Articles tagged with Amyotrophic Lateral Sclerosis
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A research team has developed a way to produce corticospinal-like neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury. The study uses a multi-component gene-expression system called NVOF to precisely fine tune regulatory signals, resulting in mature neurons with distinct characteristics.
A Texas A&M University study has identified a mouse strain that responds to a viral infection in a way similar to humans with ALS. The researchers found that the initial viral infection triggers lasting damage to the spinal cord and its nerves and muscles, even after the virus is cleared.
A Swedish study published in JAMA Neurology found that prolonged air pollution exposure is associated with a higher risk of developing motor neuron disease, including ALS. Long-term exposure to even low levels of air pollutants was linked to faster disease progression and increased mortality rates.
Tofersen, a new drug approved by the FDA, has been shown to delay disease progression and stabilize symptoms in people with a genetic form of ALS. Long-term use of tofersen slows ALS disease progression and death in about one-quarter of participants, leading to stabilization or improvement in strength and mobility.
In a new study, Northwestern scientists identified a previously unknown toxic sub-species of amyloid beta oligomers that drive brain changes in Alzheimer's disease. NU-9 decreased this toxin and reduced damage in a mouse model, suggesting it could prevent or delay the cascade of toxic events that destroy neurons.
A new rapid blood test for ALS has been developed by Brain Chemistry Labs, providing 97% accuracy in diagnosing the disease from a single blood draw. The test is based on microRNA analysis and can also rule out patients without ALS, offering hope to those struggling with this debilitating condition.
Scientists at Michigan Medicine have developed machine learning models that can analyze blood samples for biomarkers to detect ALS earlier and predict disease severity. The models show promising results, with predictions accurate up to 91% in some cases, and could lead to improved diagnostic accuracy and treatment options.
Researchers will examine protein stability mechanisms in Thermus thermophilus to advance treatments for diseases such as Alzheimer's, ALS, and cancer. The team will explore the structure of Rieske proteins and their role in energy production to understand how to restore stability.
The UT Health San Antonio Center for Brain Health brings together expertise in dozens of disorders, emphasizing education, family support and community connection. The center is part of ongoing national research initiatives, including a study on ALS and HEALEY ALS Platform Trial.
University of Missouri researchers are combining in-home sensor technology with artificial intelligence to monitor daily changes in ALS patients' health. The system uses machine learning to estimate a patient's score on the ALS Functional Rating Scale Revised, predicting potential problems before they occur.
A new method developed by Penn State researchers improves the analysis of genetic data, identifying more genes associated with neurodegenerative diseases like Alzheimer's and ALS. The technique, BASIC, integrates both bulk tissue samples and single-cell data to uncover shared genetic effects across different cell types.
The study examines the global epidemiology of amyotrophic lateral sclerosis (ALS) and other motor neuron diseases (MNDs), revealing a rising global burden with significant variations across regions. Regional factors contribute to these diseases, emphasizing the need for optimized medical resources and further research.
Researchers at Tel Aviv University discovered a molecular mechanism that plays a key role in ALS and were able to neutralize it through gene therapy. The study found that reducing microRNA-126 levels leads to the formation of toxic aggregates of the TDP-43 protein, causing neuron damage.
The comprehensive dataset from Answer ALS is now harmonized with ALS TDI's ARC study data, forming the world's largest open ALS research resource. Researchers can analyze over 150 terabytes of harmonized data to accelerate discoveries and uncover new disease patterns.
A new Northwestern University study reveals how a key disease protein, TDP-43, drives overactive nerve cells in ALS and FTD. The findings highlight a promising new drug that can fix this error and restore balance to neurons.
Researchers found significant overlap in ultrarare genetic variants between ALS and HSP, including newly identified genes contributing to disease risk for both conditions. This study highlights the shared origins of these disorders and may lead to more personalized care for patients.
Researchers found large spinal motor neurons suffer from intrinsic protein and organelle degradation stress. The study suggests reducing this burden as a potential therapeutic strategy for ALS.
The 15th annual Les Turner Symposium on ALS will bring together leading researchers to discuss the latest research and perspectives on the disease. Dr. Don Cleveland, a renowned expert, will deliver a keynote address on developing designer DNA drug therapy for neurodegenerative diseases.
Researchers have developed a non-invasive blood test that can detect Amyotrophic Lateral Sclerosis (ALS) earlier and with higher accuracy by measuring cell-free DNA. The test distinguishes between ALS patients and healthy individuals, as well as those with other neurological conditions.
Researchers at WashU have gained unprecedented views of a protein linked to ALS and FTD, revealing unique shapes that may contribute to disease progression. The discovery opens doors to new approaches for treatment and prevention, with the team planning further experiments to understand the protein's role in health and disease.
Researchers at the University of Kansas found that individuals with ALS can improve their speech rhythm control by speaking more slowly, making it easier for others to understand. The study aims to develop personalized speech therapy strategies for patients with progressive communicative disorders.
Researchers at La Jolla Institute for Immunology discovered that ALS is likely caused by an autoimmune reaction triggered by inflammatory CD4+ T cells targeting specific proteins in the nervous system. Anti-inflammatory CD4+ T cells may slow disease progression and prolong survival times.
Researchers identified 33 plasma proteins that differ significantly in patients with ALS, suggesting the disease could be detected up to 10 years before symptoms appear. Machine learning models showed strong performance in separating ALS cases from non-ALS cases, with an accuracy of over 98.3%.
Researchers discovered that FGF21, a muscle hormone released during exercise, is elevated in people with ALS and may play a protective role. Higher levels of FGF21 were associated with slower disease progression and longer survival in patients.
Researchers found that mutations in the CFAP410 gene change its interaction with another protein, making motor neuron cells more vulnerable to DNA damage and cell death. This discovery provides new insights into the mechanisms underlying Motor Neurone Disease and highlights potential targets for new therapies.
Researchers at Mount Sinai Hospital discovered a unique elemental pattern in single hair strands that distinguishes people with ALS from healthy individuals. This finding suggests a simple, non-invasive hair-based test could speed up ALS diagnosis and improve patient care.
A wearable robot has been upgraded to provide personalized assistance to ALS and stroke patients. The device uses machine learning and a physics-based model to adapt to an individual user's movements, offering more nuanced help with daily tasks.
The initiative aims to uncover critical genetic and metabolic mechanisms that may explain the increased incidence of ALS among high-performing populations. By using remote-participation technology, up to 500 participants will be collected, eliminating logistical barriers and expanding who can take part in research.
A study using stem cells from ALS patients identified a potential new target for treatment: the integrated stress response. The researchers found that blocking this stress response can reverse damage in lab-grown motor neurons, providing a promising proof-of-concept for future therapeutic strategies.
A recent study found that over 90% of ALS patients use smartphones and computers but remain unaware of accessibility tools. These features can greatly enhance their quality of life as the disease progresses.
A new study suggests that marbling of fat inside muscles is a strong indicator of poor health, including obesity, Type 2 diabetes, and neuromuscular disorders. The research found that intramuscular fat acts as a physical barrier obstructing muscle healing and regeneration.
A Tohoku University study reveals that ALS-causing mutations converge on the dysregulation of UNC13A gene expression, which could lead to effective treatment strategies. The researchers identified two molecular mechanisms underlying this reduction, including mRNA destabilization and REST overexpression.
Answer ALS is launching a groundbreaking collaboration with Tulane University and the Pennington Biomedical Research Center to harness AI for ALS treatment discovery. The Louisiana AI Drug Development Infrastructure for ALS (LADDIA) will prioritize therapeutic targets using AI-driven insights from the Answer ALS' Neuromine Data Portal.
The FDA has granted orphan drug designation to a new gene therapy for Amyotrophic Lateral Sclerosis (ALS), a devastating disease with no current effective treatment. The therapy uses a viral vector expressing the secreted isoform of Klotho protein, showing promising results in preclinical studies.
Researchers at Cedars-Sinai created a lifelike model of motor neurons that die in patients with ALS, allowing them to detect differences between healthy and diseased cells. The study suggests that excessive glutamate signaling may be a contributing factor to the disease.
Researchers have created 'spinal cord-like' microtissues from stem cells to study ALS-linked neuroinflammation. These microtissues, derived from ALS patients and healthy donors, exhibit distinct inflammatory responses, enabling the testing of FDA-approved drugs for personalized treatment approaches.
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Researchers at UC Davis developed a brain-computer interface that translates neural activity into speech in real time. The technology allows individuals with ALS to communicate more naturally and inclusively, with 60% of synthesized words intelligible to listeners.
Researchers at Harvard University's Wyss Institute have successfully created human microglia cells in a dish, using induced pluripotent stem cells, within four days. This breakthrough enables new avenues for brain disease-focused research and potential therapeutic perspectives.
Researchers discover abnormal polyadenylation in ALS, affecting mRNA function and potentially leading to new therapeutic targets. The study suggests that correcting gene function through polyadenylation correction could prevent motor neuron dysfunction and death in ALS patients.
Old neurons exhibit unique defects resulting from molecular stress, making them more vulnerable to neurodegeneration. The study sheds light on the molecular mechanisms behind brain cell deterioration, which could lead to new therapies for preventing neurodegenerative diseases.
Researchers at University of Virginia Health System discovered that an immune molecule called STING drives the formation of harmful plaques and protein tangles associated with Alzheimer's. Blocking STING protected lab mice from mental decline, suggesting a promising treatment target for neurodegenerative diseases.
Researchers show that stress granules, previously implicated in neurodegenerative diseases, can actually suppress fibril formation and even reverse the effects of disease-causing mutations. This discovery offers new insights into the development of potential treatments for neurodegenerative diseases.
A novel therapy developed by Columbia University scientist Neil Shneider has shown unprecedented functional recovery in patients with a rare form of ALS caused by a genetic mutation in the FUS gene. After six months of treatment, patients experienced up to an 83% decrease in neurofilament light, a biomarker of nerve damage.
Researchers at Stockholm University and UK DRI have identified a common disease signature across all ALS-causing mutations in motor neurons, revealing early mitochondrial dysfunction. This discovery opens up new avenues for early treatment methods, targeting the energy factories of nerve cells before other signs of disease appear.
Scientists have developed a sugar-coated nanotherapy that effectively traps misfolded proteins, neutralizing their toxic effects on neurons. The treatment significantly boosts the survival of lab-grown human neurons under stress from disease-causing proteins.
A protein link between brain diseases and leaky blood vessels reveals that endothelial cell dysfunction plays a crucial role in the progression of neurodegenerative diseases. The study found that reduced TDP-43 levels lead to gaps in blood vessel walls, allowing toxic molecules to enter the brain.
Researchers at Thomas Jefferson University used computational biology to analyze blood samples from people with and without ALS, discovering different combinations of small non-coding RNAs associated with disease progression and survival times.
A team of researchers from Goethe University and Kiel University has discovered a way to prevent the formation of harmful protein aggregates in cultured cells. The study found that linking TDP-43 with SUMO prevents its aggregation, suggesting a potential new approach for treating ALS and other neurodegenerative diseases.
Researchers found that ATP regulates protein condensation and cytoplasm viscosity, preventing harmful protein aggregates. Boosting ATP production decreases viscosity, dispersing existing and preventing future protein aggregations.
A dual-principal investigator research group led by Dartmouth and the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital will test the effectiveness of video as a communication tool during patient visits for people living with Amyotrophic Lateral Sclerosis (ALS) and their caregivers.
A new Northwestern University study finds that NU-9 improves neuron health in animal models of Alzheimer's disease by addressing the underlying mechanisms of misfolded proteins. The drug reduces protein buildup and prevents inflammation, showing potential for treating neurodegenerative diseases.
A machine-learning algorithm named catGRANULE 2.0 ROBOT identifies molecular targets for further researches and therapies in neurodegenerative diseases. The algorithm analyzes protein-RNA interaction to predict potential harm and identify early pathological signals.
The ALL ALS Consortium has recruited over 300 participants across two studies, ASSESS and PREVENT, aiming to disrupt traditional ALS research by making data and samples available worldwide. The consortium seeks to discover new drug targets and approaches for effective treatments.
Researchers from UConn School of Medicine reveal a novel pathway in cellular dysfunction contributing to neurodegenerative diseases like Alzheimer's and ALS. They discovered that endothelial cells, the inner lining of blood vessels, play a critical role in neurodegeneration by disrupting the blood-brain barrier's protection.
Researchers investigated the effects of electroacupuncture on gut microbiota and metabolomics in ALS patients, finding a reduction in Eisenbergiella abundance and improvements in Lachnospiraceae levels. The study suggests that this treatment may be beneficial for patients with ALS.
Researchers found that p-tau proteins in blood are elevated in both Alzheimer's and ALS patients, making them less specific for Alzheimer's diagnosis. However, they also show promise as potential biomarkers for early detection of ALS or monitoring disease progression.
Scientists repurposed the drug edaravone as an imaging probe to detect oxidative stress in brain tissue using PET scans. This technique can help diagnose neurological conditions such as ALS and Alzheimer's disease earlier, when treatment is more effective.
Dr. Guy Rouleau, a renowned geneticist and neurologist, has founded the world's first academic institution committed to open science principles. The Neuro institute aims to transform how brain disease research is conducted worldwide by promoting data sharing and collaboration.
A new blood test may help identify and monitor Amyotrophic Lateral Sclerosis (ALS), according to a recent study published in Neurology. The test uses neurofilament light chain proteins to accurately diagnose ALS, with an accuracy rate of over 80%.