Articles tagged with Allergic Reactions
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
A study of 88,037 Japanese children found exclusive breastfeeding for 6 months associated with a higher prevalence of food allergy and atopic dermatitis. However, it also showed lower rates of bronchial asthma and allergic rhinoconjunctivitis.
Researchers developed a new allergen-specific IgE test to detect functional antibodies capable of triggering immune responses in food allergies. The improved AlphaCL method overcomes limitations of conventional tests, maintaining strong signal responses even with serum components present.
A large-scale study on Swedish children with asthma found that living with cats did not worsen asthma outcomes. The study of 30,277 children over 24 months showed similar asthma severity and lung function in cat-exposed and non-exposed groups.
Researchers have mapped the molecular mechanism behind allergic reactions and developed tailored antibodies to block life-threatening responses. The findings suggest a new approach to targeting the most important allergens and provide a starting point for developing more precise treatments for severe allergy.
Researchers from Chiba University found that antibody therapeutics with stronger Fcγ receptor binding are more likely to be recognized as foreign and associated with higher anaphylaxis risk. High affinities for Fcγ receptors critical determinants of anaphylaxis, study suggests.
Scientists have identified specific proteins in common food sources like corn, soy, and wheat that signal to the immune system that they are safe to eat. Regulatory T cells, also known as Tregs, play a key role in this process, scanning food for these key proteins and calming the immune system when they find them.
Researchers have identified three new proteins, called epitopes, that help the body determine 'safe' foods, aiding in food tolerance and allergy understanding. The epitopes were found in seed proteins from corn, wheat, and soybean, and interact with regulatory T cells to inform tolerance-or-rejection decisions.
Researchers found that exposure to microbes induces a lasting immune memory in fibroblasts, protecting lungs from allergic reactions for months. This discovery opens up new possibilities for developing preventive strategies for respiratory allergies.
A retrospective review of 91 pediatric patients found no significant difference in reaction severity between children taking inhaled corticosteroids alone and those taking combination therapy. The study suggests continuing asthma controller therapy may be appropriate in many cases.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
Research suggests soil microbial communities are a top predictor of childhood allergic disease rates, with certain assemblages appearing linked to better health outcomes. The study found that specific soil microbes promote health, while others negatively impact disease prevalence.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
SJS and TEN survivors experience life-threatening drug reactions and years of physical, emotional and social consequences long after hospital discharge. Participants reported feeling unsupported and suffering from physical complications and psychological impacts such as anxiety and depression.
A long-term study found that more than 70% of toddlers who received peanut patch treatment could tolerate at least three to four peanut kernels after three years. The treatment continued to show a strong safety record, with no cases of anaphylaxis reported.
Two new studies show that oral immunotherapy and oral food challenges can transform daily life for young patients with food allergies, improving quality of life and reducing anxiety. The treatments have been found to be safe and effective in desensitizing children to common allergens such as peanut, tree nuts, sesame, egg, and milk.
New research reveals that social media videos about alpha-gal syndrome and asthma often contain inaccurate or misleading claims, while physician-made videos receive more likes and comments. Allergists can play a crucial role in sharing science-based information to improve public understanding and mitigate health risks.
Researchers have identified a new genetic marker, HLA-A*34:02, which can predict severe gout drug reactions in US patients when combined with HLA-B*58:01. This discovery could improve the safety of allopurinol for millions by expanding genetic screening.
A systematic review and meta-analysis found that non-coeliac gluten/wheat sensitivity (NCGWS) affects approximately 10.3% of the global population, with distinct variations in prevalence across countries. Symptoms often improve when gluten or wheat is avoided, but diagnosis remains challenging due to unclear disease process.
A study published in Pediatrics found that adoption of early peanut introduction guidelines led to significant reductions in diagnosis of peanut and other IgE-mediated food allergies. The findings suggest a promising impact on public health efforts to disseminate these practices.
A new mRNA vaccine has stopped allergens from causing immune reactions and inflammation in mice, instructing the immune system to respond more appropriately. The vaccine is tailored to encode proteins from different allergens, offering a flexible solution to treat seasonal pollen allergies, food sensitivities, and asthma.
A study suggests that nasal sprays are as effective as injection devices like EpiPens in delivering adrenaline to counter anaphylactic shock. The sprays can reach the bloodstream faster, with similar levels of adrenaline seen in blood plasma, and have a longer shelf life.
Researchers have found that ultraviolet light can quickly inactivate airborne allergens, providing a potential new tool for people with allergies. After just 30 minutes, airborne allergen levels decreased by about 20-25% on average.
Researchers have identified specialized immune cells in the intestine that produce chemical messengers triggering anaphylaxis. Targeting these chemicals, like zileuton, may offer a new approach to preventing food-triggered anaphylaxis.
A study identified eight additional foods frequently involved in food-induced anaphylaxis, including goat's and sheep's milk, buckwheat, and pine nut. The research proposes that these foods be considered for inclusion on the European mandatory labelling of foods list due to their frequency, severity, and potential for hidden exposure.
Blum investigates how the immune system interprets what we eat, exploring mechanisms of oral tolerance and signaling that help our bodies tolerate most foods. Her research could enable new immunotherapy strategies for preventing or treating food allergies.
A Northwestern University study found that Zileuton nearly eliminated life-threatening allergic reactions to food allergens in mice by targeting a previously unknown gene called DPEP1. The discovery could lead to a new, simple pill-based treatment for food allergies.
A team of scientists has discovered molecular changes in children's immune systems that determine their response to oral immunotherapy for peanut allergy. Children who respond well have lower levels of inflammatory messengers, while those who don't show increased activation of certain genes.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
A study of over 1,000 students found a strong association between lactose intolerance and nightmares, suggesting that changing eating habits could alleviate poor sleep. The researchers also discovered that people with food sensitivities were more likely to report negative dreams and poor sleep quality.
A new UVA Health study finds that stocking two twin packs of epinephrine autoinjectors and having campers leave their own at home is the most cost-effective strategy for residential camps. This approach comes with an estimated overall cost of $4.33 per camper.
Thetis cells, a newly discovered class of immune cells, play a crucial role in suppressing inflammatory responses to food and promoting oral tolerance. The discovery opens the door to new therapeutic possibilities for treating food allergies.
Researchers discovered a unique subset of immune cells that recognize certain foods as allergenic, leading to increased inflammation and allergy risk. Urban infants had higher levels of these aggressive Th2 cells, while rural children had more regulatory T cells promoting immune balance.
Researchers have identified early changes in the cheek skin barrier of infants that can predict the onset of eczema, or atopic dermatitis. The study found that these changes occur even before any clinical symptoms appear, and may be linked to maternal and environmental influences.
A new study reveals that a special group of cells in the intestines, called tolerogenic dendritic cells, play a key role in preventing food allergies. These cells help to suppress immune responses to food proteins, enabling them to pass through the body without triggering an allergic reaction.
A recent study published in Cell revealed that a specific intestinal immune cell prevents food allergies by breaking the threshold between friend and foe in the gut. Researchers at WashU Medicine identified this cell as RORγt+ dendritic cells, which maintain tolerance to harmless food allergens, preventing allergic reactions.
A review concludes that exposing preschool-aged children to small amounts of food allergens is safer than avoiding them, reducing the risk of severe reactions. Delaying exposure can prolong unnecessary dietary restrictions and increase anxiety related to food allergies.
A new consensus report on anaphylaxis has been released, providing updated clinical criteria and guidelines for diagnosing and treating the condition. The report includes distinct infant findings to improve management in young children, addressing a significant burden on patients and caregivers worldwide.
Researchers found that omalizumab significantly improved treatment outcomes for multi-food allergy patients compared to oral immunotherapy. A total of 36% of omalizumab recipients could tolerate at least 2 grams of multiple food allergens, while only 19% of oral immunotherapy participants achieved this threshold.
Researchers report that eating increasingly higher doses of peanut butter enabled 100% of children with peanut allergy who initially tolerated half a peanut to consume three tablespoons without an allergic reaction. The therapy could potentially fulfill an unmet need for about half of children with peanut allergy, who already can toler...
A new study led by researchers at Mount Sinai Hospital found that children with high-threshold peanut allergy can be treated with a safe and effective approach, allowing them to tolerate larger doses of peanut butter. The treatment involves gradually increasing doses over 18 months, resulting in sustained unresponsiveness to peanuts fo...
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
Research from RIKEN Center for Integrative Medical Sciences found that infant gut bacteria are associated with food sensitivities and allergies, particularly to eggs. The study suggests that probiotic supplements, such as Bifidobacterium, may help prevent food allergies in at-risk infants.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A McGill University-led study found patterns between triggers and symptoms of anaphylaxis, revealing a strong link between tree nuts and throat tightness. The research also suggests that drinking alcohol may increase the risk of severe reactions to nut allergies.
Researchers at Tokyo University of Science found that kaempferol increases RALDH2 levels in dendritic cells, promoting regulatory T-cell development and reducing inflammation. The study suggests that flavonoids like kaempferol may serve as natural remedies to alleviate allergic symptoms.
A global survey of over 4,700 food allergy patients and families found airline travel to be a significant source of worry and anxiety. The study suggests that reasonable accommodations, such as pre-boarding and allergen-free zones, can reduce stress for travelers with food allergies.
Researchers at the University of Pittsburgh have discovered a molecular pathway involving protein BLIMP1 that generates Th2 cells in response to inhaled house dust mite, driving allergic asthma. The study also found signaling molecules IL2 and IL10 are required for BLIMP1 expression, offering new therapeutic options.
Prolonged exposure to incense smoke can cause headaches, respiratory dysfunction, dermatologic sensitivity, and allergic reactions in individuals with pre-existing conditions like asthma. Switching to electric or aromatic vapors, improved ventilation, and limiting burn time may help mitigate these risks.
Two studies reveal that anaphylaxis management remains unclear, with only 14% of respondents confident in using epinephrine. EMS protocols also vary widely, with outdated definitions and inadequate recommendations for treatment.
A recent review published in Clinical & Experimental Allergy suggests that intravenous adrenaline infusions can prevent fatal anaphylaxis, but adrenaline autoinjectors may have little impact in such deadly cases. Fatal anaphylaxis is rare, with a population incidence of 0.03–0.51 per million per year.
A study of over 1,329 adults and 1,907 caregivers found that two-thirds of adults with food allergies and three-quarters of adult caregivers reported psychological distress related to food allergy. The biggest barrier to access to psychological help was cost, highlighting the need for free or low-cost support.
A new study published in Frontiers in Immunology reveals that certain food proteins like milk and meat can help keep gut tumors from growing by triggering the intestinal immune system. This discovery has potential clinical implications for patients with gastrointestinal conditions.
Research from Edith Cowan University highlights the need for accurate testing to prevent antibiotic allergies in children. Most suspected antibiotic allergies are inaccurate, with symptoms often caused by underlying illness. Testing once the child is well enough can help identify true allergies and ensure timely treatment.
Researchers have identified a specific immune cell type and signaling pathway that leads to itching in people with allergies. By targeting this pathway, they hope to develop novel therapeutics for preventing allergic responses and sensitization.
Researchers at UBC have identified a specific cascade of events that lead to allergies and asthma after early-life antibiotic use. The study found that butyrate-producing bacteria play a key role in halting the allergic response, and that targeting ILC2 cells may provide new treatment options.
The new consensus guidance outlines what NHS services need to offer Palforzia desensitization treatment at scale, regardless of patient location or background. The recommendations aim to equitably provide an actual treatment for peanut allergy, moving beyond avoidance and education.
A study by Chiba University researchers reveals that a specific variant of the HLA gene can trigger an endoplasmic reticulum stress response in skin cells when exposed to certain drugs, leading to drug eruptions. This newfound knowledge may form the basis for innovative treatment options.
Australian researchers have identified biomarkers that can predict which children are likely to outgrow their peanut allergy. The study found that two-thirds of children with a peanut allergy remain allergic by age 10, but most who naturally outgrew their allergy did so by age six.
Researchers at Mass General Brigham have identified Th2-multipotent progenitor (Th2-MPP) cells, which may play a crucial role in sustaining type 2 inflammation and contribute to disease symptoms. These findings provide potential targets for therapeutic interventions and lay the groundwork for future disease-modifying approaches.