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Unraveling the mysteries of habit formation

Researchers at Kyoto University developed a new training method to study habit formation in mice, revealing two distinct brain circuits managing different aspects of habits. The first circuit determines whether behavior becomes a habit, while the second controls execution levels.

SourceKyoto University·JournalNature Communications·DateJul 27, 2026

Novel study shows physical activity reshapes neural connectivity and makes the brain more resilient after childhood trauma

Research in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reveals that lifetime physical activity can reshape neural connectivity, strengthening the brain's internal communication and optimizing its response to stress. The study challenges traditional deficit-focused views of adversity, offering a more dynamic and hope...

SourceElsevier·TypeImaging analysis·DateMar 17, 2026

Type 2 diabetes may suppress reward

A rat study found that type 2 diabetes can suppress the activity of the anterior cingulate cortex, a region critical for cognition and emotions. This weakening affects reward signals and leads to altered behavior, highlighting a potential link between T2D and psychiatric disorders.

SourceSociety for Neuroscience·JournalJNeurosci·DateMar 24, 2025

Decoding the neural basis of affective empathy: how the brain feels others' pain

A study by Dr. Keum Sehoon's team identified key neural ensembles in the anterior cingulate cortex that encode empathic freezing, a behavioral response to witnessing distress in others. The researchers found that observing another's pain triggers activation in the ACC as if the observer were experiencing pain themselves.

SourceInstitute for Basic Science·JournalNature Communications·TypeExperimental study·DateMar 10, 2025

How the brain distinguishes between pain and itch

Researchers discovered distinct neuronal populations in the ACC process pain and itch information separately, with stimulus-specific neurons receiving differentiated synaptic inputs from the mediodorsal thalamus. Suppressing these neurons reduced corresponding sensations without affecting the other.

SourceInstitute for Basic Science·JournalNature Communications·TypeExperimental study·DateMar 4, 2025

Neuroscientists discover how the brain slows anxious breathing

Researchers at the Salk Institute identified a specific brain circuit responsible for slowing anxious breathing, connecting the frontal cortex to the brainstem. This discovery may offer a scientific explanation for the beneficial effects of practices like yoga and mindfulness on alleviating negative emotions and could lead to the devel...

SourceSalk Institute·JournalNature Neuroscience·DateNov 19, 2024

Brain mechanisms underlying sensory hypersensitivity in a mouse model of autism spectrum disorder

A study by IBS researchers has identified the anterior cingulate cortex (ACC) as a key region responsible for sensory hypersensitivity associated with autism spectrum disorders. The team discovered that ACC hyperactivity and brain-wide hyperconnectivity contribute to sensory abnormalities in Grin2b-mutant mice.

SourceInstitute for Basic Science·JournalMolecular Psychiatry·TypeExperimental study·DateMay 9, 2024

Lack of focus doesn’t equal lack of intelligence — it’s proof of an intricate brain

Researchers at Brown University's Carney Institute for Brain Science discovered how the brain coordinates attention and filtering functions to perform complex tasks. The study found that multiple brain regions work together to adjust focus and filter out distractions, providing insight into human cognitive flexibility.

SourceBrown University·JournalNature Human Behaviour·TypeExperimental study·DateMar 8, 2024

Targeted ultrasound can change brain functions for up to an hour after intervention

A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.

SourceUniversity of Plymouth·JournalNature Communications·TypeExperimental study·DateSep 12, 2023

Serotonin booster leads to increased functional brain connectivity

A new study found that the serotonin booster prucalopride increased functional brain connectivity in healthy adults, particularly between cognitive networks. The results suggest that prucalopride may improve cognitive function and have therapeutic potential for depression patients.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeExperimental study·DateJun 13, 2023

Chronic pain-induced depression: Underlying mechanism revealed in mice, showing how ketamine acts as antidepressant in chronic pain

Researchers have uncovered the underlying mechanism driving depressive systems in chronic pain, identifying a potential therapeutic target for treatment. Tiam1 protein modulates neural connections, leading to hypersensitivity and depression; ketamine blocks this effect, alleviating symptoms.

SourceUniversity of Alabama at Birmingham·JournalJournal of Clinical Investigation·TypeExperimental study·DateJan 30, 2023

When a task adds more steps, this circuit helps you notice

A new study by neuroscientists at MIT's Picower Institute finds that the anterior cingulate cortex (ACC) and motor cortex collaborate to update understanding and behavior when a task requires more steps. The ACC helps M2 adjust to new rules, but reduced activity leads to increased negative outcome encoding cells' activity in M2.

SourcePicower Institute at MIT·JournalNature Communications·TypeExperimental study·DateAug 5, 2022

CityU scientists reveal new neurocircuitry essential for animals to sense environmental cues of imminent danger

Researchers at City University of Hong Kong discovered a new neural mechanism that enables animals to perceive and integrate environmental cues, such as air puffs and sounds, to initiate defensive behavior. This finding has implications for understanding schizophrenia patients' auditory hallucinations.

SourceCity University of Hong Kong·JournalCell Reports·TypeExperimental study·DateMay 3, 2022

Rats exchange information about danger in a reciprocal fashion

In a groundbreaking study, researchers found that rats can transfer information about danger to each other in both directions, influencing their responses to threats. The study suggests that this reciprocal exchange of information could enhance the detection of danger within groups, similar to cross-species eavesdropping.

SourcePLOS·JournalPLOS Biology·DateDec 5, 2019

A 'cingular' strategy for attack and defense

The study found that two specific brain regions, the posterior cingulate cortex and rostral anterior cingulate cortex, are activated when making defensive or offensive strategies. This suggests that intuition plays a key role in rapid strategic decisions, rather than deliberate reasoning.

SourceRIKEN·JournalNature Neuroscience·DateApr 20, 2015

The rest of the brain gets in the way

A study using fMRI scans found that unnecessary brain activity hinders learning, while reduced neural connections facilitate faster skill acquisition. The researchers' novel analysis methods revealed complex brain networks and community structures that correlate with individual differences in learning rates.

SourceUniversity of Pennsylvania·JournalNature Neuroscience·DateApr 7, 2015

The brain game

Researchers found that quicker learners use different brain regions and have more interconnected networks, while slower learners rely on more individualized brain activity. The study provides insight into the neural mechanisms behind skill learning and practice.

SourceUniversity of California - Santa Barbara·JournalNature Neuroscience·DateApr 6, 2015

Political views are reflected in brain structure

A new report links differences in brain structure to political orientation, finding that liberals have larger anterior cingulate cortexes and are better at coping with conflicting information, while conservatives have larger amygdalas and are more sensitive to threats.

SourceCell Press·JournalCurrent Biology·DateApr 7, 2011

Is there a seat of wisdom in the brain?

Researchers at UC San Diego School of Medicine have reviewed the neurobiology of wisdom, identifying key brain regions involved in its attributes such as empathy, compassion and emotional stability. The study suggests an optimal balance between primitive and pre-frontal cortex brain regions may enhance wisdom.

SourceUniversity of California - San Diego·JournalArchives of General Psychiatry·DateApr 6, 2009