Articles tagged with Meninges
A national clinical trial found that abemaciclib, an oral cancer drug, may slow tumor growth in patients with aggressive meningiomas with specific genetic mutations. The trial showed promising results, with a median progression-free survival of 10 months and a median overall survival of 29 months.
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
Researchers have found that psychedelic compounds can reverse a cascade involving brain-resident cells and immune cells, increasing fear behavior when chronic stress disrupts signaling. This finding represents a paradigm shift in understanding psychedelics' therapeutic potential.
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
Researchers at WashU Medicine have found that rejuvenating the network of vessels outside the brain can improve memory in old mice. The study lays the groundwork for developing therapies to overcome the challenges faced by conventional medications, which struggle to reach the brain due to the blood-brain barrier.
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
A mouse model of multiple sclerosis reveals evidence of inflammatory gene expression spilling over from the brain's barrier to grey matter. The study uses spatial transcriptomics to show a gradient of immune genes and inflammatory markers from meninges to surrounding brain tissue.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
Researchers found that dendritic cells in meninges produce mediators causing pain hypersensitivity after nerve injury. The kynurenine pathway, primarily driven by IDO1, is involved in pain production.
A Rutgers study suggests that mucosal-associated invariant T cells (MAITs) protect against cognitive decline by creating antioxidant molecules. Injecting MAITs into genetically altered mice restored their cognitive function, and researchers hope to compare MAIT numbers in healthy humans and those with cognitive diseases like Alzheimer's.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
A new study suggests that a novel treatment involving the administration of an enzyme that degrades neutrophil nets may prevent brain swelling and improve waste clearance in rats with bacterial meningitis. The treatment could be combined with antibiotics if needed.
Researchers found large numbers of B cells and their immature progenitors in the outer layer of the meninges, a surprising discovery that suggests these cells play a special immune system function there. The study used single-cell RNA sequencing to analyze the genes active in each individual cell and confirmed the finding in human tissue.
Researchers at the University of Gothenburg generated a comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, showing that these cells play a crucial role in brain development and pathology. The study also identified novel immune cell subtypes involved in brain injury and provided new insights into the interaction...
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
Researchers discovered that immune cells from the skull bone marrow guard the brain and spinal cord, while others arrive from the bloodstream, carrying genetic signatures that may promote autoimmunity. This finding could inform understanding and treatment of brain disorders such as neuro-COVID, Alzheimer's disease, and multiple sclerosis.
A study in mice confirmed in human samples shows that the brain is protected against infection by immune cells from the gut. The meninges form an impermeable barrier preventing immune cells from entering the brain, but plasma cells secrete antibodies to defend the perimeter of the brain.
Researchers have discovered that gut-educated antibody-producing cells inhabit and defend regions surrounding the central nervous system, including the dura mater. The study shows that these immune cells play a crucial role in protecting the brain against meningitis and other infections.
A new study found that reinforcing the meningeal lymphatic network increases tumor antigen traffic from the meninges to lymph nodes, triggering activation of immune cells against the tumor. This approach combines with existing immunotherapy for effective glioblastoma eradication.
Researchers found that a protein implicated in migraine symptoms caused pain responses only in female rodents, but not males. This discovery may help explain why migraine is three times more common in women than men.
A new NIH study found that meningitis can alter the composition of immune cells in the brain's lining, replacing them with cells from outside the meninges and affecting their ability to respond to future infections. The research suggests that infections in the brain can have long-lasting effects on the immune system.
In a breakthrough study, NIH scientists identified distinct immune cell subsets that work together to repair the damaged meninges and blood vessels in mice. The research provides new insights into the recovery process after concussion and may lead to the development of targeted therapies to improve patient outcomes.
Researchers at Stanford University have observed a cellular response to concussions in mice, revealing how individual cells react to the injury. The study suggests a possible therapeutic approach by using natural antioxidant molecules like glutathione to prevent brain damage.
Researchers at Johns Hopkins Medicine have found the source of migraine pain to be changes within the meninges, the protective tissue layers covering the brain. The study uses SPECT scans to link abnormalities in the meninges with the site of pain.