Articles tagged with Purkinje Cells
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Researchers discovered that Purkinje cells in the cerebellum signal to stop tongue movement as it approaches a target, allowing for precise control of tongue movements. This understanding is crucial for developing treatments for symptoms linked to cerebellar dysfunction, such as vocal muscle spasms and speech disorders.
Scripps Research scientists discovered how microRNAs impact Purkinje cell development, shedding light on the intricate process required to build brain complexity. The team found that microRNAs are critical during two phases in Purkinje cell development, controlling precise timing of different aspects.
Researchers at ISTA investigated the crucial set of synapses between neurons within the cerebellum, uncovering details of their function and development. The study used advanced techniques to look at the inhibitory synapses in great detail, revealing how they delicately influence the cell's signal output.
Researchers have generated comprehensive genetic maps of the developing cerebellum in humans, mice, and opossums. The study reveals ancestral and species-specific cellular characteristics spanning over 160 million years of mammalian evolution.
Researchers found that nearly all Purkinje cells in the human cerebellum have multiple primary dendrites, which contradicts the traditional understanding of a one-to-one relationship between climbing fibers and Purkinje cells. This discovery was made possible by analyzing thousands of cells from both human and mouse tissue using immuno...
Researchers at the University of Houston have developed a protocol to reprogram human heart cells into specialized cells that conduct electricity, enabling rhythmic heartbeat and repair diseased hearts. The discovery could lead to improved cardiac function and new pharmacological therapies for heart diseases.
Researchers uncover abnormalities in neuronal connectivity and synaptic structure in cells lacking sacsin protein, leading to Purkinje cell death. The study expands knowledge of sacsin's functions and suggests a possible link between ARSACS and other brain disorders.
A new study found that microglia regulate neuronal subtypes differently in response to bacteria, affecting intrinsic excitability. Pyramidal cells exhibited lower excitability, while Purkinje cells showed higher excitability when modulated by microglia.
Researchers found a mutation in ELOVL4 enzyme impairs communication between neurons, leading to impaired motor control and coordination. The study provides new insights into the essential role of ELOVL4 in motor function and synaptic plasticity, suggesting potential therapeutic strategies for patients with spinocerebellar ataxia.
A new study by Children's National Hospital explores the neural circuitry of premature birth and its impact on locomotor development. Researchers found that Purkinje cells play a central role in learning deficits caused by complications at birth.
Researchers at Kyoto University discovered that Purkinje cell dendrites can filter and modulate incoming signals, enabling new learning mechanisms in the cerebellum. This finding provides insight into the brain's ability to modify itself and change signaling properties.
Researchers at Max Planck Florida Institute for Neuroscience have revealed a special input pathway that codes sensory information in the Cerebellum. Climbing fibers are found to be responsible for conveying sensory information, with activity mirrored in Purkinje cells.
A study by Children's National Health System researchers found that chronic sublethal hypoxia causes locomotor miscoordination and long-term cerebellar learning deficits. Restoring GABA levels with an off-the-shelf medicine improves Purkinje cell firing and locomotor performance in a model of neonatal brain injury.
Researchers have identified a new role for inhibition in regulating motor learning in the cerebellum, finding that inhibitory cell class molecular layer interneurons play a key role in modulating plasticity and learning behavior. This discovery provides fundamental insights into neural computation and mechanisms underlying motor learning.
Researchers discovered a high infection rate of Purkinje neurons with HHV-6 in patients with bipolar disorder and/or severe depression. The study suggests viruses can cause cognitive disturbances leading to mood disorders, contradicting the belief that dormant viruses never cause disease.
A new model simulates Purkinje cells, helping researchers understand their function in controlling body movement. The model demonstrates that climbing fibers can teach these cells to fire with analogue information, enabling nuance and fine targeting.
Researchers at Kyoto University have discovered that MTSS1 controls the branching of neurons by activating one pathway and inhibiting another. This protein plays a dual role, regulating actin filaments to facilitate efficient and uniform coverage of the surrounding environment.
Researchers at Johns Hopkins Medicine have made significant discoveries about the cerebellum's role in learning and prediction. By studying monkey brains, they found that Purkinje cells communicate through simple spikes (predictions) and complex spikes (error feedback), organizing into small groups to learn together.
Researchers at Boston Children's Hospital used stem cell technology to create Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome often linked to autism. The lab-grown cells showed structural abnormalities and impaired development of synapses, which may help explain how autism develops at the molecular level.
Scientists at IST Austria have resolved the role of Synaptotagmin 7 during inhibitory synaptic transmission, showing it regulates asynchronous transmitter release and facilitation. The study found Synaptotagmin 7 ensures efficient and frequency-independent signal transmission in the cerebellum and hippocampus.
Researchers at Hokkaido University found that the GLAST molecule facilitates functional wiring of brain cells involved in motor coordination. Glutamate transporters, like GLAST, enable high-fidelity signal transmission between nerve cells.
Researchers at MPFI have developed a novel technique to selectively target cerebellar interneurons, which are crucial for regulating motor behavior and learning. This breakthrough allows scientists to manipulate the activity of these cells, providing new insights into the role of interneurons in cerebellar function.
Researchers developed a new method to target select cells in adult brains, using an optogenetic technique. By altering the function of brain circuits and changing behavior, scientists can better understand the roles of specific cell types in the complex brain circuitry.
Researchers created a new iPS-cell model to study spinocerebellar ataxia type 6, finding that mature Purkinje cells with the SCA6 mutation become vulnerable when deprived of thyroid hormone. The team discovered compounds that can suppress this vulnerability and prevent cell death.
Researchers discovered that cutting parallel fibres in normal mice results in three distinct phases of degeneration, hypertrophy, and remodelling. In contrast, mice lacking the GluD2 receptor remain stuck in the degenerative phase. This suggests that GluD2 plays a crucial role in regulating nerve regeneration.
Researchers at NCBS discovered that Purkinje cells have two modes of electrical signaling based on voltage: a constant 'up' state and a burst-like 'down' state. This allows the cells to choose whether to respond to instructions or not, and the study suggests that this mechanism may play a role in motor learning.
Researchers at NYU Langone Medical Center have identified a protein known as Pcp4 as a regulator of the heart's rhythm in mouse models. Disruption of the Pcp4 gene leads to ventricular arrhythmias and increased mortality. The study suggests that targeting Pcp4 could lead to new treatments for arrhythmias.
Researchers at Lund University have discovered a new learning mechanism in individual nerve cells, which enables the brain to time its reactions and control complex processes like blinking and intelligible speech. This discovery has significant implications for rehabilitation following stroke, autism, ADHD, and language problems.
Researchers at University of Pennsylvania showed how brain distinguishes between errors of different magnitudes, critical for fine-tuning motor control. They found that longer air puffs corresponded to more climbing fibers sending signals to Purkinje cells, allowing the brain to learn and adapt.
A study of GRID2 gene mutations in spinocerebellar ataxia patients reveals no point mutations or insertion/deletion mutations. Instead, polymorphic deletions and single nucleotide variations were identified, with similar frequencies in patients and controls.
Researchers discovered a comprehensive catalogue of proteins manufactured in specific parts of Purkinje neurons using cutting-edge methods TRAP and CAGEscan. This finding holds key to understanding molecular events and potential insights into diseases associated with Purkinje cells.
A team of researchers at the University of Pennsylvania has made a groundbreaking discovery about how climbing fibers provide feedback to Purkinje cells, allowing them to detect legitimate error signals amidst random firing. This knowledge will be fundamental to future studies of fine motor control and learning.
Researchers identified KCa3.1 ion channel in Purkinje cells, allowing them to filter sensory input and coordinate body movements. This discovery fills a gap in understanding how neurons process information.
Scientists discover that genetic dysfunction in multiple cell types contributes to SCA7, a devastating neurological disorder. Targeting specific cell types may improve treatment and slow disease progression.
Using optogenetics, researchers were able to target one cell type and influence activity of nerve cells with laser light. The study found that activation of a specific G-protein-coupled receptor changed the activity pattern of Purkinje cells, leading to motor deficits in mice.
A study published in Neuron reveals that the loss of Nna proteins causes mitochondrial dysfunction, leading to severe cell death in mice and fly models. Researchers believe this discovery could provide insights into human neurodegenerative disorders like Parkinson's disease.
A defective protein in spinocerebellar ataxia type 5 (SCA5) damages nerve cells by cutting the number of synaptic terminals and disrupting intracellular transportation. The study suggests that the complex containing beta-III-spectrin, dynactin, and dynein might also snag microtubules to prevent degeneration.
A new nucleotide, 5-hydroxymethylcytosine, has been discovered in the mouse brain, opening a new front in epigenetic research. This discovery may challenge existing approaches to investigating DNA methylation and could have significant implications for understanding gene regulation.
A Stanford study reveals that HLA molecules, crucial for immune function, also contribute to brain circuits involved in learning and memory. The absence of these molecules can enhance motor learning but may compromise other learning abilities.
A study with sheep found that blocking acid-sensitive potassium channels prevents damage to the fetal cerebellum, which is vulnerable to injury from alcohol. The researchers also found that a drug called doxapram can block these channels, preventing damage and reducing the number of Purkinje cells in the cerebellum.
Researchers identify nonsignaling glial cells as a guiding scaffold for synapse formation in the developing brain. The discovery sheds light on neural network formation and may hold clues to understanding disorders like autism.
Researchers discovered a neural computer in the cerebellum that calculates inertial motion by combining rotational and gravity signals. The brain uses this information to determine its movement through space, even when head acceleration is present.
Scientists identified a molecular switch that causes differentiation of neurons in the cerebellum, a part of the brain controlling movement. The discovery provides new insights into brain formation mechanisms and potential therapeutic applications for rare diseases like cerebellar ataxias.
Researchers found that genetic instructions are not executed properly, leading to a buildup of malformed proteins in brain cells. This defect is caused by a subtle mistake in the loading of amino acids onto transfer RNAs.
Researchers genetically engineered mice whose hearts glow with a green light, shedding light on heart development. The study reveals the presence of specialized cells that delay beating between heart chambers, improving understanding of irregular heartbeats and basic physiology.
Researchers discovered that gene-dependent loss of precision in Purkinje cells causes hereditary movement disorder ataxia type-2. A drug called EBIO improved motor coordination in ataxic mice by activating calcium-activated potassium channels.
Researchers found SCA5 mutations in 90% of Lincoln's descendants, suggesting the past president may have had a neurological disorder. The discovery provides insight into molecular mechanisms common to SCA5 and other neurodegenerative diseases.
Researchers at St. Jude Children's Research Hospital identified Cbln1 as a key protein maintaining correct synaptic connections in the adult brain. Without Cbln1, synapses weaken and new nerve connections form, disrupting brain function.
Spinocerebellar ataxia type 1 (SCA1) is caused by a toxic buildup of the protein Ataxin-1, leading to damage in cerebellar Purkinje cells. Researchers discovered that glutamine repeats in the protein cause toxicity, which can also affect other neurodegenerative diseases like Huntington's and Parkinson's.
A study found that mice with silenced small-conductance calcium-activated potassium (SK) channels in the DCN had increased firing rates and ataxia. Despite this, Purkinje cell input into the DCN remained intact, indicating a direct relationship between SK channel regulation and proper muscle coordination.
A new study reveals that patients with gluten sensitivity may experience neurological dysfunction without gastrointestinal symptoms. The research found antibodies against Purkinje cells and cross-reacting antibodies against gluten, suggesting a potential link between gluten consumption and brain damage.
A new study has identified the key step in simple motor learning, which involves the reduced response to glutamate in Purkinje cells. By examining this process, researchers hope to create a mouse that can't reduce the number of glutamate receptors on its Purkinje cells and test if it affects learning.