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Tinkering with the “clockwork” mechanisms of life

Researchers at Université de Montréal successfully recreated two distinct mechanisms that can program the activation and deactivation rates of nanomachines in living organisms across multiple timescales. This breakthrough suggests how engineers can exploit natural processes to improve nanomedicine and other technologies.

SourceUniversity of Montreal·JournalJournal of the American Chemical Society·DateDec 19, 2024

Free-forming organelles help plants adapt to climate change

Researchers have determined the molecular level function of free-forming structures in plant cells that help sense light and temperature, enabling plants to distinguish a range of different light intensities. The formation of these organelles is not random but is linked to specific locations within the cell, particularly near centromeres.

SourceUniversity of California - Riverside·JournalNature Communications·DateMay 7, 2024

Researchers improve blood tests’ ability to detect and monitor cancer

A team of researchers from MIT and the Broad Institute developed two types of injectable molecules called 'priming agents' that can boost DNA levels in blood samples, allowing for earlier cancer diagnosis and more sensitive detection of tumor mutations. The approach could also help improve detection of cancer recurrence.

SourceMassachusetts Institute of Technology·JournalScience·DateJan 18, 2024
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Researchers uncover NSMF protein’s role in relieving DNA replication stress

Researchers discovered NSMF protein's role in alleviating DNA replication stress by displacing weakly bound RPA proteins and promoting phosphorylation. This mechanism accelerates relief of replication stress, offering a new direction for treating various diseases, including cancer and age-related conditions.

SourceUlsan National Institute of Science and Technology(UNIST)·JournalNucleic Acids Research·DateSep 12, 2023

How to program DNA robots to poke and prod cell membranes

Researchers at UNSW and University of Sydney develop DNA 'nanostructures' to effectively manipulate synthetic liposomes, leading to potential applications in biosensing and mRNA vaccines. The study also explores the creation of 'mini biological computers' that can sense their environment and respond to signals.

SourceUniversity of New South Wales·JournalNucleic Acids Research·TypeExperimental study·DateOct 15, 2021

Dual action: RNA binding protein also binds DNA and acts as a damage sensor across the genome

Researchers at MUSC have discovered that hnRNP E1, a tumor suppressor protein, not only binds RNA but also DNA to maintain genome integrity and sense or prevent DNA damage. The protein's binding is sequence- and structure-specific, suggesting its potential role in preventing cancer metastasis.

SourceMedical University of South Carolina·JournalLife Science Alliance·TypeExperimental study·DateSep 23, 2021

DNA 'origami' takes flight in emerging field of nano machines

Researchers are using DNA to build nanoscale devices that can generate, transmit, and sense mechanical forces. These devices have potential uses in drug delivery, nano computers, and nano robots, and could lead to breakthroughs in biomedical research and materials science.

SourceEmory Health Sciences·JournalScience·DateSep 18, 2019

Rockefeller University's Titia de Lange receives NIH Pioneer Award

Titia de Lange, a renowned scientist at Rockefeller University, has been awarded the NIH Pioneer Award for her groundbreaking research on DNA damage response. Her work aims to understand how cells sense and repair damaged DNA, with potential implications for tumorigenesis, aging, and hereditary disorders.

SourceRockefeller University·DateSep 29, 2005
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