Articles tagged with Dna Supercoiling
Researchers at Baylor College of Medicine have discovered how DNA gyrase resolves DNA entanglements, revealing the first step in the mechanism. The study used advanced imaging techniques to visualize the interactions between supercoiled DNA and the enzyme, showing that gyrase is attracted to the looped structure.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
Researchers developed a simple physical model to explain DNA deformations caused by ions and temperature changes. The model reveals that salt-induced twist changes are driven by electrostatic interactions, while temperature-induced changes are related to DNA diameter variation. These findings provide new insights into the molecular mec...
Researchers introduce a new theoretical model that explains how DNA supercoiling drives collective dynamics of RNA polymerases during transcription. The model considers the number of RNAPs and transcription factor binding, revealing two contrasting modes of RNAP group dynamics.
A study by researchers at Baylor College of Medicine reveals that supercoiling and looping in DNA can transmit mechanical stress along the backbone, promoting separation of strands and exposure of DNA bases. This phenomenon, known as 'action at a distance,' suggests a new perspective on how DNA activities are regulated.
Researchers have created DNA-based materials with tunable properties, which can be controlled by adjusting the level of supercoiling. These materials have potential applications in drug delivery and tissue regeneration.
The study reveals that DNA's twisted structure actively regulates genes, particularly those responding to stress and stimuli. Topoisomerase TOP2A eliminates negative supercoiling at gene promoters, allowing for quick activation of these genes.
A recent study published in Cell Reports reveals that DNA supercoiling is involved in regulating gene expression, rather than being just collateral damage. The researchers found that specific genes are massively activated in response to stimuli, and topoisomerase TOP2A plays a crucial role in this process.
Scientists have made new discoveries about transcription, a fundamental process in all living cells. Researchers used advanced imaging techniques to study transcription at the scale of individual genes, revealing unexpected drivers of cellular individuality.
Researchers used molecular dynamics simulations to study DNA supercoiling and its impact on knot formation. They found that supercoiled regions can persistently lock in place critical contact points in DNA knots, making it easier for specialized enzymes to untie them.
A team of scientists found that supercoiling powers the movement of cohesin protein complex along chromatin fibers, a key piece in understanding gene expression regulation. This discovery establishes a new chemo-mechanical process in chromosomes shaping optimal gene regulation through structural arrangements.
Scientists from NCBS and NIH have elucidated the pattern of DNA supercoiling across the genome of E. coli, finding that it varies locally across genes. The study reveals that bacterial cells regulate gene expression by altering the structure of their genomes in response to environmental changes.
Researchers identified protein MCM that changes DNA topology, forming 'supercoils.' This can lead to cancer cells growing out of control. The study provides new insight into MCM's role in gene regulation and cancer.
Researchers used magnetic tweezers to study the action of topoisomerase I enzyme in yeast cells, revealing that topotecan's ability to kill cancer cells comes from forcing DNA into positive supercoils. The accumulation of these supercoils triggers cell suicide.