Articles tagged with Orbitofrontal Cortex
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Researchers found oxytocin release in the orbitofrontal cortex is linked to empathetic responses and stabilizes reciprocal cooperation in rats. Oxytocin-deficient rats exhibited increased 'free-riding' behavior, suggesting a key internal mechanism in cooperative behavior.
A study published in Biological Psychiatry identified the Shisa7 gene as a key driver of heroin addiction. The research team used machine learning to analyze brain tissue from human opioid users and found that modulating this gene's expression influenced heroin-seeking behavior and cognitive flexibility.
A University of Maryland study reveals how the brain adapts to different listening situations, with the orbitofrontal cortex playing a central role. The findings may have implications for human health and well-being, particularly in conditions such as autism, dyslexia, or schizophrenia.
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
Research found a correlation between early negative life events, orbitofrontal cortex thinning, and later depressive symptoms in young adults. A higher burden of negative life events and accelerated thinning of the region were associated with increased depressive symptoms.
A new study found that people with long Covid smell loss have reduced brain activity and impaired communication between key smell-processing regions. This suggests a possible link between smell loss and brain changes, which may be reversible through olfactory training.
Researchers at the University of Calgary discovered a reduction in brain function's brake signal contributes to decisions about eating in obese mice. The study found that when this region is disabled, lean mice continue to overeat despite feeling full.
Researchers found that serotonin release in these areas increases waiting time, particularly when reward timing is uncertain. A computational model explains the mice's behavior by predicting reward delivery timing and estimating probability.
Researchers found that the orbitofrontal cortex, responsible for calculating economic value, also judges relationship value based on commitment signals. This suggests a neural overlap between economic and social value evaluation.
A team of scientists created a map highlighting the brain circuits affected in mania, which could lead to more effective treatments for bipolar disorder. The study identified specific regions, including the orbitofrontal cortex and inferior temporal cortex, as key players in mood regulation and emotional processing.
Rats' brain activity shows that individual preferences for alcohol vary based on how the brain interprets it as a reward. The orbitofrontal cortex stores reward value and regulates reward seeking, with malfunctioning linked to drug use disorders.
A UC Berkeley study reveals the brain's orbitofrontal cortex replays and revisits nearly every feature of previous decisions after placing a bet. The researchers found that gamblers' regret from losing or not betting more is the main driver of activity in this region.
Researchers discovered that brain's midbrain encodes errors in identity expectations, updating frontal lobe for decision-making. Dopamine neurons likely involved in encoding these errors.
A team of researchers has identified five subareas in the prefrontal cortex that play key roles in decision-making processes related to movement. By deactivating specific brain regions using optogenetics, the study found that inhibition and excitation areas work together to regulate movement. These findings have implications for unders...
Depression affects the lateral orbitofrontal cortex, leading to feelings of loss and disappointment. Reduced connectivity between reward and memory systems may also contribute to negative thoughts. The study provides new insights into depression's root cause, potentially leading to breakthroughs in treatment.
A new study provides direct evidence of the brain's navigation network, including the orbitofrontal cortex and frontopolar cortex. The research found that these regions play key roles in classifying future goals and visualizing spatial contexts for navigation.
A new analysis found that healthy adults with larger orbitofrontal cortices tend to be more optimistic and less anxious. The study suggests that a thicker OFC may act as a buffer against anxiety by boosting optimism, and that increasing optimism can reduce anxiety.
A study found that obese individuals' brains show different connectivity patterns when craving food compared to normal-weight individuals. The researchers discovered a link between increased brain activity and weight gain in obese subjects.
Researchers discovered a new pathway in the brain's striatum where several areas communicate to make spatial decisions, such as estimating where to swing a bat or finding a car. This knowledge may lead to improved treatments for Parkinson's disease by strengthening damaged pathways.
A new study found that gamblers' brains exhibit similar increases in theta activity to wins and near-misses, particularly in the insula and orbitofrontal cortex. This response is associated with gambling severity and susceptibility to problem gambling. The research suggests that brain responses to near-misses resemble those to actual w...
Research found that teens with anorexia nervosa had larger insula and orbitofrontal cortex brain areas, which may contribute to their ability to starve themselves. These brain regions process taste and body perception, potentially leading to a distorted sense of hunger and fullness.
Researchers found that the lateral and orbital regions of the frontal cortex interact during drug-related cues, suggesting that addiction may result from abnormal brain circuitry. The study's findings suggest that a therapeutic approach for addiction could be developed by targeting this neural circuit.
A new study from the University of Maryland School of Medicine has identified the orbitofrontal cortex as a critical brain area involved in value-guided behavior, decision-making, and learning. The research suggests that damage to this area can lead to decreased ability to use prior experience to make good decisions.
A new study published in Cortex found that the orbitofrontal cortex plays a central role in an event monitoring system, which allows us to adapt to unexpected events. The brain's response to anticipated and unexpected outcomes is influenced by the potential harm of the outcome.
A new study finds that smoking is associated with reduced cortical thickness in the left medial orbitofrontal cortex, negatively correlating with cigarette consumption. Heavier smoking was linked to more pronounced thinning of cortical tissue, potentially increasing the risk for addictions and cognitive decline.
A study of smokers and non-smokers found that smokers have a thinner cerebral cortex, specifically in the medial orbito-frontal region. This region is crucial for reward, impulse control, and decision-making. Further research is needed to determine if smoking causes or contributes to this brain structure change.
Researchers at the University of Pittsburgh have identified the orbitofrontal cortex as a promising target for developing new antipsychotic drugs to treat schizophrenia. The study found that this brain region responds to both dopamine and glutamate, neurotransmitters linked to schizophrenia.
Research published in PLOS ONE found that the medial orbitofrontal cortex is highly specifically active within a seventh of a second in response to infant faces but not to adult faces. This finding has potentially important clinical application in relation to postnatal depression.
A brain imaging study found that a specific gene variant associated with Alzheimer's disease is linked to thinner brain structures in youth, which may increase the risk of mental decline. The ApoE4 variant affects learning and memory hubs, but its impact on intellectual ability appears harmless.
A study published in the SLEEP journal found that brain areas hyperactivated during cataplexy in a narcoleptic patient resemble those active during normal REM sleep, but without other characteristic features. This discovery may help explain how narcolepsy's cataplexy symptom occurs.
A new study by Northwestern University researchers shows that the brain learns to differentiate between similar smells simply through passive experience. Prolonged sensory exposure induces 'expertise' in specific smell categories, leading to improved odor discrimination and retention of this expertise for at least 24 hours.
Research suggests that sexual orientation influences how people perceive individual faces, particularly in the brain's reward circuitry. The study found that heterosexual women and homosexual men responded more strongly to male faces, while heterosexual men and homosexual women responded more to female faces.
Researchers found that mothers' brain activity increased when shown pictures of their own babies compared to others, indicating involvement of the orbitofrontal cortex in maternal attachment. The study's findings suggest a link between positive emotions and maternal bonding.
Researchers have directly observed the brain mechanisms involved in predictive associations, a key process in associative learning. The study found that changes in neural activity in the amygdala support changes in the orbitofrontal cortex, highlighting the importance of this brain system.
Researchers discovered that the brain can associate certain stimuli with food consumption when hungry, but not after eating. This association is linked to brain regions involved in conditioning and reward pathways.
A study found that depressed patients' brains respond differently to smells and visual stimuli compared to healthy individuals. The researchers suggest that alterations in the orbitofrontal cortex and amygdala may contribute to the reduced sense of smell and intensified emotions in depression.
Researchers used PET scans to explore brain activity while watching actors tell stories with sad and neutral tones. The study found that brain regions associated with emotional processing were activated when the story content and actor's expression matched, but suppressed when they didn't.
A new study finds that methamphetamine abusers have fewer dopamine receptors, leading to reduced motivation and drive. The study suggests that the drug's high dopamine release overactivates the brain's reward system, making it hard for addicts to resist.