Articles tagged with Salivary Glands
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A recent study published in JAMA Otolaryngology–Head & Neck Surgery found an association between cannabis use disorder and benign salivary gland tumors. The researchers call for further prospective research to confirm this association and understand the relationship between cannabis use and these tumors.
A patient with adenoid cystic carcinoma was successfully treated with step-and-shoot proton arc therapy at Corewell Health William Beaumont University Hospital. The treatment showed minimal side effects, including only light skin discoloration, and the patient remains cancer-free.
A natural citrus oil, when combined with a lipid formulation, may effectively relieve dry mouth in cancer patients. The new formula has demonstrated improved solubility and bioavailability compared to pure limonene.
New discoveries by NYU researchers find that impaired regulatory T cells are a key contributor to Sjögren's disease in both mice and humans. Calcium signaling also plays a crucial role in the development of the autoimmune disorder, which affects glands producing saliva and tears.
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Researchers studied how viruses move proteins in fruit flies to infect other animals. They found that viral proteins have built-in GPS signals guiding them to precise locations within the host cells. This knowledge could lead to new strategies for disrupting virus movement and controlling insect-borne diseases.
Patients with Parkinson's disease exhibiting sympathetic denervation in major salivary glands and the heart tend to have more advanced non-motor symptoms as they age. Autonomic nerve dysfunction may progress independently of nigrostriatal dopaminergic degeneration, suggesting a potential contribution of age to PD progression.
Seven high-impact studies will be showcased, exploring novel therapies and improving treatment outcomes for patients with head and neck squamous cell carcinoma. These findings highlight advancements in immunotherapy, risk-directed adjuvant therapy, and FDG-PET-based selective de-escalation of radiotherapy.
Researchers highlight the need for effective treatment strategies for adenoid cystic carcinoma (ACC) of the head and neck, which is a highly malignant tumor with variable localizations. Proton therapy shows decisive advantages in long-term survival rates for ACC.
This study examined the effects of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. The researchers found that these compounds reduced inflammation, fibrosis, and improved salivary gland function, suggesting potential treatments for postmenopausal xerostomia.
A new PSMA PET scoring system, the tumor-to-salivary gland ratio (PSG score), can predict patient response to <sup> 177 </sup> Lu-PSMA therapy. Patients with high PSG scores had longer PSA progression-free survival and overall survival rates.
A USC-led team of scientists identified the key gene Nr5a2, essential for opening up genome regions that enable neural crest cells to form tendons and salivary glands. Zebrafish and mice lacking this gene exhibited skeletal and tendon defects, as well as failed salivary gland development.
In a groundbreaking study, researchers at Eötvös Loránd University have found that gland cells in Drosophila melanogaster can remove defective secretory particles as early as the secretion process begins. This discovery sheds new light on crinophagy, a previously understudied process crucial for maintaining cellular quality and function.
Researchers found that activating the non-mutated form of P53 can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma. This new therapy approach shows promise for treating this lethal form of salivary gland cancer.
Exosomes have been identified as possible vehicles for virus transmission, and a recent study found that the saliva protein exportin 6 plays a crucial role in this process. The researchers isolated exosomes from the saliva of insect vectors and showed that they can transport plant virions into rice plants.
Researchers found enteric viruses like noroviruses replicate in the salivary glands of mice and can be transmitted through their saliva, potentially explaining high infection rates worldwide. This discovery could lead to new prevention and treatment strategies for diseases caused by these viruses.
Scripps Research scientists have discovered a special cell type called 'ionocyte' that maintains healthy concentrations of ions in saliva, producing growth factor FGF10. This ionocyte might hold the key to repairing salivary glands and treating conditions like Sjögren's syndrome and dry mouth.
A new chewing gum infused with plant-grown ACE2 protein can neutralize the SARS-CoV-2 virus in saliva, potentially reducing transmission risk. The gum, developed by researchers at the University of Pennsylvania, was tested on saliva samples from COVID-19 patients and found to significantly reduce viral load.
Researchers will explore ways to regenerate damaged salivary glands and understand vocal fold scarring, aiming to develop new treatment options for head and neck cancer patients. The project includes creating a vocal-fold-on-a-chip model with embedded sensor technology to monitor tissue development in real-time.
Researchers identified cell diversity in embryonic salivary glands through single-cell transcriptome analyses, revealing early establishment of transcriptional identities. The study provides comprehensive descriptions of molecular signatures defining specific cellular landmarks.
Sarah Knox is recognized for her outstanding contributions to salivary research, with a focus on parasympathetic innervation and tubulogenesis in developing salivary glands. Her work has elucidated mechanisms of salivary gland development and regeneration relevant to tissue repair in autoimmune disease and cancer.
Researchers at the University of São Paulo discovered that SARS-CoV-2 infects and replicates in salivary glands, leading to high viral loads in saliva. The study suggests that tissues specializing in saliva production serve as reservoirs for the virus.
A study found that COVID-19 survivors experienced frequent and persistent salivary gland ectasia and oral disease, with 83.9% of patients displaying signs of salivary gland ectasia. The study suggests a strong link between SARS-CoV-2 infection and oral disorders.
A new paper in Cell Reports breaks down the details of how salivary glands collectively produce proteins found in saliva. The study identifies which proteins are produced by each type of gland and shows that individual cells within a single gland can secrete different proteins.
Scientists discover two compounds that can dry up tick saliva, reducing feeding and potentially limiting pathogen transmission. The treatment effectively kills ticks within 12 hours, a significant timeframe for pathogen transmission.
A study reveals that mosquitoes' salivary glands contain a barrier that blocks most malaria-causing parasites from being transmitted during a bite. Researchers found that only a few parasites can pass through a narrow opening in the 'chitin wall', potentially leading to new strategies for preventing malarial infection.
Researchers identified a translocation between chromosomes 4 and 9 in acinic cell carcinomas, leading to the activation of oncogenic genes. This discovery sheds light on the molecular causes of salivary gland cancer, enabling easier diagnosis and potentially new treatment options.
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) have discovered that flaviviruses reproduce in specific locations within tick salivary gland cultures. This finding could explain why virus transmission occurs so quickly, and may help identify transmission pathways that can be blocked with a countermeasure.
Scientists successfully grew three-dimensional salivary gland tissue that produced saliva in mice, paving the way for potential treatments for patients with failing organs. The research used embryonic stem cells to create an organoid, a simplified three-dimensional tissue that resembles a real organ.
New research published in Frontiers in Microbiology finds that higher temperatures and temperature fluctuations accelerate the growth of the dengue virus in mosquitoes, making them more infectious. This could help prevent outbreaks during warm periods by reducing mosquito numbers or controlling exposure.
Researchers found that transient activation of the Hedgehog pathway after irradiation rescued salivary gland dysfunction by preserving stem/progenitor cells and parasympathetic innervation. Shh gene transfer improved saliva flow rates in mice, while also preserving acini marker Aqp5 expression.
Scientists have developed a novel process to regenerate salivary cells using silk fibers as a framework, which could help millions in the US with dry mouth due to Sjögren's syndrome. The process has been shown to retain salivary gland cell properties and is a significant step towards developing new cell-based therapeutics.
A team of researchers aims to grow whole salivary glands using patient's own cells to replace those destroyed by cancer radiation therapy, benefiting thousands of cancer patients with dry mouth. The regenerative method could also help those with Sjögren's syndrome, a chronic disease that affects moisture-producing glands.
The University of Delaware is part of a $2.5 million NIH-funded project to create artificial salivary glands. Researchers hope to develop new solutions for Xerostomia, a side effect of radiation treatment for head and neck cancers. The project involves developing hydrogels that can guide salivary cells to form functional glands.
Researchers found that dengue virus infection of mosquito salivary glands triggered genes involved in immune response, feeding behavior, and odor sensing. This may facilitate the spread of dengue fever to humans by making mosquitoes more efficient at finding and feeding on hosts.
A recent study found that dengue virus infection triggers changes in the activity of genes and functions of mosquito salivary glands, which may lead to greater virus transmission. The researchers also identified three salivary gland genes that modulate dengue virus infection and two olfactory genes that help control mosquito behavior.
Researchers confirm cytomegalovirus as a cause of common salivary gland cancers, with implications for human health. The study suggests CMV's role in cancer development and potential new prevention and treatment methods.
Researchers at University of Louisville identified a protein sorting mechanism used by the salivary gland, which could lead to advanced therapies for patients with damaged or non-functioning salivary glands. The study found that a specific lipid molecule, PtdIns(3,4)P2, plays a crucial role in sorting proteins into vesicles for secretion.
Researchers found that vaccinating through salivary glands can provide protection against various diseases, including influenza and cholera. The technique involves administering vaccines directly into the salivary glands, which then trigger an immune response both locally and systemically.
Scientists at the University of Connecticut Health Center have visualized the movement of Lyme disease-causing microbes within feeding ticks. The study found that these microbes undergo a biphasic mode of dissemination, first forming networks of nonmotile organisms and then becoming motile invasive organisms.
Professor Alessandro Riva, a leading expert in human exocrine glands, has made significant contributions to the understanding of salivary gland structure and function. He established benchmarks for the field through his published work, which includes numerous original observations and unique methods.
Researchers at Johns Hopkins Malaria Research Institute identified saglin and TRAP as essential proteins for Plasmodium's invasion of the Anopheles mosquito salivary gland, a critical step in transmitting malaria to humans. This discovery could lead to novel approaches for disrupting the parasite's lifecycle and preventing malaria spread.
Scientists have discovered condensin II, a protein that separates chromosomes by twisting them into supercoils, enabling proper chromosome alignment and gene expression. This breakthrough could lead to better understanding of genetic disorders like Down syndrome and improved DNA sequencing analysis.
Researchers found that green tea's EGCG reduced salivary gland damage and delayed insulin-dependent type 1 diabetes in a laboratory mouse. The study also showed that EGCG suppressed abnormal gene expression and lowered serum autoantibodies, reducing Sjogren's syndrome-like symptoms.
A University of South Florida study found that protein MAEBL is essential for malaria parasites to invade mosquito salivary glands, allowing transmission to humans. By silencing the receptor for MAEBL, researchers hope to block passage of the parasite through mosquitoes.
The study found that endothelin, a protein regulating blood pressure, directs nerve cell growth along specific blood vessel branches. In mice, nerve cells grown near endothelin-soaked beads or in the absence of endothelin failed to grow towards those areas.
Researchers at La Jolla Institute for Allergy & Immunology have made an important finding on cytomegalovirus transmission by reducing the virus in salivary glands using antibodies. The study may have implications for other chronic virus infections like hepatitis and HIV.
Dr. Arthur R. Hand is recognized for his significant work on salivary gland ultrastructure and function, including the role of cyclic-AMP-dependent protein kinase and lingual lipase and amylase. He has made major contributions to our understanding of salivary glands and their various components.
Dr. Bruce J. Baum is recognized for his significant contributions to oral medicine and pathology, including the discovery of xerostomia's importance in clinical practice. His research has led to the development of novel treatments for salivary gland damage and single-protein-deficiency disorders.
Targeted overexpression of HSP25 protects salivary gland function by maintaining gland weight, salivary flow rate, and salivary fluid composition. HSP25 also preserves expression of aquaporin 5, crucial for water transport in salivary glands. These findings suggest a novel radioprotective strategy against radiation-induced salivary gla...
Researchers discovered that the protein CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland, improving understanding of how cells become specialized for secretion. This finding could potentially help fix problems with pancreatic cells in juvenile (type I) diabetes.
Researchers developed a genetically altered mouse model for Sjögren's syndrome, a rare autoimmune disorder affecting 0.6 percent of the population. The Id3-deficient mice exhibited reduced tear and saliva secretion, lymphocyte infiltration, and autoantibody production, mirroring human disease characteristics.
In a groundbreaking study, researchers identified the 'reaper' genes as critical components of cell death in Drosophila. The discovery opens doors to developing targeted cancer treatments by unleashing death-inducing genes specifically at unwanted cells. Ecdysone plays a crucial role in triggering this process.
Professor Ekström received the IADR Salivary Research Award for his pioneering work on non-conventional transmitters in salivary glandular function. His research has significantly advanced our understanding of autonomic neurotransmission mechanisms and their effects on salivary secretion.
Researchers discovered that the alternative outer surface protein OspC facilitates Borrelia burgdorferi's invasion of tick salivary glands. Inhibiting OspC with antibodies can prevent B. burgdorferi from invading and transmitting to new hosts, offering a potential approach to reducing Lyme disease incidence.
Researchers at Yale University demonstrate that OspC is critical for Borrelia burgdorferi's ability to invade tick salivary glands and be transmitted to humans. Meanwhile, studies on hereditary spastic paraplegia and idiopathic pulmonary fibrosis reveal potential new targets for treatment.
Researchers have successfully used gene therapy to trigger saliva production in rats with damaged salivary glands, a condition similar to that experienced by head and neck cancer patients. The treatment involves infecting ductal cells with an adenovirus carrying the aquaporin gene, which allows them to produce fluid and secrete saliva.