Single Stranded Rna

A*STAR scientists develop new method to reveal how RNA structure influences health and disease

Study uncovers new drug target for huge class of viruses

A study from UMBC reveals a conserved RNA-protein interaction as a promising target for broad-spectrum enterovirus antivirals. The researchers found that a fusion protein called 3CD recruits proteins to assemble the replication complex, and targeting this interface could lead to universal drugs.

UMass Amherst chemists develop tool providing unrivaled look inside cells

Researchers at UMass Amherst have developed a new tool, iConRNA, that provides an unrivaled look inside cells and can help solve the mystery of how devastating diseases develop. The tool resolves the balance of physical driving forces of phase separation and predicts how this balance is tuned under different cellular situations.

Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2

Researchers at Hokkaido University identified 2-thiouridine as a broad-spectrum antiviral drug candidate targeting ssRNA+ viruses. It inhibits viral replication and increases survival rates in mice models for dengue and COVID-19.

Chinese Medical Journal Review shines a light on the overlooked virus, hepatitis D

Researchers discuss Hepatitis D's life cycle and interactions with its host, exploring strategies for further research to combat this overlooked virus. HDV coinfects people with hepatitis B, rapidly progressing to liver cirrhosis and cancer if left untreated, with a review published in the Chinese Medical Journal.

Computational study reveals how Ebola nucleocapsid stabilizes

A computational study of Ebola's nucleocapsid reveals how ssRNA encapsulation stabilizes the virus, maintaining its structural integrity. The model includes all atoms and ions essential for the helical assembly, providing insights into the virus's ability to infect and replicate.

'Knot' your average nanostructure: Single-stranded molecules that fold into big shapes

Researchers have created large-scale, programmable self-folding DNA and RNA structures using user-friendly software tools. The new nanostructures can be successfully cloned and amplified inside living cells, offering a low-cost high-scale production strategy for manufacturing the nanostructures.