Add BrightSurf on Google Email

Tinkering with the “clockwork” mechanisms of life

Researchers at Université de Montréal successfully recreated two distinct mechanisms that can program the activation and deactivation rates of nanomachines in living organisms across multiple timescales. This breakthrough suggests how engineers can exploit natural processes to improve nanomedicine and other technologies.

SourceUniversity of Montreal·JournalJournal of the American Chemical Society·DateDec 19, 2024

Researchers uncover NSMF protein’s role in relieving DNA replication stress

Researchers discovered NSMF protein's role in alleviating DNA replication stress by displacing weakly bound RPA proteins and promoting phosphorylation. This mechanism accelerates relief of replication stress, offering a new direction for treating various diseases, including cancer and age-related conditions.

Dual action: RNA binding protein also binds DNA and acts as a damage sensor across the genome

Researchers at MUSC have discovered that hnRNP E1, a tumor suppressor protein, not only binds RNA but also DNA to maintain genome integrity and sense or prevent DNA damage. The protein's binding is sequence- and structure-specific, suggesting its potential role in preventing cancer metastasis.

SourceMedical University of South Carolina·JournalLife Science Alliance·TypeExperimental study·DateSep 23, 2021