Articles tagged with Brain Structure
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Researchers at the University of Notre Dame investigated how brain networks are organized and work together to form a unified system. They found evidence for system-wide coordination in the brain that is both robust and adaptable, suggesting that intelligence reflects how brain networks are coordinated and dynamically reconfigured.
Researchers at Karolinska Institutet created the first activity-based maps of the prefrontal cortex, revealing a hierarchy of information flow rather than tissue structure. This challenges traditional definitions of brain regions and has major implications for understanding brain organisation overall.
A recent study reveals that tissue stiffness regulates the production of key signaling molecules in the brain, using the mechanosensitive protein Piezo1. This discovery opens new avenues for understanding development and tackling diseases such as cancer.
Research reveals structural brain changes in older adults affect ability to shift between tasks and update environmental information. These changes may lead to deficits in behavioral adaptability, emphasizing the importance of identifying age-related brain structure changes.
Researchers developed a unified multimodal framework to analyze joint aging changes in brain function and structure. The study identified two primary aging patterns: synergistic declines in motor control and higher-order cognition, and contradictory adaptations in visual areas.
A team of researchers has reconstructed how the cerebellum establishes its connections with the rest of the brain during earliest stages of life. The work describes the phases in which these neural connections emerge, expand, and are refined, offering a comprehensive map of cerebellar projections across the mouse brain.
Researchers at USC have identified four distinct layers of specialized cell types in the CA1 region of the mouse hippocampus, a structure vital for memory formation. This discovery changes our understanding of how information is processed in the brain and could explain why certain cells are more vulnerable in diseases like Alzheimer's ...
Researchers at the University of Plymouth have successfully used transcranial ultrasound stimulation (TUS) to change the function of a deep region of the human brain, specifically the nucleus accumbens. This tiny element is triggered by enjoyable experiences and helps us learn behaviours that lead to rewards.
Researchers found that the prefrontal cortex sends customized signals to visual and motor regions, influencing their activity based on arousal levels and movement. The study reveals distinct roles of prefrontal subregions in shaping visual processing, with one region enhancing stimuli detection and another dampening irrelevant stimuli.
A USC study mapped tiny structural differences in white matter among children and young adults with autism, pinpointing patterns that earlier methods would have missed. The findings highlight the importance of developing new methods to better understand brain differences in autism.
Researchers at Tulane University discovered a new nerve cell signaling mechanism that can turn on pain signaling after injury, potentially leading to safer treatments. The discovery of enzyme vertebrate lonesome kinase (VLK) offers a new way to influence cell behavior and could simplify drug development.
Researchers from UC San Francisco have identified the superior temporal gyrus brain region responsible for tracking words in a foreign language. The study shows that this region learns to recognize word boundaries through years of experience, enabling fluent speakers to distinguish individual words.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers created BraDiPho, a 3D atlas of brain connections, combining clinical neuroscience, artificial intelligence, and neuroanatomy. The tool facilitates precise identification of white matter connections, opening up new therapeutic perspectives for neurological diseases.
The study identified dozens of genetic regions that influence the size and thickness of the corpus callosum and its subregions. The research team created an AI-powered tool that finds and measures the corpus callosum in brain MRI scans automatically, allowing for unprecedented analysis of brain structure at scale and precision.
Researchers at NUS Medicine found that social interactions trigger memory-enhancing signals to the CA1 region of the hippocampus through metaplasticity, strengthening 'memory proteins'. Regular social interactions are crucial for this process, as time-limited effects suggest.
Researchers at UTA are exploring how guided cognitive training can improve brain performance, particularly in navigation and memory. The study found that functional brain changes support behavioral differences, rather than increased brain volume.
A recent study found that preserving just one centimeter of corpus callosum fibers is enough to maintain information exchange between the two brain hemispheres, preventing neurological symptoms. The research challenged long-held assumptions about the relationships between brain structure and function.
A high-resolution growth chart of the mouse brain has been created to study key brain cell types and their changes during development. The atlas reveals a dynamic sequence of brain growth and maturation in response to genetics and external stimuli, with implications for understanding neurodevelopmental disorders.
A new study reveals how prenatal alcohol exposure impairs key brain cells and circuits, leading to cognitive inflexibility and increased risk of compulsive alcohol use. Researchers identified a specific brain cell affected by early alcohol exposure, providing a clear target for developing more effective treatments of FASD.
Researchers at Virginia Tech found that adjusting molecular processes can improve memory in older subjects. They used CRISPR-dCas13 and CRISPR-dCas9 to target age-related changes in K63 polyubiquitination and IGF2, two genes linked to memory formation.
Researchers have discovered that astrocytes can integrate signals from several neurons at once, achieving a new level of spatial and temporal integration. This allows astrocytes to coordinate broader responses and enables new cognitive functions.
A deep learning model achieved up to 98% accuracy in distinguishing autistic from neurotypical participants, providing clear insights into brain regions most influential to its decisions. The model could benefit autistic people and clinicians by offering accurate and explainable results to inform assessment and support.
A study published in Science Advances reveals that an autism-linked mutation disrupts brain circuits responsible for erasing fear memories, leading to PTSD-like symptoms. By reactivating specific neurons, researchers were able to reverse the behavioral and physiological abnormalities.
The brain chooses routes to process information by adjusting balance between slow (theta) and fast (gamma) rhythms, enabling flexible adaptation to context and cognitive demands. This flexibility allows the brain to select different sources of information, such as sensory stimuli or stored memory.
Researchers analyzed neuroimaging data from over 650 individuals aged 8 to 21, discovering a key organizational shift in the dorsal prefrontal cortex. The study found that this refinement of brain architecture is driven by specific changes in the medial part of the prefrontal cortex.
Researchers found that brain activity in regions responsible for managing specific body parts remains consistent before and after arm amputation. The study's results suggest that standard phantom pain treatments may need to be rethought and could improve the development of neuroprosthetics and brain-computer interface technologies.
A recent study by researchers at The University of Osaka discovered the crucial role of DNA repair enzyme Polβ in safeguarding the developing brain from harmful mutations. Accumulation of indel mutations near CpG sites may contribute to neurodevelopmental disorders.
A study found that athletes from high-disadvantage neighborhoods had a thinner outer layer in certain areas of the brain and smaller brain volumes, which can be early signs of neurodegeneration. Researchers suggest that recognizing stressors can help inform more equitable approaches to protecting long-term brain health.
Researchers found that the primary somatosensory cortex, responsible for processing sensory information, has a layered structure that ages differently. The middle and upper layers remain stable or even thicken with age, while the lower layers show age-related degeneration, providing evidence for neuroplasticity.
Researchers aim to uncover how menopause and lifestyle factors shape brain aging in women during midlife. The three-year project will analyze MRI scans and health data from thousands of women worldwide to track changes in brain structure and connectivity.
The Living Brain Project at Mount Sinai has collected over 300 brain tissue samples, revealing that 80% of genes exhibit different expression levels in living versus postmortem brain tissue. This challenges decades of neuroscience research based on postmortem samples.
A new analysis of a 500 million-year-old fossil suggests that arachnids, including spiders and scorpions, evolved in the ocean before adapting to land. The discovery was made by studying the brain and nervous system of an ancient marine arthropod called Mollisonia symmetrica.
A study from the UJI reveals how the brain interprets social hierarchies and emotional facial expressions through the anterior temporal lobe. The upper part of this region is strongly activated when individuals make decisions based on emotional facial expressions, particularly in those with high levels of anxiety.
Researchers at Stanford University have developed new technology to image brain waves, revealing three new types of brain activity. The ultra-sensitive optical instruments can detect signals of genetically engineered proteins and show neural activity across the majority of the mouse neocortex.
A new study from UC San Francisco challenges the traditional view of how the brain strings sounds together to form words and orchestrates the movements to pronounce them. The brain relies on a wider network of neurons across many brain areas, centered in the middle precentral gyrus, to coordinate speech-motor sequencing.
Scientists have developed a new multiscale modeling approach that can simulate how microscopic changes affect macroscale brain activity. The framework successfully predicted the effects of anesthesia on synaptic receptors, bridging the gap between molecular and whole-brain levels.
A recent study has discovered a connection between brain damage and an increased likelihood of committing crimes. The research, led by Harvard Medical School and the University of Colorado Anschutz Medical Campus, found that damage to the right uncinate fasciculus was linked to criminal behavior.
Researchers used advanced neuroimaging and the Julich-Brain Atlas to identify specific brain networks linked to psychopathy, finding reduced volumes in multiple regions including basal ganglia, thalamus, and cortex. This study advances research on neuropsychobiological correlates of aggression.
Scientists have discovered the structure and shape of key receptors in the cerebellum, a region critical for movement, balance, and cognition. This finding could lead to the development of therapies to repair damaged synapses and improve brain function.
Dr. Sophia Shi's groundbreaking research reveals that the glycocalyx deteriorates with age, leading to blood-brain barrier dysfunction and cognitive decline. Her work provides concrete molecular targets for drug development and may lead to treatments that address the root causes of neurodegeneration.
A new study published in Neuron has identified a brain region, the fusiform gyrus, as key to distinguishing between real and imagined experiences. The region's strength of activity can predict whether someone judges an experience as real or imagined.
Using an algorithm called the Krakencoder, researchers at Weill Cornell Medicine mapped how the brain's anatomical connections and activity patterns relate to behavior. The tool accurately predicted individual's functional connectome about 20 times more than previous approaches, also mapping age, sex, and cognitive performance scores.
Researchers found that greenspace exposure is associated with widespread patterns of structural brain development during early adolescence, leading to better academic and mental outcomes. This study highlights the importance of integrating natural environments into urban and educational settings.
A new study from UC Berkeley reveals that the depth of small grooves on the brain's surface is correlated with increased connectivity between regions involved in reasoning. The researchers found that these tertiary sulci, unique to humans, may help explain individual differences in cognitive performance and serve as diagnostic indicato...
Researchers discovered similarities between AI and human brains with aphasia, offering new insights into diagnosis and improving AI's fluency. The study suggests that understanding internal patterns in AI models may lead to smarter and more trustworthy AI.
A new USC-led study found a significant link between type 2 diabetes and cortical thickness in older adults from various populations. The researchers discovered that individuals with T2DM exhibited thinner cortex, particularly in temporal and parietal regions critical for memory and cognitive function.
Researchers at NYU Tandon School of Engineering identified a crucial role for the dorsolateral prefrontal cortex in mapping sounds to meaning, shedding light on the neural dynamics underlying word retrieval. The study's findings have significant implications for both neuroscience and clinical interventions.
A new brain atlas developed by researchers at Duke University will increase precision in measuring changes in brain structure, making it easier to share results. The tool, the Duke Mouse Brain Atlas, provides a detailed map of the entire mouse brain, from large structures down to individual cells and circuits.
Dr. Seymour Reichlin's remarkable career spanned five decades, marked by scientific excellence, mentorship, and generosity. His influence on neuroendocrinology has been profound, with ongoing contributions at age 100 revealing new insights into Alzheimer's disease and ecstatic mysticism.
Researchers discovered that the brain suppresses the current action without using another mechanism to inhibit it, enabling seamless transitions between actions. This finding could lead to the development of biologically-inspired robotic systems and improve clinical treatments for Parkinson's patients.
A new brain imaging study found that age and brain shape significantly impact the strength of connections between olfactory brain regions in dogs. Younger dogs and those with elongated brains had stronger functional connectivities, while older dogs and rounder-headed individuals performed worse in smell tests.
A study found that marathon runners experience a decrease in brain myelin content, but it recovers fully two months later. Myelin acts as an energy reserve, and the study opens new insights into brain energy metabolism.
A new USC-led study using fMRI reveals the neural mechanisms that contribute to urinary incontinence in stroke survivors. The research found significant differences in brain activity during voluntary versus involuntary bladder contractions, presenting potential pathways for targeted therapies.
Researchers analyzed brain tissue from individuals with severe Tourette syndrome and identified three key changes: altered gene activity, regulatory element modifications, and interneuron loss. These findings provide unprecedented insights into the disorder's biology and may explain why individuals experience involuntary movements and ...
A study found that brain activity can predict a person's political affiliation with 80% accuracy when making food purchases. Researchers used fMRI to measure brain activity in Republicans and Democrats, finding distinct neural patterns for each group.
A new study by UCL researchers found that people with visual Alzheimer's disease have a unique distribution of proteins and markers in their brain, leading to symptoms such as reading difficulties. In contrast, those with memory-led Alzheimer's disease have different protein patterns, resulting in symptoms like memory loss.
A new digital 'translator' for brain studies enables researchers to map the brain in a standardized way, facilitating discoveries and treatments for various disorders. The open-source software allows for the comparison of brain imaging data with widely used brain atlases, promoting commonalities across findings.
Researchers created a powerful new computational and artificial intelligence tool that can generate high-resolution 3D maps of the brain in mice, allowing users to zoom in and out and peer into the full set of molecules producing energy for brain functions. This breakthrough brings scientists closer to understanding the role of metabol...
A new study by MIT researchers finds that constructed languages such as Esperanto and Klingon elicit similar responses in the brain's language-processing network, suggesting that meaning is a key feature of language. This discovery helps define some of the key properties of language and narrows down the question of what a language is.