Articles tagged with Quorum Sensing
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Researchers mapped the frequencies used by Staphylococcus bacteria to communicate, identifying a signal from another species as potent against MRSA. This alternative technique weakens bacterial ability to coordinate attacks on hosts without killing them.
The study highlights the role of proteins, polysaccharides, water channels, and metal ions in shaping biofilm morphology. Bacterial biofilms adapt to environmental stressors through complex interactions between cells and molecular processes in the extracellular space.
Researchers at Ben-Gurion University of the Negev have developed a new compound, PL-18, which disrupts bacterial quorum sensing and biofilm formation. This compound has shown promise in reducing bacterial virulence and inhibiting iron uptake, suggesting potential applications in combating antibiotic-resistant bacteria.
Researchers discovered that tiny RNA molecules play a decisive role in the complex interaction of attack and defence strategies when bacteria are infected with bacteriophages. The study found that these RNA molecules regulate phage genes as well as host genes, effectively explaining the destruction of bacterial cells.
Researchers find that viruses, like bacteriophages, can eavesdrop on bacterial communication and switch from chill mode to kill mode in response to chemical signals. The study reveals tools that control this strategy and demonstrates its abundance, providing new insights into viral behavior.
Researchers at Penn State discovered that bioluminescent bacteria use a small RNA molecule called Qrr1 to coordinate their behavior and colonize the squid's light organ. This mechanism is likely widespread among bacteria, enabling them to exploit quorum sensing pathways.
Scientists have developed an enzyme that effectively breaks down signaling molecules used by bacteria to produce biofilms. The enzyme, LrsL, has exceptional efficacy in suppressing biofilm formation by Pseudomonas aeruginosa, a bacterium known for causing hospital-acquired infections.
Researchers at Ben-Gurion University of the Negev have discovered that artificial sweeteners can significantly impair bacterial communication. Three out of six tested FDA-approved sweeteners were found to inhibit quorum sensing, a key process for bacteria to communicate with each other.
Researchers discovered a clonal group of S. maltophilia strains with increased biofilm formation and colistin resistance, featuring new virulence factors. The study highlights the role of quorum sensing in pathogenicity and persistence.
Geneticist Bonnie Bassler received the $500,000 Gruber Genetics Prize for her pioneering research on quorum sensing, a process by which bacteria communicate using molecular languages. Her discoveries have expanded our understanding of the microbial world and opened up new approaches to promoting health and preventing disease.
Researchers discovered that the human body uses a receptor to detect bacterial quorum sensing molecules, enabling it to react to differing stages of an infection. This allows the body to save energy by not reacting prematurely and prevents collateral damage caused by the immune system's response.
Researchers develop method to induce bacteria to switch between pathways at different times, optimizing production without human intervention. This approach boosts microbial yields by up to tenfold for two different products.
Researchers have developed a mutant version of the RhlR quorum-sensing receptor, which does not require an autoinducer to function. This discovery provides new insights into cell-cell communication and virulence in Pseudomonas aeruginosa, a globally important pathogen.
Scientists at the University of Groningen have created a light-controlled switch that can be used to inhibit or stimulate bacterial communication. The molecule was tested on Pseudomonas aeruginosa and showed a strong response to light, inducing quorum sensing signals.
Researchers at Princeton University have discovered a virus that can listen in on bacterial conversations and kill diseases like E. coli and cholera. The virus, VP882, uses cross-kingdom communication to take the risk out of its decision-making process.
Researchers found that certain antibiotics can alter the way bacteria divide and interact with each other, leading to increased competence and the spread of antibiotic-resistant genes. Biofilms play a crucial role in this process, allowing cells to secrete higher concentrations of a peptide that triggers quorum sensing.
Researchers at UIC have identified a small molecule that promotes quorum sensing in Streptococci, stabilizing chemical signals between cells. This discovery may lead to new ways to manipulate bacterial activity and suppress virulence, potentially aiding in the fight against antibiotic-resistant infections.
A team of researchers at the University of Montreal Hospital Research Centre has discovered a promising solution to improving treatments for cystic fibrosis. By adding quorum-sensing inhibitors to current drugs, they were able to restore treatment efficacy in cells of cystic fibrosis patients.
A team of researchers found a new quorum-sensing molecule that increases the virulence of P. aeruginosa by activating RhlR independently of C4-HSL. This discovery offers potential for developing novel antimicrobial drugs to treat serious infections caused by this bacterium.
Researchers at Pitt Engineering have created synthetic materials that mimic the behavior of living organisms, enabling self-recognition and self-regulation in devices. The findings were published in PNAS and demonstrate potential applications for mechano-responsive materials with tunable self-awareness.
Researchers at Princeton University have developed a way to control bacterial growth using chemical coatings that communicate with bacteria in their own language. The coatings can inhibit or promote bacterial growth as needed, making them useful for applications such as hospital surfaces and industrial equipment.
A recent study published in Cell Chemical Biology reveals new insights into the molecular pathway that leads to Staphylococcus aureus virulence. Researchers developed nanodiscs to observe AgrC receptor kinase activity and discovered a key regulatory hotspot, providing a starting point for designing molecules to inhibit it.
Researchers are developing potent quorum sensing inhibitors using ligand and structure-based screening to combat antibiotic resistance-induced bacterial virulence. Key findings include the potential of synthetic AHL analogs, farnesol, and furanones as biofilm matrix inhibitors.
A new study shows that cranberry extract successfully interrupts the communication between bacteria associated with problematic infections, reducing their severity. Cranberries' proanthocyanidins (PACs) may help control virulence and spread of potentially dangerous bacterial infections worldwide.
A new study reveals how LuxO, a key response regulator in Vibrio cholerae's quorum-sensing cascade, regulates the pathogenicity of the disease-causing bacterium. The researchers discovered an unusual inhibitory mechanism that permanently switches on LuxO, opening doors for potential therapeutic interventions.
Researchers found that bacterial growth and biofilm formation depend on fluid flow and space shape. Fluid flow can interfere with quorum sensing, affecting disease-causing bacteria behavior.
Peter Greenberg and colleague Bonnie Bassler's work on quorum sensing has far-reaching implications for medicine and agriculture. Hundreds of bacterial species use quorum sensing to control various things, and the researchers aim to develop novel medicines targeting this process.
Researchers have synthesized potent new compounds that effectively interfere with Staphylococcus aureus quorum sensing, a key behavior in the development of disease. The peptides work by blocking chemical receptors and can target all four subtypes of staph, making them a promising new antibiotic strategy.
Researchers at University of Wisconsin-Madison have identified small molecule chemicals that can disrupt quorum sensing in Acinetobacter baumanni, a pathogenic bacterium responsible for deadly hospital-acquired infections. The compounds may potentially be used to limit the virulence of the bacteria and prevent biofilm formation.
Researchers discovered a strategy for disrupting bacteria's ability to communicate and coordinate virulence factor expression through compounds that bound to LuxR type receptors, rendering them inactive. This finding may lead to the development of new antibacterial therapeutics aimed at inhibiting bacterial communication.
Researchers have discovered a class of molecules that can target quorum sensing, a key mechanism used by bacteria to communicate and coordinate their behavior. By blocking this system, scientists hope to develop new drugs that can prevent bacterial infections without promoting resistance.
A team led by Rustem F. Ismagilov demonstrates that the density of bacteria, not their absolute number, drives quorum sensing, a process previously thought to require large groups of cells.
Researchers found that a key factor in quorum sensing is the ratio of bacteria to environment volume, regulating biological functions like bioluminescence and nutrient foraging. This discovery provides insights into fundamental design of quorum sensing systems and enables engineering of synthetic gene circuits.
The study developed three transition state analogs that disrupt quorum sensing in Vibrio cholerae and E. coli 0157:H7, reducing the risk of bacterial resistance. The compounds were tested on 26 successive generations and showed no signs of resistance development.
University of Iowa researchers have successfully wiped out established Staphylococcus aureus biofilms by activating the bacteria's quorum-sensing system. The discovery offers insight into a dispersal mechanism for biofilms and might help identify new therapeutic targets to combat chronic infections.
Researchers at Princeton University have discovered a chemical mechanism used by cholera bacteria to communicate with each other, which can be disrupted to potentially halt the disease's progress.
A new vaccine developed by the Scripps Research Institute could block deadly staph infections by sequestering autoinducers that trigger bacterial virulence. The vaccine works by inducing antibodies that bind and neutralize these molecules, preventing the shift from harmless to virulent bacteria.
Scientists discovered a new strategy for bacterial communication called efficiency sensing, which combines existing theories of quorum sensing and diffusion sensing. This approach takes into account the spatial distribution of bacteria, addressing the limitations of traditional models.
Researchers at Cold Spring Harbor Laboratory have made significant progress in understanding how yeast cells communicate with each other through quorum sensing. This complex process allows yeast to coordinate behaviors such as biofilm formation and antibiotic resistance.
Bacteria require a critical number of individuals, called quorum sensing, to engage in activities like bioluminescence and biofilm formation. Research on Vibrio cholerae and other bacteria aims to develop strategies to prevent disease-causing bacteria from becoming virulent.
Researchers observed Bacillus subtilis bacteria moving through fluid in a coordinated pattern, creating swirls and jets that stir the fluid and may aid bacterial detection. The 'self-concentration' phenomenon has potential applications in biotechnology, particularly in mixing minute quantities of solutions.
Scientists at the University of Maryland Biotechnology Institute have cracked the code on bacterial communication, boosting bio-product yields in fermentation vessels. By understanding how bacteria interact and respond to stress signals, researchers can improve production efficiency and increase product outputs.
A new compound has been discovered that can inhibit the formation of biofilms in bacteria, which are often lethal to patients with compromised immune systems. The compound works by disrupting quorum sensing, a process that allows bacterial cells to communicate and mount an effective attack.