Articles tagged with Adenoviruses
Researchers have identified a molecular trigger for rare blood clotting conditions after COVID19 adenovirus-based vaccines or natural adenovirus infections. The exact cause is now understood, allowing vaccine developers to adjust the adenovirus protein and prevent this extremely rare reaction.
Researchers from The University of Osaka developed a new technique using mass photometry to detect and quantify components of rAAV particles. This method can distinguish between full and empty particles, streamlining gene therapy manufacturing and improving clinical effectiveness.
A new study has found that 90-95% of participants produced strong T-cell responses after exposure to adenoviral vaccines in a lab setting. This unexpected finding may have implications for the effectiveness and safety of future COVID-19 vaccines, as well as other infectious diseases.
The Organoid group at the Hubrecht Institute produced the first organoid model of the human conjunctiva, which functions like real human conjunctiva. The researchers discovered a new cell type called tuft cells that become more abundant under allergy-like conditions and play a role in eye's reaction to allergies.
Researchers have discovered a link between adenovirus infection and an anti-platelet factor 4 disorder, which can cause severe thrombocytopenia. The condition is rare and potentially fatal, and has been reported in patients with viral symptoms and no exposure to heparin or vaccines.
Researchers link acute severe hepatitis in children to co-infections with multiple common viruses, including AAV2. The study suggests that getting more than one infection may have made children vulnerable to severe hepatitis.
A new study reveals the sophisticated mechanism by which adenoviruses infect human cells and transfer foreign DNA into their nucleus. Protein V plays a crucial role in increasing the virus particle's stability and preventing premature DNA release, which triggers an anti-viral alarm system.
A new DNA sensor can detect both the presence and infectivity of viruses in minutes, providing a significant improvement over current methods that only detect genetic material. This breakthrough could aid in tracking and containing viral outbreaks, as well as understanding mechanisms of infection.
Researchers at Umeå University have made a significant discovery about the diarrhea virus, revealing its ability to survive acidic stomach environments and infect intestines. This understanding could lead to the development of new vaccines, potentially given in edible form, and has implications for tackling diseases like COVID-19.
Researchers at Hokkaido University have developed an adenovirus that specifically replicates in and kills cancer cells using RNA-stabilizing elements. The virus, AdARET, was found to be effective against a range of cancer types, including those without a mutated RAS gene.
A newly discovered protein called Mib1 has been identified as key to successful viral DNA uncoating, enabling adenoviruses to infect cells. The protein's presence is necessary for viral infection, and its inhibition could lead to the development of new anti-viral therapies.
Researchers have discovered a more favorable virus species for delivering genes, as its surface structure avoids liver toxicity. This could enable the use of viruses in gene therapies and vaccine development.
UCSF researchers have discovered a new adenovirus that can spread from primate to primate and potentially from monkeys to humans. The study suggests that adenoviruses may pose a risk for cross-species infections, highlighting the need for vigilance in tracking animal viruses.
Cell biologists from the University of Zurich have identified the infection mechanism for type-5 adenoviruses, revealing that viruses use scavenger cells to trigger an immune response and expose shielded receptors on lung epithelial cells. This discovery has implications for both gene therapy and cancer treatment.
A recent study by The Wistar Institute found that the newly identified human adenovirus AdHu26 commonly infects people, particularly those in Sub-Saharan Africa, rendering it an unlikely candidate as a vaccine carrier. In contrast, chimpanzee adenoviruses demonstrate similar functionality and are considered superior for mass vaccination.
Researchers have developed a gene delivery approach to target therapeutic genes to nerves in the dorsal root ganglion (DRG), a region affected in various sensory neuronopathies. This method, using helper-dependent adenoviruses, was found to be more efficient at delivering genes to DRG nerves compared to nontargeted versions.
A rapid molecular typing strategy can identify adenovirus types in two days, aiding in the selection of antiviral treatment and controlling outbreaks. The strategy's speed will help public health officials better understand adenovirus epidemiology.
Researchers discover RELM-beta's role in IBD, finding it activates macrophages to produce pro-inflammatory factors. Additionally, antibodies against BP180 cause blister formation in mice by activating the classical complement pathway.
A new study by Leah D. Whigham and colleagues found that the human adenovirus Ad-37 causes obesity in chickens, while other viruses like Ad-36 and Ad-5 have been linked to human obesity. More research is needed to determine if these viruses contribute to human obesity.
A new triple-vaccine strategy has been shown to stimulate a strong HIV-specific immune response in monkeys, demonstrating its potential as an improved method of protection against the virus. The approach uses a series of three vaccines that build on each other to generate a stronger immune response than might otherwise be possible.