Articles tagged with Retrovirology
Salk Institute researchers have determined the structure of HIV's integrase protein during its newly discovered function, enabling the development of better HIV therapeutics. The study reveals a surprising flexibility in the protein's architecture, which can interact with both DNA and RNA, paving the way for new integrase-targeting drugs.
Researchers found that endogenous retroviruses, naturally present in the human genome, can influence the spread of tau aggregates between cells. This suggests that viral proteins could be potential targets for therapies to stop or slow neurodegeneration.
Researchers at University of Queensland discover koala retrovirus is transmitted from mother to joey through close proximity, highlighting a significant threat to wild koala populations. This finding may lead to re-thinked conservation plans and the use of antiretroviral treatment to prevent transmission.
Professor Masao Matsuoka has been awarded the 2011 Retrovirology Prize for his exceptional work on the HBZ genes in HTLV-1 associated diseases. His research showed that HBZ promotes T cell proliferation and induces lymphomas and inflammations.
Researchers at the IRCM discovered a way to counteract HIV-1's interference with Tetherin, a host protein that prevents viral transmission. The Vpu protein neutralizes Tetherin, allowing HIV-1 to spread and infect cells more easily. This finding could lead to the development of new strategies to combat HIV-1.
Researchers investigating UK samples have found no association between XMRV and chronic fatigue syndrome, contradicting a previous report. The study suggests that CFS may encompass a range of diseases and that further investigations are needed to confirm or rule out an association with XMRV infection.
Researchers from Germany investigated a large study of 589 prostate cancer patients between 2000 and 2006 and found no link between XMRV infection and the disease. Despite previous reports suggesting a potential association, the study detected no evidence for XMRV in German prostate cancer patients.
Researchers have developed a 'shock and kill' technique to target and eliminate latent HIV-1 cells in the body. By combining histone deacetylase inhibitors with oxidative stress, infected cells can be induced to produce toxic compounds leading to their death.
A recent study has mapped the spread of HIV-1 subtype B across Europe, revealing that popular tourist destinations like Greece, Portugal, and Spain are major sources of infection. The research found that viruses can be transmitted through travelers, highlighting the need for targeted prevention efforts beyond national borders.
Dr Ben Berkhout's multi-disciplinary approach to RNA research has provided key insights into HIV-1 replication mechanisms. He was awarded the 2008 M Jeang Retrovirology Prize for his outstanding mid-career contribution to HIV research.
A new mechanism of HTLV-1-induced leukemia involves the reduction of histone protein levels, promoting genomic instability and cell division. This discovery suggests that Tax, a key viral protein, uncouples histone gene expression from cell cycle progression.
Dr. Karen Beemon has made significant contributions to understanding how retroviruses transform cells through aberrant phosphorylation of cellular proteins. She was awarded the 2007 Retrovirology Prize for her work, recognized by the journal's Editorial Board and supported by the Ming K. Jeang Foundation.
Dr. Joe Sodroski, a renowned HIV researcher, received the 2006 Retrovirology Prize for his significant contributions to understanding HIV infection and disease. He made key discoveries about how HIV infects cells and causes disease, including identifying the Rev gene and producing the first X-ray structure of gp120.
Stephen P Goff, a prolific scientist with over 250 publications, was recognized for his outstanding research and mentorship. He developed the Moloney murine leukemia virus as a genetic system and made significant contributions to the development of antitumor drug Gleevec.