Articles tagged with Epithelium
Researchers uncover a key ion channel, TRPM4, that regulates intestinal fluid balance and identify a new druggable site. This discovery provides a blueprint for designing targeted treatments for gastrointestinal disorders.
Researchers found that Reelin-based therapeutics could help restore the integrity of the gut barrier, reducing inflammation and symptoms of depression. The study suggests a promising new treatment targeting both brain and gut processes.
Researchers discovered a novel mode of contact between somatic and germ cells in the ovaries of two arthropod species, challenging the general understanding of epithelial layer function. The basement membrane, typically a barrier, is penetrated by follicle cells to establish direct contact with oocytes.
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.
Researchers discovered that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium, a vital layer of cells in the eye. This study provides a clearer understanding of why aging leads to eye disease and introduces a reliable laboratory model for testing new therapies.
Researchers discovered that gamma-actin increases the rigidity of cell membranes while beta-actin filaments are less stiff. This mechanism may contribute to hearing loss by affecting the apical membrane's stiffness essential for auditory function.
Scientists discovered that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins. These cells greatly increase in number when exposed to interferon-γ, presenting a potential target for therapies.
A new study from the University of Texas M. D. Anderson Cancer Center found that at least 3% of normal breast tissue cells in healthy women contain chromosome abnormalities associated with invasive breast cancer, which may guide future approaches to early detection.
Researchers at Osaka University uncovered the molecular details of how Drosophila fruit fly cells are removed during development, challenging the common assumption that clustered apoptosis poses a disadvantage to organisms. This study may help determine how abnormal cell death leads to congenital defects in humans.
A recent study published in Nature Cancer has discovered that cancer cells exhibit opposing pro and antitumor programs, with the former promoting metastasis and the latter combating tumor growth. This finding opens new avenues for therapeutic strategies to target highly aggressive and therapy-resistant tumors.
Researchers discovered a calcium-based mechanism that aids in disposing of dead cells, shedding light on how bodies protect themselves from injury and disease. The study found that calcium ion levels are essential for efficient removal of dying or apoptotic cells from epithelial tissues.
A research team has successfully recreated wrinkle structures in biological tissue in vitro, revealing the mechanisms behind their formation. The study found that compressive forces and dehydration play a crucial role in wrinkle formation, mirroring aging skin effects.
A team of researchers at UC Davis Health discovered a novel bioelectrical mechanism that allows Salmonella bacteria to navigate the gut lining and find vulnerable entry points. The study found that Salmonella bacteria detect electric signals in FAE, which helps them move towards openings in the gut where they can enter.
A new index uses inflammatory cell proportions to predict tissue healing and outcomes in patients with ulcerative colitis. The index, called the inflammatory cell enumeration index (ICEI), was developed by analyzing data from 220 patients who achieved healing.
A distinct TNF-α signaling program has been identified as a key driver of epithelial cancer development, contributing to cell proliferation and invasion. The researchers found that this program is active in both normal tissues and tumors, but its level of activity correlates with tumor aggressiveness.
The study found that exercise increased PEDF levels in skeletal muscles and suppressed senescence markers in the lungs. PEDF also reduced senescence markers in multiple tissues and attenuated decline in respiratory function in pulmonary emphysema mouse model, suggesting its potential as a therapeutic agent for age-related diseases.
Researchers discuss the critical role of the retinal pigmented epithelium in human vision and its susceptibility to aging. The study highlights the importance of understanding molecular and cellular mechanisms driving age-related pathological changes in vision decline.
Researchers have challenged the conventional view of myriapod ovarian morphology by discovering structural specialization in pill-millipede Hyleoglomeris japonica. The follicle epithelium, previously considered a homogenous structure, exhibits two distinct regions with enhanced and reduced metabolic activities.
Researchers found that cancer cells with multiple mutations alter cell competition, allowing them to infiltrate and form highly invasive tumors. The study identified a key mechanism, MMP21, which promotes the production of diffusely invasive cancer cells.
Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
Researchers have characterised a specialised type of immune cell that plays a key role in protecting and repairing the healthy human gut. Depletion of these cells is linked to inflammatory bowel disease (IBD) progression, with potential implications for treatment options.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
Researchers found that confined epithelial cells regulate their size and cell cycle separately, suppressing growth but not division length. The team used lab-grown tissue to observe how cells respond to confinement, revealing a new framework for understanding tissue development and growth.
Research shows that a diet rich in soluble fiber like inulin can renew intestinal epithelial cells and improve intestinal health. The study found that gut microbiota plays a key role in this process.
A new study by North Carolina State University researchers finds that sucralose-6-acetate, a chemical formed when we digest sucralose, is genotoxic and breaks up DNA. The chemical is also present in trace amounts in the sweetener itself, posing potential health risks.
A new study suggests that high-sugar diets can exacerbate inflammatory bowel disease (IBD) symptoms by disrupting the colon's lining renewal process. The research found that a high-sugar diet led to impaired cell division and altered metabolic pathways in mice, resulting in faster gut damage.
The study, led by Professor Takashi Miura of Kyushu University, has discovered that interdigitated cell boundaries have a mathematically scaling pattern with self-similarity. The team used the Edwards-Wilkinson model to simulate and understand the molecular mechanism responsible for these dynamics.
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Researchers generated a POLDIP2 knockout ARPE-19 cell line and found reduced mitochondrial superoxide levels, consistent with upregulated SOD2. The study demonstrates a potential role of POLDIP2 in regulating oxidative stress in AMD.
Researchers have identified a new cell state in embryonic airway development, which may lead to new approaches for treating chronic respiratory diseases. The discovery highlights the crucial role of cellular heterogeneity in shaping airway biology.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
Engineers create OCTOPUS device to grow organs-in-a-dish, achieving higher levels of maturity than traditional methods. The device allows for more mature organs with complex cell relationships, providing valuable tools for studying human organ development.
Researchers discovered that cephalopods develop their large nervous systems using similar mechanisms as vertebrates, with a focus on the retina. This study provides insight into the developmental process of these intelligent creatures and could lead to new discoveries about human brain development.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
Researchers found microbes influence which genes are used for fat digestion and absorption, leading to changes in epithelial cells. The study also showed microbes promote lipid absorption and impact systemic processes like weight gain.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
Researchers have developed a novel model of the aged lung epithelium in idiopathic pulmonary fibrosis (IPF), a devastating age-related lung disease. The model, which replicates IPF-like changes in mouse cells, holds promise for uncovering new biological mechanisms and testing novel pharmacological compounds to treat the disease.
Researchers at Uppsala University discovered that the surface layer of the intestinal mucosa can contract in response to bacterial attack, preventing damage and promoting healing. This finding offers a potential solution to treating bacterial gut infections, which affect hundreds of millions worldwide.
A simple epithelium modelled as a layer of interconnected polyhedra reveals an inherent mechanical instability that leads to cell extrusion. Small changes in density or topology can trigger extrusion without additional forces, generating forces within the layer that direct further extrusions.
A study led by University of California, Riverside scientists found that thirdhand smoke can damage epithelial cells in the respiratory system by stressing cells and causing them to fight for survival. The researchers identified 382 genes significantly over-expressed and found pathways affected by these genes.
A new study by Monell Center scientists has identified a mysterious sensory cell called microvillous cells (MVCs) that protect the vulnerable olfactory epithelium from viruses and bacteria. These cells may represent potential therapeutic targets to maintain a healthy sense of smell.
Researchers found a newly discovered stem cell that controls the size of the olfactory epithelium's surface area, which regulates its development. This discovery could help explain why dogs have such a superior sense of smell due to their complex turbinate structures.
Researchers have successfully bioengineered a functional lung with perfusable and healthy vasculature in an ex vivo rodent lung. This breakthrough approach selectively treats epithelium while preserving lung vasculature, addressing the organ's extreme complexity.
A study by Thomas Hummel found that the nasal cavity's epithelial lining reacts stronger to inhaled odors, making it easier to detect them. The results suggest that retronasal olfaction, which involves smelling through the mouth, is less sensitive but still allows for a more nuanced experience of food and drinks.
Scientists discovered that regulatory T cells, which calm inflammatory responses, migrate into the gut lining and convert into anti-inflammatory CD4+ cells. The presence of microbes is necessary for this conversion.
Research reveals that gut villification is caused by mechanical compression of the epithelium sheet, rather than active mechanisms involving growth factors. This process involves the spontaneous buckling of the epithelium into longitudinal folds and zigzag patterns, ultimately forming villi.
Researchers found that cells displace due to changing morphogen concentration levels, attracting cells through chemotaxis. This understanding can improve wound healing and artificial tissue engineering.
A study published in Nature reveals that the alignment of the mitotic spindle is essential for maintaining epithelial integrity. The researchers found that when the spindle becomes misaligned, it can cause cells to delaminate from the epithelium, leading to tumor-like growths and expression of genes associated with invasive human tumors.
Researchers have identified a new mechanism by which the bladder senses its level of fullness through integrin proteins. This discovery may lead to the development of new drugs targeting this pathway to treat overactive bladder and incontinence.
Researchers at Huntsman Cancer Institute have discovered that normal epithelium tissue ejects living cells to maintain a steady population and ease overcrowding. This mechanism is crucial in preventing cancer, as it allows cells to turnover and prevents cell pile-ups, which are common in cancerous tissues.
ES cells can differentiate into retinal precursors and form an optic cup-like structure in vitro without external signaling sources. The tissue undergoes a four-step morphological rearrangement to assume the optic cup shape, driven by cell division and epithelial expansion.
Researchers found that patients with flame-like Barrett's epithelium and those with a C extent ≥ 2 cm had higher rates of erosive esophagitis. The study suggests a potential strategy for preventing esophageal adenocarcinoma.
Scientists at University of Illinois successfully convert spermatogonial stem cells into prostate, skin and uterus epithelium using mesenchyme interaction. The approach may provide an alternative to embryonic stem cell use.
A study published in PLoS Medicine found that CD36 deficiency leads to choroidal involution, a key feature of dry age-related macular degeneration. The research also showed that COX-2 down-regulation plays a crucial role in this process.
A study published in Genes and Development reveals a novel molecular player influencing colon cancer initiation. The research found that combining Foxl1 deficiency with an inactive APC gene accelerated tumor formation, highlighting the significance of mesenchymal-epithelial signaling in gastrointestinal tumorigenesis.