential link between the exclusome and autoimmune diseases.

Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered

Researchers have discovered a new plasmid in epidemic Vibrio cholerae samples that introduces genes encoding resistance to multiple antibiotics. The finding underscores the importance of genomic surveillance and suggests that the strain's stability poses a concerning factor for future outbreaks.

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

A novel COVID-19 vaccine using modified bacterial DNA

Researchers have developed a novel COVID-19 vaccine based on altered plasmid DNA that effectively blocks cell infection across all tested variants. The vaccine targets a specific vulnerability in the SARS-CoV-2 virus's spike protein, inducing a focused antibody response.

GQ GMC-500Plus Geiger Counter

GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.

CABBI team develops automated platform for plasmid production

Researchers at University of Illinois at Urbana-Champaign have developed PlasmidMaker, an automated platform for designing and constructing plasmids. The platform uses Pyrococcus furiosus Argonaute-based artificial restriction enzymes to assemble DNA fragments with greater flexibility and precision.

Tiny jumping genes fingered as culprit in rise of antibiotic resistance

Biomedical engineers at Duke University have discovered a physical mechanism that causes high doses of antibiotics to promote the spread of antibiotic resistance between bacteria. The culprit is an overabundance of 'jumping genes,' called transposons, which carry genetic instructions for resistance from cell's source code to plasmids.

Danish researchers discover new hiding place for antibiotic resistance

Researchers at the University of Copenhagen have discovered that resistant bacteria can hide resistance genes in inactive bacteria within biofilms, creating a reservoir of resistance that can be drawn upon when antibiotics are not present. This new understanding challenges the long-held assumption that resistant bacteria lose their res...

DNA-based material with tunable properties

Researchers have created DNA-based materials with tunable properties, which can be controlled by adjusting the level of supercoiling. These materials have potential applications in drug delivery and tissue regeneration.

CalDigit TS4 Thunderbolt 4 Dock

CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

A weapon to make a superbug to become more deadly

A new strain of Klebsiella pneumoniae was discovered in 2017 and found to be resistant to carbapenem antibiotics. A recent study identified an easily transmitted DNA piece that can make this superbug even more deadly and hyper-virulent, posing a significant threat to human health.

Genomic study of 412 anthrax strains provides new virulence clues

Researchers analyzed over 400 anthrax strains and found that human and animal samples tend to have more virulent plasmids than environmental sources. The study suggests a correlation between plasmid copy number and virulence, offering new insights into the severity of specific anthrax strains.

Aranet4 Home CO2 Monitor

Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.

Penn State DNA ladders: Inexpensive molecular rulers for DNA research

Researchers at Penn State have created inexpensive molecular rulers for DNA research using new, license-free DNA ladders. These plasmids can estimate DNA fragment sizes between 50 and 5,000 base pairs in length, offering a cost-effective alternative to commercially available methods.

Finding Zika one paper disc at a time

Researchers at the Wyss Institute for Biologically Inspired Engineering have developed a novel, inexpensive method for detecting the Zika virus that could help slow its spread. The system uses a simple modular workflow comprising three steps: amplification, detection, and strain identification.

DNA may survive suborbital spaceflight, re-entry

Researchers found that plasmid DNA attached to a rocket exterior survived suborbital spaceflight, re-entry, and landing conditions. The study showed that up to 53% of the DNA retained its full biological function, with 35% remaining functional after heating up to 1000°C.

Apple MacBook Pro 14-inch (M4 Pro)

Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.

Overexpression of cytoglobin gene increases neuronal hypoxic tolerance

Researchers from China Medical University discovered that overexpressing the cytoglobin gene in SH-SY5Y cells enhances their resistance to cobalt chloride-induced hypoxia. This breakthrough finding has significant implications for developing gene therapy treatments for hypoxic-ischemic neurological diseases.

GEN reports on advances in DNA vaccine delivery and production

Scientists have made significant progress in developing effective delivery systems and efficient biomanufacturing strategies for DNA vaccines. Novel methodologies have emerged, including transdermal patches, electroporation, and plasmid purification techniques.

Viral replicase points to potential cancer therapy

Researchers have developed an artificial plasmid coding for Sindbis virus replicase genes that causes regression of lung and melanoma tumors in mice. The plasmid forces cells to produce double-stranded RNA, leading to cell death and activation of immune responses.

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

Bioclocks work by controlling chromosome coiling

Researchers found that biological clocks influence gene activity by controlling chromosome coiling in cyanobacteria, suggesting a universal theme for higher organisms. The study provides direct evidence of the regulatory mechanism, which could explain why some genes are active during the day and night.

Naked DNA Rejuvenates Rheumatoid Rodents

Scientists have developed a stripped-down gene therapy approach using naked DNA to treat rheumatoid arthritis in rats. The treatment, which injected TGF-ß plasmids into muscle tissue, significantly reduced chronic arthritis symptoms and joint inflammation.

Apple Watch Series 11 (GPS, 46mm)

Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.