Articles tagged with Transmissible Spongiform Encephalopathy
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Davis Joseph's groundbreaking discovery identifies a common master switch that can cure multiple brain-related diseases with a single method. The unified theory establishes that regulating axon-based 4E-BP2 protein deamidation can control disease progression.
Researchers have developed new models to explore the role of a membrane anchor on the folding and aggregation of PrP. Anchoring stabilizes folding and inhibits aggregation, with clumping induced by pre-formed aggregates, suggesting a potential mechanism for infectious prion diseases.
Researchers found that Florida panthers are not at increased risk for contracting chronic wasting disease from eating infected deer. The study provides relief to conservation efforts, as the disease has spread through North America's deer and elk populations.
Researchers developed a new visual diagnostic technique called Cap-QuIC that can distinguish infected samples with the naked eye, enabling faster and more accurate disease detection. The method builds upon previous groundbreaking diagnostic techniques and leverages simple action to detect misfolded alpha-synuclein proteins.
A new study from the University of Pennsylvania School of Veterinary Medicine sheds light on how Chronic Wasting Disease (CWD) impacts the gut microbiome, providing a potential tool for disease surveillance. Researchers found that certain types of gut bacteria can differentiate between CWD-positive and -negative deer.
Researchers at the University of Wisconsin-Madison found that ticks can harbor transmissible amounts of the protein particle causing CWD, potentially spreading the disease between deer. The study also suggests that better land stewardship and tick management could help manage CWD populations.
Researchers at the University of Pennsylvania's Working Dog Center trained dogs to distinguish between healthy and diseased deer feces. The dogs showed great specificity in detecting CWD-positive samples, suggesting a potential asset in managing the highly contagious disease.
Researchers have found evidence of genetic diversity in the prion protein gene of endangered Eld's deer, which could provide resistance to chronic wasting disease. The study suggests reducing the frequency of a variant associated with the disease and implementing strict management practices to prevent exposure.
A new study reveals the molecular mechanism that causes prion proteins to take on their pathological form, paving the way for possible therapeutic options. The discovery highlights the structure of the human prion protein and its intermediate forms, enabling the design of new organic molecules to block disease progression.
Case Western Reserve University researchers have identified structural elements on human prions that drive their replication in the brain. This breakthrough could lead to a new strategy to stop Alzheimer's disease and other neurodegenerative disorders, as scientists explore ways to bind to these sites to block progression.
Researchers analyzed data from GPS radio collars on over 600 deer in Missouri to discover an adult white-tailed deer traveled 300 kilometers in 22 days. The finding has important implications for population management and disease transmission, particularly chronic wasting disease.
A new study by researchers at the University of Michigan and University of Pennsylvania indicates that individuals disproportionately find polls more credible when their preferred candidate is leading. The study suggests that emphasizing polls' methodological quality can lessen voters' biases, potentially benefiting democracy.
A team of scientists has developed a synthetic-molecule-based approach to isolate prion proteins in body fluids, paving the way for quick, noninvasive detection. The test also detects misfolded proteins associated with Alzheimer's and Parkinson's diseases.
A new study by NIH scientists found that a 40% household bleach solution can inactivate chronic wasting disease prions within 5 minutes, providing a potential method for decontaminating hunting and meat processing equipment.
Researchers identified a panel of genetic markers that reliably predict which animals are most vulnerable to chronic wasting disease in Northeastern deer. The study found that deer with the more susceptible genotypes are in the majority, particularly in the Mid-Atlantic region where an outbreak is occurring.
Scientists discovered that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. Microglia might delay disease progression, providing new insights into inherited photoreceptor degeneration diseases.
A major soil organic matter compound, humic acid, has been found to degrade chronic wasting disease prions and reduce their infectivity in mice. The findings suggest that soil organic material can break down the prions, making them less infectious.
New research reveals that not all prion strain combinations result in interference, suggesting greater strain diversity than previously thought. The study found that co-infecting strains amplify independently, changing the paradigm of prion strain interactions and implications for interspecies transmission.
Researchers discovered that microglia can defend against prion infections by trapping and destroying aggregated prion proteins. Eliminating microglia with a specific drug accelerated disease progression in infected mice. The findings suggest targeting microglia to slow the course of prion diseases, including Alzheimer's and Parkinson's.
Researchers developed a rapid test to diagnose Parkinson's and dementia with Lewy bodies using cerebral spinal fluid samples. The test showed high accuracy in detecting these diseases within two days, outperforming related assays.
Researchers found that soils with more than 18% clay are associated with a steep drop in cases of chronic wasting disease. Additionally, soils with pH above 6.6 also show higher incidence rates of the disease. These findings could inform future management schemes to prevent disease transmission.
A recent study has discovered an unexpected link between Parkinson's disease and prion diseases, revealing a complex interaction between α-synuclein and the prion protein. The findings suggest that α-synuclein deposits in brain cells can slow the progression of prion diseases.
Researchers at Michigan State University have discovered that altering pH levels can prevent prion proteins from aggregating and forming deadly diseases. The study used a laser technique to measure the speed at which proteins rearrange before clumping, and found that an antihistamine called astemizole was effective in reducing prion ag...
Researchers tracked white-tailed deer east of Casper for eight years, finding that CWD drastically reduced annual survival rates, especially in females. The population declined 10% annually over the study period, which could lead to localized extinctions in less than 50 years.
Researchers found that female deer typically travel twice as far and take more convoluted paths than males, making it harder to contain chronic wasting disease. Dispersal rates are density-dependent, meaning higher deer densities lead to greater dispersal.
Researchers have found that two bile acids, ursodeoxycholic acid and tauroursodeoxycholic acid, can slow the progression of prion disease when given early in the disease process. These compounds bind to proteins causing disease and prevent them from spreading.
Researchers tested transgenic mice and rabbits for susceptibility to prions from various species, revealing that rabbits are susceptible to TSE after exposure to prions from other animals. The studies also showed that rabbit PRNP gene and its normal PrPC protein product do not provide absolute resistance to prion disease.
Scientists develop synthetic prions to study prion disease, demonstrating similarity with natural disease-causing prions. The researchers also explore the transmission capabilities of human prion mutations in mice, revealing the importance of expressing mutant human PrP for infection.
A study by University of Illinois researchers found that targeted deer culling in areas affected by CWD reduced the disease's prevalence to about 1% for 10 years. Meanwhile, hunter harvest increased nationwide, with only two counties experiencing a 11-20% reduction in deer populations.
Researchers Charles Weissmann and Adriano Aguzzi received the prestigious Hartwig Piepenbrock-DZNE Prize for their groundbreaking work on prion diseases. Their findings shed light on fundamental mechanisms of neurodegenerative disorders, including Alzheimer's and Parkinson's disease.
Researchers at the University of Alberta have made a breakthrough in understanding how prion diseases spread between different types of animals. By studying the adaptation process, they aim to determine why certain strains can infect one type of animal but not another.
Researchers found reducing copper in mice with prion disease delays onset by 20 days, with less abnormal protein in brains. However, study does not advocate for copper depletion as therapy and aims to learn more about copper function and prion disease biochemical workings.
Researchers found that prions can accumulate in the gut and infect the autonomic nervous system (ANS) before affecting the central nervous system (CNS). The study identified three possible routes for BSE prion ascension to the brain, shedding light on the pathogenesis of the disease.
Medical researchers have discovered a hidden process that erases the shadoo protein in infected brains, up to seven months before physical symptoms of prion diseases like BSE or mad cow disease appear. This new understanding opens up research opportunities into attenuating the disease.
USGS research suggests that certain lichens can break down the infectious proteins responsible for chronic wasting disease, a prion disease fatal to wild deer and elk. The study found that some lichen species contain a protease enzyme capable of significantly breaking down prions in the lab.
Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) have developed a highly sensitive blood test for detecting human prion diseases, which are fatal brain disorders. The new method improves upon previous tests by being 10,000 times more sensitive and can rapidly detect abnormal prion proteins in blood plasma.
Scientists have developed a process to turn meat and bone meal, once destined for landfills due to a government ban, into partially biodegradable plastic. The new material is durable and requires no raw materials from oil or natural gas.
Researchers at the Hertie Institute of Clinical Brain Research have found that peripheral administration of misfolded protein fragments can induce Alzheimer's-like brain pathology in mice. This discovery provides new clues on the underlying mechanisms of Alzheimer's disease and may lead to new strategies for prevention and treatment.
Researchers found that inflammasome activation increases muscle damage in muscular dystrophy, while galectin-7 expression levels are associated with metastasis in breast cancer. These findings provide new insights into disease mechanisms and potential therapeutic targets.
Researchers at CIC bioGUNE and Universidad de Kentucky have discovered a new method to control the stability of prions responsible for transmissible spongiform encephalopathies in deer. This finding has significant implications for controlling the epidemic affecting deer in the USA and Canada.
A 30-year-old man died of variant Creutzfeldt-Jakob disease (vCJD) with a unique genetic profile, highlighting potential cases with long incubation periods. His heterozygous PRNP gene may indicate silently infected individuals, posing concerns for public health.
A study in Zoonoses and Public Health confirms Chronix's potential for early disease detection, identifying signature sequences in serum DNA before clinical symptoms appear. The findings advance the company's ability to apply these results to laboratory tests for routine clinical use.
A genome-wide association study has identified two new genetic risk factors for variant Creutzfeldt–Jakob disease, including a SNP near the beta receptor for retinoic acid and a region close to STMN2. These findings suggest that genetic susceptibility plays a significant role in prion diseases.
A 9-year study in sheep found that the likelihood of BSE transmission via blood transfusion was 36% for BSE and 43% for scrapie. Researchers warn that up to 4,000 people could be carrying vCJD in the UK, posing a risk through infected blood.
A recent study found that blood transfusions can transmit a variant of mad cow disease (vCJD) to humans with high efficiency, particularly when donors are in the later stages of infection. The research suggests that blood from BSE- and scrapie-infected sheep could be used effectively in non-human experiments to develop diagnostic tests.
Amyloid fibrils, bundles of ordered protein filaments, display remarkable mechanical properties and have potential as nanomaterials. They can be tailored and biocompatible, making them suitable for surfaces in medical technology and drug delivery systems.
Researchers found that abnormally folded prion protein in brain tissue does not reliably predict disease infectivity; some highly infectious samples had nearly undetectable levels of abnormal PrP. This suggests alternative mechanisms or specific conformation of abnormal PrP may be responsible for prion diseases.
Researchers have developed an oral vaccine that can prevent mice from developing brain diseases similar to mad cow disease. The vaccine stimulates the immune system, resulting in delayed onset of symptoms even in mice with low antibody levels.
A study published in JCI Journal shows that silencing the PrPc gene suppresses BSE and CJD accumulation, offering a new approach to treat these fatal diseases. The therapy delayed PrPsc accumulation in mice, providing potential hope for individuals with neurodegenerative disorders.
A recent study reveals that prion disease infectivity can cause heart damage in mice, with similarities to human amyloid heart disease. The findings have significant implications for the development of new diagnostic tests and treatments for prion diseases.
Scientists at the University of Wisconsin-Madison discovered that certain soil types serve as natural prion repositories, potentially contributing to CWD transmission. The study found that prions bind tightly to montmorillonite clay and remain infectious after boiling in a detergent solution.
Researchers successfully engineered goat cells to silence prion protein genes, achieving over 90% knockdown. This breakthrough raises the possibility of using similar technology in cattle to prevent Mad Cow Disease and other diseases.
Scientists have developed a new method to catalogue and examine the differences between individual cases of prion diseases. Applying this assay to 50 postmortem samples from patients with sCJD reveals substantial differences in molecular pathology, which could help understand this mysterious disease.
Researchers have identified the PrPC protein as a crucial component in the neuronal metabolism of calcium, shedding new light on the cause of mad cow disease. The study found that prions damage perineuronal nests, leading to neuronal death and disease progression.
Researchers propose that human TSE-contaminated material was the cause of BSE, transmitted via animal feed, and originated from the Indian subcontinent. The study calls for global cooperation between public health, agriculture, and industry organizations to thoroughly investigate the sources of animal by-products.
Yun-Hwa Peggy Hsieh's patented immunoassay assays detect BSE and Scrape diseases in animal feeds, improving trade relations with China. Her Reveal Ruminant test kit has been widely adopted globally.
Scientists at the Salk Institute have discovered that a specific conformation of the prion protein is the infectious entity behind deadly prion diseases. By altering this shape, researchers may find a strategy to control these untreatable brain-wasting diseases.
Researchers at NYU Langone Health have developed the first mucosal prion vaccine that protects mice from developing prion disease by up to 500 days. The vaccine uses proteins found on disease-causing organisms and has shown promising results in preventing the progression of prion diseases.
A study published in Science found that prions, the infectious agents behind mad cow disease, can accumulate in organs such as the liver and pancreas in animals with chronic inflammation. The discovery suggests that the current risk classification for farm animal organs may need to be reassessed in animals suffering from inflammation.
Scientists studying prion diseases in mice found that preventing cell death does not stop the progression of neurological symptoms. Damage to synapses, critical for nerve cell communication, is instead linked to the disease.