Articles tagged with Peripheral Blood Mononuclear Cells
Researchers have developed a nondestructive imaging technique to measure single-cell immune metabolism in real patient blood samples, providing a higher level of information than current clinical techniques. This breakthrough could improve disease diagnosis and treatment for conditions like blood cancers, lupus, and sepsis.
Researchers mapped over 1.25 million cells to reveal sex-specific differences in the human immune system. Female immune cells exhibit higher levels of B cells and regulatory T cells, but also a greater predisposition to autoimmune diseases like lupus due to their highly reactive profile.
Researchers have developed a blood test that detects Parkinson's disease by analyzing the activity of immune cells. The study found 22 genes whose expression was altered in patients with Parkinson's, suggesting potential diagnostic markers and insights into the disease's mechanisms.
Researchers from the University of Cincinnati Cancer Center presented abstracts highlighting contrasting effects of a protein on head and neck, breast, and lung cancers. The study found increased levels of IL-9 in patients with head and neck cancer correlated with decreased survival, while elevated IL-9 was associated with smaller tumo...
Researchers have developed nanodrones that target and eliminate cancer cells by recruiting natural killer cells to tumor sites. The study offers a potential solution for intractable types of cancers, with promising results in suppressing tumor growth without causing side effects.
Researchers have developed a microfluidic squeezing technology that stimulates anti-tumor activity in a subtype of HPV16-positive head and neck, cervical, and anal cancers. The treatment uses peripheral blood mononuclear cells trained to recognize and attack cancer cells without genetic modifications.
A new study by researchers at Florida Atlantic University explored the effects of resistance training on older adults' cellular level. The study found that resistance training did not significantly affect inflammatory proteins or redox balance markers, but showed a significant reduction in a specific protein ratio. This may support the...
Researchers found that CD4+ T lymphocytes — immune system cells — produced by people who received COVID-19 vaccines persisted at high levels six months after vaccination, with a significant response against the delta variant. The study also showed that vaccine-elicited fighters recognize and help attack coronavirus delta variant.
A Russian scientist has received funding to analyze the tumor microenvironment and develop new cancer therapies. The project aims to create targeted treatments with minimal side effects, building on gene and cell technologies.
The new assay enables simultaneous measurement of tirabrutinib bound and total BTK levels, reducing sample requirements. It uses full-length purified recombinant human BTK protein and PBMCs derived from healthy volunteers and patients with CLL, demonstrating its utility for pharmacodynamic assessments.
Research suggests that night shift work can disrupt human circadian rhythms, leading to gene expression changes and immune system dysregulation. The study's findings highlight the potential risks of long-term night shift work on human health, particularly in relation to medical disorders such as diabetes and cancer.
Researchers found that shorter telomere lengths in certain cells are associated with an increased risk of developing upper respiratory infections. The study, published in JAMA, suggests a link between telomere shortening and immune system dysfunction in younger, healthy populations.
Researchers found that the human gut stores a significant amount of HIV, equivalent to nearly twice the amount in the bloodstream. The gut's role in harboring the virus was not fully understood until now.