Researchers have gained a better understanding of the structures and functions of Andhra gene products, paving the way for custom phages for therapeutic applications. The high-resolution knowledge of the virus structure is crucial for developing targeted treatments against Staphylococcus epidermidis infections.
SourceUniversity of Alabama at Birmingham·JournalScience Advances·TypeExperimental study·DateDec 16, 2022
Researchers used X-ray crystallography to reveal the structure of HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of viral assembly and envelope protein incorporation. The study showed that molecular details at this level can help develop new therapeutic agents inhibiting HIV-1 assembly and virus production.
SourceUniversity of Alabama at Birmingham·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJun 21, 2022
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers designed artificial peptides that can bind to viral proteins, blocking entry into cells and causing viruses to clump together. These 'miniproteins' were found to be thermostable and safe for use in humans, with promising results in lab tests and animal models.
SourceIndian Institute of Science (IISc)·JournalNature Chemical Biology·DateJun 4, 2022
Researchers at Medical University of South Carolina found that blocking the enzyme polymerase reduces the virus's ability to multiply. This discovery exposes an Achilles' heel that could be targeted with a therapeutic. Polymerase is a key tool for DNA replication and repair, making the virus vulnerable to disruption.
SourceMedical University of South Carolina·JournalJournal of Virology·TypeExperimental study·DateMay 16, 2022
A new research project led by Professor Edze Westra aims to uncover the mechanisms of molecular communication in viruses, which coordinate their infections and replicate in infected cells. The team will use a combination of theoretical, experimental, and observational approaches to address key questions about viral communication systems.
Researchers developed artificial Sars-CoV-2 virions to study the spike protein's interaction with host cells and its ability to evade the immune system. By understanding this mechanism, they hope to develop targeted therapies and vaccines.
SourceMax-Planck-Gesellschaft·JournalNature Communications·TypeExperimental study·DateFeb 22, 2022
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A team from the Universities of York and Leeds has identified the way viruses like poliovirus and common cold virus assemble infectious copies of their genetic material. The study's findings could lead to the development of drugs that can block viral infections.
SourceUniversity of York·JournalPLOS Pathogens·DateJan 11, 2021
Scientists have identified the way viruses like poliovirus and common cold virus 'package' their genetic code, allowing them to infect cells. The discovery opens up possibilities for developing drugs or anti-viral agents that can stop such infections.
SourceUniversity of Leeds·JournalPLOS Pathogens·DateJan 8, 2021
A study using cryoEM revealed the structural effect of a human mutation that made us immune to simian immunodeficiency virus (SIV). The mutation disrupted the ability of an SIV protein to bind human proteins, giving humans a grace period of tens to hundreds of thousands of years without the disease. This finding could provide clues for...
SourceUniversity of California - Berkeley·JournalCell Host & Microbe·DateAug 22, 2019
Researchers at Osaka University have developed a novel nanopore-based sensor that can detect individual influenza virions with high accuracy. The sensor uses artificial intelligence to identify distinct physical features of the virus, making it suitable for point-of-care screening without specialized expertise.
SourceOsaka University·JournalScientific Reports·DateNov 21, 2018
Researchers have developed a novel approach to track HIV infection by identifying individual viral particles associated with infection. The new method reveals that uncoating leading to infection occurs early in the cytoplasm, around 30 minutes after cell fusion.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateAug 18, 2017
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new flu vaccine with reduced doses could improve production capacities and increase vaccine availability. The use of whole virion vaccines and aluminium adjuvants may enable significant dose sparing without compromising safety.
SourceWiley·JournalBritish Journal of Clinical Pharmacology·DateApr 5, 2017
Researchers at UMass Medical School have discovered two host cell membrane proteins, SERINC5 and SERINC3, that greatly reduce the virulence of HIV-1 by blocking its ability to infect new cells. This breakthrough offers a promising new anti-retroviral strategy for treating HIV-1 and similar viruses.
SourceUMass Chan Medical School·JournalNature·DateSep 30, 2015
Researchers have obtained the first nanometer-resolved image of individual tobacco mosaic virions using low-energy electron holography, a non-destructive single-particle imaging technique. This breakthrough could lead to improved drug design by providing detailed knowledge of biomolecular structures.
SourceAmerican Institute of Physics·JournalApplied Physics Letters·DateSep 28, 2015
Scientists at the University of Oxford have built a complete model of the outer envelope of an influenza A virion using a coarse-grained molecular dynamics simulation. The simulation reveals various characteristics about the membrane components, including the separation of spike proteins and their interactions with host cells. This res...
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Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Scientists at KU Leuven developed a new technique to study HIV proteins at the level of a single viral particle. This allows for quicker screening of anti-HIV drugs and potential to study other diseases.
Scientists at IMIM and UPF have simulated the release of HIV protease, a protein responsible for the virus's maturation process. This breakthrough could lead to the design of new antiretroviral therapies by understanding how free protease appears during the maturation process.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalProceedings of the National Academy of Sciences·DateDec 4, 2012
Virus researchers discovered that VPS4A plays a key role in the release of HIV particles from infected cells. By labeling the enzyme with Green Fluorescent Protein, they tracked its interaction with nascent virions, revealing complex formation and transient activation before budding.
SourceLudwig-Maximilians-Universität München·JournalNature Cell Biology·DateMar 11, 2011
A new study aims to shut down the viral assembly line of coronaviruses, a process crucial for their replication. The research focuses on the M protein, which forms the outer shell of the virus and is critical for its pathogenesis.
SourceArizona State University·JournalJournal of Virology·DateJan 11, 2011
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Using total internal reflection microscopy, researchers have observed hundreds of thousands of molecules coming together to form a single HIV particle. The technique allows scientists to study the assembly process in real-time and gain insights into viral behavior.
Researchers have developed a new technique to produce infectious human papillomavirus (HPV) in the lab, over 1,000 times faster than existing methods. This breakthrough could lead to new antiviral drugs and enhanced vaccines that target early stages of infection.
SourceHoward Hughes Medical Institute·JournalProceedings of the National Academy of Sciences·DateJun 13, 2005
A team from Pacific Northwest National Laboratory and Oregon Health & Science University has discovered a record number of proteins for the highly infectious human cytomegalovirus, doubling the previously identified amount. The study reveals that HCMV may express as many as 200 proteins at various points in its life cycle.
SourceDOE/Pacific Northwest National Laboratory·JournalJournal of Virology·DateSep 29, 2004
Rao's research aims to understand the mechanism of virus assembly, a crucial step in viral transmission and disease spread. By studying the brome mosaic virus, his lab hopes to develop new strategies for blocking virus assembly and preventing disease.
SourceUniversity of California - Riverside·DateOct 1, 2003
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