Articles tagged with Shotgun Sequencing
A new study reveals that ancient bacterial genomes from teeth of human remains found at four hunter-gatherer cemeteries in East Siberia reconstructed the earliest forms of plague. The findings suggest that these early strains were highly lethal and carried a unique superantigen, increasing the severity of infection.
J. Craig Venter's pioneering work in expressed sequence tags revolutionized brain-expressed genes identification, while his synthetic cells paved the way for synthetic biology as a working discipline. His legacy has reshaped our understanding of genomes and their functions.
Researchers discover that using filters with larger pore sizes significantly improves the recovery of eukaryotic DNA in seawater samples, allowing for more accurate detection of marine life. This breakthrough could enhance the application of environmental DNA analysis in biomonitoring and conservation efforts.
Researchers found a unique microbial signature in colorectal cancer samples that can accurately distinguish them from other types of cancer. This discovery has the potential to improve diagnosis and treatment outcomes for patients with colorectal cancer.
A new study has mapped the history of infectious diseases across millennia, offering insights into how human-animal interactions transformed our health landscape. The research analyzed ancient DNA from over 1,300 prehistoric individuals, revealing that zoonotic diseases became more widespread around 5,000 years ago.
Researchers found a link between gut microbiota and Parkinson's disease, revealing reduced B vitamins and intestinal barrier issues. Treatment with B vitamins could alleviate PD symptoms and slow disease progression.
A new study uses machine learning models to predict cancer patients' responses to immunotherapy based on their gut microbiome features. The research identifies common gut bacterial taxa associated with responders versus non-responders, providing a potential tool for distinguishing and predicting immunotherapy responders.
A recent study published in Annals of the Rheumatic Diseases reveals a link between systemic lupus erythematosus and an altered gut microbiome. Researchers at Osaka University identified two species of Streptococcus bacteria significantly increased in SLE patients, which can affect the body's functions by altering plasma metabolites. T...
A recent study published in Scientific Reports reveals that shotgun sequencing, a favored method for measuring microbial biodiversity, is not as accurate as once thought. Amplicon sequencing, on the other hand, revealed more than twice the number of phyla and 27% more families in water samples from Brazil's major river floodplain systems.
Researchers at UC San Diego and Genentech have developed a new shotgun protein sequencing method that reduces the time required to sequence an unknown antibody to under 36 hours. This breakthrough technique is faster than traditional methods and can automatically detect post-translational modifications.