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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

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Chlamydiae expand our view on how intracellular bacteria evolve

Researchers at the University of Vienna and Wageningen University & Research found that chlamydiae, which live inside host cells, evolved over a billion years ago. They also discovered that some chlamydiae gained important genes through gene transfer from other bacteria, challenging traditional views on endosymbiotic evolution.

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Saving kids from dangerous infections -- with an amoeba

A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.

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Improving the treatment of periodontitis

A study by Charité - Universitätsmedizin Berlin reveals that the amoeba Entamoeba gingivalis plays a key role in periodontitis, causing inflammation and tissue destruction. The parasite's elimination may improve treatment outcomes for patients with gum disease.

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Amoeba builds barriers for protection against bacteria

Researchers at Baylor College of Medicine discovered that amoebae build a barrier around their colonies to counteract bacterial attacks. The protein CadA enables the amoebae to recognize specific species and adapt to survive, forming clumps with Gram-negative bacteria and allowing for feeding on the edges.

A petrifying virus key to evolution

A newly discovered Medusavirus giant virus provides new insights into host-virus co-evolution, with features including DNA coding for five histones and unique capsid surface proteins. The discovery suggests a lateral gene transfer model between host and virus.

How the cholera bacterium survives water predators

The Vibrio cholerae bacterium has evolved skills to survive in aquatic environments by 'hitchhiking' on predatory amoebas and establishing a replication niche within their osmoregulatory organelle. This adaptation may have contributed to the emergence of V. cholerae as a major human pathogen.

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Lectins help social amoeba establish their own microbiome

Researchers at Baylor College of Medicine discovered that sugar-binding proteins called lectins are essential for social amoebas and bacteria living together. Lectins protect bacteria from being killed by amoebas and mediate the establishment of a microbiome, allowing bacteria to transfer genetic material to the amoeba.

Bacteria stab amoebae with micro-daggers

Researchers at ETH Zurich have discovered a mechanism used by bacteria Amoebophilus to shoot micro-daggers that pierce the digestive compartment of an amoeba, allowing it to escape digestion and thrive. The study reveals new insights into bacterial evolution and opens up possibilities for other structural biology investigations.

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How many protozoa are in the water we drink?

A study by the University of Zaragoza found Giardia and Cryptosporidium in 55% and 70% of drinking water plants, posing a public health risk despite low concentrations. The pathogens are resistant to chlorination and can trigger diarrheic outbreaks.

Study finds amoeba 'grazing,' killing bacteria usually protected by fi

A University of Wisconsin-Madison study reveals that certain amoebas called dictyostelids can penetrate biofilms and devour bacteria, including multi-drug resistant species. This finding has potential applications in combating antibiotic-resistant infections, such as bacterial keratitis and fire blight.

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This little amoeba committed grand theft

Researchers have solved the mystery of how Paulinella, an amoeba, engulfed a bacterium and harnessed its genes for photosynthesis. The study reveals that microbial genomes can move genes between organisms according to need, and that this process allows for adaptation and evolution.

Prestigious Pew scholarship for amoeba 'cell nibbling'

Dr. Katherine Ralston, a UC Davis microbiologist, has been awarded a 2016 Pew scholarship to study the mechanisms of 'trogocytosis,' or 'cell nibbling,' which allows Entamoeba histolytica to kill cells in the human intestine. This research could lead to new insights into disease prevention.

Farming amoebae carry around detoxifying food

Research reveals that social amoeba Dictyostelium discoideum relies on its symbiotic bacteria to protect itself from environmental toxins, despite having fewer detoxifying sentinel cells. The bacteria help shield the amoebae from toxins, enabling them to thrive even in toxic environments.

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DNA as a weapon of immune defense

Scientists have found that a social amoeba uses both phagocytosis and DNA nets to defend against bacteria, similar to the human immune system. This discovery could lead to new treatments for chronic granulomatous disease and other immune disorders.

Understanding how cells follow electric fields

Researchers at UC Davis identified genes linked to electrotaxis in amoebas, which could help understand electrical signals detection. The study's findings may lead to new insights into wound healing and tissue development.

Findings reveal clues to functioning of mysterious 'mimivirus'

Researchers have discovered the structure of a key protein on the surface of the mimivirus, aiding efforts to determine its hosts and unknown functions. The R135 protein is similar to an enzyme found in a fungus and may participate in biodegrading lignin, suggesting alternative hosts such as algae.

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Why slimy cheats don't win

A team of scientists found that cheater amoebae produce fewer high-quality spores, which survive better, suggesting a more balanced system than previously thought. This discovery has implications for developing therapies using socially successful bacteria to fight diseases.

How cells know which way to go

Two new studies from Johns Hopkins shed light on how complex cells detect and respond to minute differences in chemical concentrations. Cells use their internal 'skeleton' to influence gradient detection and movement, with implications for development, immune response, wound healing, and cancer metastasis.

Diseases of another kind

A new paper by UCSB researchers scrutinizes Naegleria fowleri, a heat-loving amoeba causing rare but fatal infections. The study highlights the distinction between sapronotic diseases and conventional infectious diseases.

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Model organism gone wild

Scientists studying the wild strain of the model organism Dictyostelium discoideum discovered that some clones can farm bacteria and carry defensive symbionts to protect their crops. The researchers isolated wild clones from soil and found that these clones were more complex than previously thought.

Genes define the interaction of social amoeba and bacteria

Researchers identified genetic controls that enable social amoebas to differentiate between gram-negative and gram-positive bacteria. The study found nearly 800 genes activated when exposed to gram-negative bacteria, highlighting a key role for a specific gene in degrading bacterial cell walls.

Profiting from climate change

Researchers found that tiny single-cell organisms are spreading rapidly through the world's oceans, stabilizing coastlines and reefs with their calcareous shells. By 2100, these protozoa may spread closer to the poles, occupying ecological niches left by corals.

Close family ties keep microbial cheaters in check, study finds

Experiments with social amoebae reveal that cooperation depends on kinship, and population bottlenecks can stabilize cellular cooperation. The study found that nearly all multicellular organisms begin life as a single cell, and that cheater mutants are more likely to occur in groups where relatedness is low.

Social amoeba rely on genetic 'lock and key' to identify kin

Researchers at Baylor College of Medicine identified a genetic 'lock and key' mechanism in social amoebae that enables cells to recognize kin from non-kin. The proteins TgrB1 and TgrC1, with immunoglobulin folds, act as a lock and key, facilitating cooperation and aggregation among genetically similar cells.

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Tiny protozoa may hold key to world water safety

A new technology using tiny protozoa to detect toxins in water sources may provide unprecedented assessment of the world's water supplies. The Swimming Behavioral Spectrophotometer (SBS) can detect chemicals, pesticides, and biological warfare agents with near-instant feedback.

In amoeba world, cheating doesn't pay

In a study published in Nature, researchers found that cooperative amoebas can evolve genetic defenses against cheaters, preserving collective behavior. The Dictyostelium discoideum mutants discovered by the Rice-Baylor team demonstrated a remarkable ability to resist cheater cells and maintain altruistic traits.

Discovery in amber reveals ancient biology of termites

The analysis of a 100-million-year-old termite in amber has revealed the oldest example of mutualism between an animal and microorganism, showing that termites depend on protozoa to digest wood. The study also found new fossil flagellate species, a new species of termite, and other discoveries.

Study shows how Salmonella survives in environment

Scientists have discovered that Salmonella uses a secretion system to protect itself inside amoeba, allowing it to survive and multiply. This finding has significant implications for controlling the spread of Salmonella in water supplied to animals.

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Ameobas: Keeping it in the family

In a breakthrough study, researchers discovered that social amoebas form multi-cellular organisms with genetically similar 'kin' to ensure survival. By aggregating based on genetic similarity rather than true kinship, cells can increase their chances of reproducing and passing on their genes.

Protein compass guides amoebas toward their prey

Researchers at the University of California, San Diego, discovered a protein compass that helps amoebas find bacteria by scent. This molecular switch is also shared with human immune cells to locate infection sites.

How Montezuma gets his revenge

Researchers found a new enzyme, EhROM1, that helps the dysentery-causing amoeba evade the immune system. The enzyme is part of an ancient group of enzymes used by malaria parasites to enter host cells.

DNA analysis shows true dispersal of protozoa

A study published in BMC Evolutionary Biology found that some protozoa are globally dispersed, while others are geographically restricted, suggesting a moderate degree of endemicity. The analysis used a new fast-evolving DNA marker to reveal higher biodiversity than previously thought.

Immunity in social amoeba suggests ancient beginnings

The discovery of an immune system in a social amoeba suggests that multicellularity may have originated from ancient signaling mechanisms. The study identifies a 'sentinel' cell that circulates within the slug, eliminating bacteria and toxins through a Toll/Interleukin-1 Receptor domain protein pathway.

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Scientists' cell discovery unearths evolutionary clues

Researchers have produced the first molecular 'dictionary' of social amoeba species, revealing a major trend in the evolution of increased cell specialization and organism size. The study provides a powerful tool to examine molecular mechanisms driving evolution and development.

MRSA use amoeba to spread, new research shows

MRSA has been found to infect a species of amoeba, which can help the bacteria spread between locations. This discovery raises concerns about hospital hygiene and the potential for MRSA to emerge more resistant to antibiotics and virulent.

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Social amoeba sheds light on communication in human brain

A study published in PNAS reveals a short protein, SDF-2, used by Dictyostelium to synchronize spore formation, similar to DBI found in human brains. The discovery confirms the organism's potential as an experimental system for studying cell communication.

Genome of social amoeba shows its importance as research model

The sequencing of Dictyostelium's genome has clarified its relationship to humans, revealing nearly twice as many protein coding genes as fungi. This increase in gene function information makes it a more effective model for discovering targets for drugs against human diseases.

Cancer-suppressing protein is part of amoeba's compass

PTEN, a cancer-suppressing protein, directs cells by anchoring to the cell membrane and regulating phosphate groups. Its presence helps cells move forward while restricting movement at the back, crucial for sensing direction. The findings could have implications in understanding cancer spread and metastasis.

Movement of single molecules imaged in live organism

Researchers successfully imaged single molecules of cAMP binding to receptors on the surface of living amoebae, providing new insights into chemotaxis and cell movement. The study's real-time video reveals how receptors behave when detecting cAMP gradients, allowing cells to respond faster to changes in their environment.

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