Articles tagged with Virions
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have gained a better understanding of the structures and functions of Andhra gene products, paving the way for custom phages for therapeutic applications. The high-resolution knowledge of the virus structure is crucial for developing targeted treatments against Staphylococcus epidermidis infections.
Researchers used X-ray crystallography to reveal the structure of HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of viral assembly and envelope protein incorporation. The study showed that molecular details at this level can help develop new therapeutic agents inhibiting HIV-1 assembly and virus production.
Researchers designed artificial peptides that can bind to viral proteins, blocking entry into cells and causing viruses to clump together. These 'miniproteins' were found to be thermostable and safe for use in humans, with promising results in lab tests and animal models.
Researchers at Medical University of South Carolina found that blocking the enzyme polymerase reduces the virus's ability to multiply. This discovery exposes an Achilles' heel that could be targeted with a therapeutic. Polymerase is a key tool for DNA replication and repair, making the virus vulnerable to disruption.
A new research project led by Professor Edze Westra aims to uncover the mechanisms of molecular communication in viruses, which coordinate their infections and replicate in infected cells. The team will use a combination of theoretical, experimental, and observational approaches to address key questions about viral communication systems.
Researchers developed artificial Sars-CoV-2 virions to study the spike protein's interaction with host cells and its ability to evade the immune system. By understanding this mechanism, they hope to develop targeted therapies and vaccines.
A team from the Universities of York and Leeds has identified the way viruses like poliovirus and common cold virus assemble infectious copies of their genetic material. The study's findings could lead to the development of drugs that can block viral infections.
Scientists have identified the way viruses like poliovirus and common cold virus 'package' their genetic code, allowing them to infect cells. The discovery opens up possibilities for developing drugs or anti-viral agents that can stop such infections.
A study using cryoEM revealed the structural effect of a human mutation that made us immune to simian immunodeficiency virus (SIV). The mutation disrupted the ability of an SIV protein to bind human proteins, giving humans a grace period of tens to hundreds of thousands of years without the disease. This finding could provide clues for...
Researchers at Osaka University have developed a novel nanopore-based sensor that can detect individual influenza virions with high accuracy. The sensor uses artificial intelligence to identify distinct physical features of the virus, making it suitable for point-of-care screening without specialized expertise.
Researchers have developed a novel approach to track HIV infection by identifying individual viral particles associated with infection. The new method reveals that uncoating leading to infection occurs early in the cytoplasm, around 30 minutes after cell fusion.
A new flu vaccine with reduced doses could improve production capacities and increase vaccine availability. The use of whole virion vaccines and aluminium adjuvants may enable significant dose sparing without compromising safety.
Researchers at UMass Medical School have discovered two host cell membrane proteins, SERINC5 and SERINC3, that greatly reduce the virulence of HIV-1 by blocking its ability to infect new cells. This breakthrough offers a promising new anti-retroviral strategy for treating HIV-1 and similar viruses.
Researchers have obtained the first nanometer-resolved image of individual tobacco mosaic virions using low-energy electron holography, a non-destructive single-particle imaging technique. This breakthrough could lead to improved drug design by providing detailed knowledge of biomolecular structures.
Scientists at the University of Oxford have built a complete model of the outer envelope of an influenza A virion using a coarse-grained molecular dynamics simulation. The simulation reveals various characteristics about the membrane components, including the separation of spike proteins and their interactions with host cells. This res...
Scientists at KU Leuven developed a new technique to study HIV proteins at the level of a single viral particle. This allows for quicker screening of anti-HIV drugs and potential to study other diseases.
Scientists at IMIM and UPF have simulated the release of HIV protease, a protein responsible for the virus's maturation process. This breakthrough could lead to the design of new antiretroviral therapies by understanding how free protease appears during the maturation process.
Virus researchers discovered that VPS4A plays a key role in the release of HIV particles from infected cells. By labeling the enzyme with Green Fluorescent Protein, they tracked its interaction with nascent virions, revealing complex formation and transient activation before budding.
A new study aims to shut down the viral assembly line of coronaviruses, a process crucial for their replication. The research focuses on the M protein, which forms the outer shell of the virus and is critical for its pathogenesis.
Using total internal reflection microscopy, researchers have observed hundreds of thousands of molecules coming together to form a single HIV particle. The technique allows scientists to study the assembly process in real-time and gain insights into viral behavior.
Researchers have developed a new technique to produce infectious human papillomavirus (HPV) in the lab, over 1,000 times faster than existing methods. This breakthrough could lead to new antiviral drugs and enhanced vaccines that target early stages of infection.
A team from Pacific Northwest National Laboratory and Oregon Health & Science University has discovered a record number of proteins for the highly infectious human cytomegalovirus, doubling the previously identified amount. The study reveals that HCMV may express as many as 200 proteins at various points in its life cycle.
Rao's research aims to understand the mechanism of virus assembly, a crucial step in viral transmission and disease spread. By studying the brome mosaic virus, his lab hopes to develop new strategies for blocking virus assembly and preventing disease.