A new study from the University of California, Irvine, reveals that many recurrent cancer mutations are not drivers of cancer progression but rather passenger hotspots. The research identified APOBEC3A as a key player in creating these hotspot mutations, which can be targeted for novel cancer therapies.
SourceUniversity of California - Irvine·JournalScience·DateJun 27, 2019
Researchers found that hairpin structures can effectively replicate DNA, leading to faster evolution. This discovery challenges traditional views of DNA replication and provides insight into the origins of life on Earth.
SourceLudwig-Maximilians-Universität München·JournalPhysical Review Letters·DateFeb 16, 2017
Researchers use DNA-based tension probes to measure the mechanical forces at the molecular level, revealing how cells sense and interact with their environment. The study provides a new understanding of cellular mechanics and its significance in various biological processes.
SourceEmory Health Sciences·JournalNature Communications·DateOct 24, 2014
Researchers discovered a stem-loop structure in viral RNA that blocks host cell immune proteins, allowing viruses to evade the immune system. By altering this structure, scientists hope to develop treatments that restore natural virus-fighting capabilities and stop or slow viral infections.
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Researchers describe DNA hairpin folding process in water with atomic resolution, finding competition between fast and slow routes and random exploration of microscopic details. This breakthrough has significant implications for therapeutic strategies based on oligonucleotides and RNA interference treatments.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalAngewandte Chemie·DateSep 21, 2010
A study by researchers at The Children's Hospital of Philadelphia found that genetic predisposition may raise the risk of rare disabling syndrome caused by chromosome rearrangements. Translocations between chromosomes 11 and 22 were found to occur more frequently in healthy individuals than previously thought.
SourceChildren's Hospital of Philadelphia·JournalScience·DateFeb 16, 2006