Articles tagged with Cerebellum
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A team of researchers used AI to analyze the activity of genetic control elements in the developing mammalian cerebellum, identifying specific elements unique to the human lineage. The study reveals how these elements may have contributed to key evolutionary innovations in the human brain, including the expansion of the cerebellum.
A new study published in JAMA Network Open found that acupuncture is effective in reducing migraine without aura pain and improving functionality. The research identified specific brain network connections that predict treatment outcomes, enabling a personalized approach to pain management.
Researchers discovered the cerebellum's key role in regulating the brain's reward system in people with schizophrenia. Stronger cerebellar regulation is associated with reduced negative symptoms, while weaker regulation increases symptoms. This finding opens up new avenues for targeted therapeutic interventions.
Researchers discovered cerebellar signals strengthen visual cues during learning, facilitating precise visuomotor associations. This finding highlights the cerebellum's crucial role in cognitive functions beyond motor control.
A team of researchers has reconstructed how the cerebellum establishes its connections with the rest of the brain during earliest stages of life. The work describes the phases in which these neural connections emerge, expand, and are refined, offering a comprehensive map of cerebellar projections across the mouse brain.
Researchers identified the α1D norepinephrine receptor as a key player in stress-induced motor incoordination associated with ataxias. The team showed that blocking this receptor restored normal activity of Purkinje cells, which could lead to new treatment approaches for patients with ataxia type 2.
Research from Kyoto University found that continuing to play a musical instrument into old age preserves brain function and prevents atrophy in the putamen. Long-term practice showed no decline in verbal working memory performance or gray matter volume, while short-term practice improved memory function for four months.
A team of researchers constructed a cross-species single-nucleus RNA-seq atlas of amniote brains, uncovering conserved and divergent cell-type evolution. Functional divergence or loss of paralogous genes significantly drove the evolution of brain cell types, with distinct expression patterns across species.
Researchers discovered that Purkinje cells in the cerebellum signal to stop tongue movement as it approaches a target, allowing for precise control of tongue movements. This understanding is crucial for developing treatments for symptoms linked to cerebellar dysfunction, such as vocal muscle spasms and speech disorders.
Researchers developed DeepCeres, a software that uses AI tools to measure 27 structures of the cerebellum with improved precision. This will help in studying neurological pathologies such as ALS, schizophrenia, and Alzheimer's diseases.
Researchers at Kyoto University investigated the effects of two-hit stress on mice, finding that it leads to increased microglia activity, neuronal loss, and decreased brain connectivity. Microglia replacement therapy showed promise in rescuing affected mice, with female mice exhibiting higher stress resilience.
Researchers at Kyoto University investigated the effects of two-hit stress on mouse behavior, revealing significant changes in the cerebellum. The study found increased microglia turnover, neuronal loss, and decreased brain connectivity, correlating with anxiety-like behaviors and mental disorders.
A study published in the Journal of Neurosurgery found that surgery can alleviate psychiatric distress and improve cognitive function in patients with Chiari Malformation type 1. Nearly 90% of patients showed improvements in cognitive function or psychiatric symptoms, with many reporting a significant reduction in brain fog.
Research finds that cerebellar serotonin alleviates anxiety-like behavior in mice, suggesting a new treatment approach. The study's findings counter previous ideas and provide insights into the neural circuits driving anxiety.
A global study will explore structural changes in the brains of people with bipolar disorder and compare them to major depression. The project aims to develop new tools for diagnosis and treatment, leveraging unprecedented sample sizes from over 3,500 individuals with BD and 9,000 healthy controls.
Scientists at St. Jude Children's Research Hospital found a link between the chromosomal disorder 22q11.2 deletion syndrome and schizophrenia, with malformations in the cerebellum causing Tbx1 gene loss leading to improper skull formation.
Researchers have identified three distinct subtypes of Chiari type-1 malformations with distinct characteristics, enabling physicians to develop treatment protocols for patients. The study used artificial intelligence to analyze data from over 1,200 patients and identified patterns that can inform medical decision making.
Research highlights cerebellum's essential role in refining motor movements and improving social task performance in individuals with autism. Non-invasive brain stimulation techniques like magnetic stimulation have shown promise in enhancing cognitive tasks.
Studies show that the cerebellum is critical for forming stable memories for sensorimotor skills, largely independent of short-term memory systems. Researchers found that longer time intervals between trials increased reliance on impaired long-term memory.
Researchers comprehensively reviewed cerebellar involvement in Parkinson's disease, highlighting the pathophysiological role of the cerebellum in motor and non-motor symptoms. Studies showed abnormal α-synuclein aggregation, neurodegeneration, and altered functional connectivity between the cerebellum and other brain regions.
A new study reveals that more than half of strokes causing ataxia are located outside the cerebellum but affect a specific brain network. This discovery changes our understanding of ataxia's neural mechanisms and may lead to safer treatments for patients.
Researchers identified genes associated with a thinner cortex and smaller cerebellum, which can lead to uncontrollable shaking of hands. The study also found that faulty protein disposal affects cell function and disrupts neural pathways, making it difficult to treat the condition.
A recent study discovered that knocking out a key gene, ASTN2, in mice results in changes to cerebellar structure and behavior. The knockout mice exhibited reduced socialization and communication, increased hyperactivity and repetitive behavior, similar to hallmark traits of autism spectrum disorder.
A recent study has identified a blood protein called fibrin as the root cause of developmental delays and brain damage in preterm infants. The researchers found that fibrin interferes with a cell-signaling pathway essential for neuron creation, particularly in the cerebellum.
A recent study found that the cerebellum plays a crucial role in regulating thirst, with the hormone asprosin activating Purkinje neurons to enhance water intake. This discovery has significant implications for managing thirst disorders such as polydipsia and hypodipsia, for which current treatments are scarce.
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
The study found that the cerebellum uses information about errors to refine movement and contributes to cognitive functions. The posterior lateral region of the cerebellum is interconnected with the prefrontal cortex and helps shape cognition.
Researchers discovered a class of cerebellar inputs, called climbing fibres, are essential for associative learning to occur. These
McGill researchers have made a groundbreaking discovery about Spinocerebellar ataxia type 6, a rare and devastating neurodegenerative disease. Damaged mitochondria in the cerebellum are found to contribute to disease progression.
Scientists at UCSF discovered a new way to test for autism by measuring how children's eyes move when they turn their heads. Children with severe autism have an unusual form of the vestibulo-ocular reflex, which can be measured with a simple eye-tracking device.
A recent study reveals a brain mechanism linking physical exercise to improved mood by activating a hypothalamo-cerebello-amygdalar circuit. The circuit, involving the cerebellum, bridges motor and emotional systems, indicating that motor-dependent alleviation of anxiety may be linked to the persistence of exercise on mood.
Researchers found an adaptive increase in cerebellum size in fossil vertebrates, enabling powered flight. The study combined PET scans with fossil data, revealing increased brain activity in the cerebellum and optic flow pathways during flight.
Spinocerebellar ataxia type 6 is a rare disease that disrupts brain function and coordination. Researchers have identified endosomal dysfunction as a key contributor to the disease's progression, and found a potential treatment using the compound 7,8-DHF.
Researchers at ISTA investigated the crucial set of synapses between neurons within the cerebellum, uncovering details of their function and development. The study used advanced techniques to look at the inhibitory synapses in great detail, revealing how they delicately influence the cell's signal output.
A study from Duke University found that people with PTSD have a significantly smaller cerebellum, especially in areas related to emotion and memory. Researchers hope this discovery will lead to targeted treatments and more research on the brain region's role in PTSD.
A novel human brain organoid model generates all major cell types of the cerebellum, including functional Purkinje neurons. This breakthrough provides a new way to explore cerebellar development and disorders, advancing therapeutic interventions.
Researchers at Tohoku University found that Bergmann glial cells in the cerebellar vermis regulate the volume of aggression in mice. The study suggests that adjusting glial activity in the cerebellum could lead to therapeutic strategies for managing anger and aggression.
Researchers have generated comprehensive genetic maps of the developing cerebellum in humans, mice, and opossums. The study reveals ancestral and species-specific cellular characteristics spanning over 160 million years of mammalian evolution.
Researchers discovered that cerebellar nuclei make a surprising contribution to associative learning by strengthening connections with mossy fibers. Optogenetic experiments also showed that the nuclei can support well-timed learning. The study's findings have implications for understanding cerebellum function and potential treatments f...
A recent study published in Scandinavian Journal of Medicine and Science in Sports found that physical fitness since childhood is associated with increased cerebellar grey matter volume in adolescents. Those with better neuromuscular fitness had larger Crus I grey matter volume, while those with cardiorespiratory fitness had smaller to...
A research team at the University of Minnesota Medical School has identified the cerebellum as a critical component in coordinating brain networks essential for social recognition memory. This discovery holds promise for the development of targeted therapies for neurodegenerative disorders, which often feature loss of recognition memory.
Researchers analyzed 56 mammalian species to study the diversity and evolution of cerebellar folding and its connection to cerebral anatomy. The findings reveal a consistent pattern across species, suggesting a common mechanism underlying brain folding.
Researchers describe a groundbreaking case of bilateral TMS treatment for chronic ataxia after hemorrhagic stroke, resulting in significant improvements in walking speed and balance. The treatment showed promise as the patient regained independence in daily activities.
Researchers found that nearly all Purkinje cells in the human cerebellum have multiple primary dendrites, which contradicts the traditional understanding of a one-to-one relationship between climbing fibers and Purkinje cells. This discovery was made possible by analyzing thousands of cells from both human and mouse tissue using immuno...
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
Researchers identified 756 patients with rare forms of spinocerebellar ataxias (SCA), revealing diverse disease manifestations and symptoms. The study highlights the importance of sequencing the genome to improve diagnosis and treatment for these previously underdiagnosed cases.
Researchers discovered nanoscopic tunnels that connect precursor cells in the cerebellum as they mature into neurons. These tunnels enable molecular exchange and physical migration of pre-neuronal cells across layers, shedding light on brain connectivity and development.
A study found that practicing music and active listening can alter cognitive decline in healthy seniors by promoting brain plasticity. The researchers discovered an increase in grey matter volume in four brain regions involved in high-level cognitive functioning.
Researchers studied brain activity in rats as they learned a fine motor task, discovering synchronous low-frequency oscillatory activity that coordinated neural spiking in the motor cortex and cerebellum. This activity may serve as a biomarker for skill learning and a target for electric stimulation to promote motor recovery after stroke.
A new optogenetic tool, OPN4-mGluR1, allows researchers to modulate mGluR1 signalling in the cerebellum using light. This enables the study of synaptic plasticity and its role in motor learning, offering new possibilities for understanding cerebellar-associated diseases.
Researchers aim to create comprehensive maps of how neurons connect to each other, exploring neural circuits that underlie behavior. By studying connectivity and neural activity, scientists hope to understand the structure of the brain and its role in our sense of self.
Researchers at the Netherlands Institute for Neuroscience have developed a method to visualize the human cerebellum with unprecedented detail using a 7-Tesla MRI scanner. The technology enables the reconstruction of the cerebellum's patterns and layers, providing new insights into its role in motor skills and cognition.
Researchers at the University of Basel have discovered a new function of the cerebellum in storing emotional experiences, which is crucial for our survival. The study shows that increased activity in the cerebellum facilitates the storage of information in various areas of the cerebrum, leading to improved memory for emotional events.
Researchers have discovered that changes in dopamine D2 receptors in specific cerebellar cells can alter sociability and preference for social novelty. This finding has implications for understanding psychiatric disorders such as autism spectrum disorder, bipolar mood disorder, and schizophrenia.
Researchers at Ruhr-University Bochum found that stimulating cerebellar nuclei cells can prevent abnormal brain activity associated with absence seizures. The study used mice and optogenetic stimulation to confirm the therapeutic potential of targeted cerebellar stimulation.
A research team has identified a subset of cerebellar neurons that signal satiation after eating, leading to reduced food intake in mice. The findings suggest a novel target for therapies that could curb overeating and obesity.
Researchers at GIST create an optical technique called optical speckle image velocimetry that can image dynamic changes in cerebral blood flow, allowing for the diagnosis of brain health. The technique provides high-time resolution and measures both speed and direction of blood flow.
Researchers found a mutation in ELOVL4 enzyme impairs communication between neurons, leading to impaired motor control and coordination. The study provides new insights into the essential role of ELOVL4 in motor function and synaptic plasticity, suggesting potential therapeutic strategies for patients with spinocerebellar ataxia.
Researchers mapped genetic control elements of active genes in the mouse cerebellum, identifying over 200,000 control elements and a temporal pattern shared between different cell types. The study also shed light on the evolution of gene regulatory programmes in mammals.
A team of scientists has successfully developed an eyeblink test for pigs, a model species for studying nutritional neuroscience in human infants. The test assesses cognitive processing in the cerebellum and demonstrates associative learning in pigs.