Articles tagged with Endocrine Regulation
A study identified metabolic subgroups in diabetes-free Chinese adults to predict 3-year risk of developing diabetes and related complications. The low-risk subgroup had favorable metabolic profiles, while the high-risk subgroup showed poor glycemic control and increased risks of fatty liver disease and cardiovascular events.
A study published in Science reveals that microglia and the protein RANK are involved in regulating the hypothalamic-pituitary-gonadal axis, which controls fertility. The research found that suppressing RANK expression led to distorted reproductive function, including reduced sex hormones and hypogonadism.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
Research shows that infants of stressed mothers have an earlier and faster tooth eruption, with more teeth by six months of age. Cortisol levels during late pregnancy are associated with this accelerated process.
Researchers at the University of Tsukuba identified a peptide hormone called Capa that regulates calcium levels in fruit flies. The study found that Capa is secreted by specific neurons and acts on organs similar to vertebrate kidneys to mobilize calcium from stored reserves.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A study by Mount Sinai-Duke University identifies specific DNA variants in the DENND1A gene that increase testosterone production in PCOS patients. This finding could lead to new therapies targeting the genetic source of elevated testosterone levels in PCOS, which is a common condition affecting reproductive-age women.
The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.
Dr. Seymour Reichlin's remarkable career spanned five decades, marked by scientific excellence, mentorship, and generosity. His influence on neuroendocrinology has been profound, with ongoing contributions at age 100 revealing new insights into Alzheimer's disease and ecstatic mysticism.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
A team of scientists has successfully developed a novel platform for diabetes treatment utilizing bioink derived from pancreatic tissue and 3D bioprinting technology. The HICA-V platform replicates the structure and function of the human endocrine pancreas, supporting islet maturation and functional enhancement.
Researchers found that melatonin improves mitochondrial function, reduces cellular stress, and prevents programmed cell death, promoting the conversion of glycolytic to oxidative fibers in muscle tissue. This change optimizes energy production and protects against muscle deterioration caused by obesity and type 2 diabetes.
Dr. Seymour Reichlin's centennial celebration highlights his ongoing scientific impact, with recent collaborations yielding new insights into hormone therapies for cognitive enhancement and emotional homeostasis. His work has established neuroendocrinology as a distinct field, bridging neuroscience, endocrinology, and clinical medicine.
A study found that increasing ketones through a keto diet or supplements can change menstrual frequency and intensity in pre-menopausal women. The research suggests that the presence of ketones, rather than weight loss, may regulate women's health.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
Researchers find that unabsorbed dietary polyphenols can reduce the risk of type II diabetes by regulating blood glucose levels and appetite through secretion of gastrointestinal hormones. Polyphenol-mediated binding and activation of T2R promotes the release of incretins, which regulate insulin secretion and food intake.
The Joint Guideline provides guidance on diagnosing and treating GC-AI, a condition affecting at least 1% of the global population. The guideline aims to improve patient care and outcomes worldwide.
Researchers found widespread data gaps on environmental effects, emphasizing the need for updated information requirements in REACH legislation. They propose utilizing cross-species knowledge and grouping substances to increase understanding.
Extracellular RNAs have been found to play a significant role in intercellular communications, signaling homeostatic changes between origin and recipient cells. The term RNAkine has been proposed for these extracellular ncRNAs, highlighting their unique regulatory scale in biological processes.
Researchers have identified a novel therapeutic target for pelvic pain in endometriosis by focusing on the IL-1β pathway and its regulation via the JNK signaling pathway. This study suggests that JNK inhibitors may be effective in reducing neuroinflammation and alleviating symptoms of endometriosis-associated pain.
Researchers from Tokyo Medical and Dental University successfully generated functional parathyroid glands from mouse embryonic stem cells using blastocyst complementation. This breakthrough study demonstrates the potential for regenerating organs in vivo and provides a new treatment option for hypoparathyroidism.
Researchers at DTU Health Tech created a multi-levelled scaffold that enables near-perfect bone healing in just eight weeks, without using growth factors or endocrine factors and cells. The scaffold combines essential bone minerals with mechanical properties matching human bone compressive strength.
In a breakthrough study, researchers discovered that the neuropeptide DH31 regulates reproductive dormancy in insects, controlling juvenile hormone production. This finding could lead to the development of new technologies to control agricultural pests and infectious disease vectors.
Researchers found that four weeks of shift work-like patterns in female mice disrupted their biological clock and reduced fertility. The study suggests that circadian disturbances impact female fertility and may lead to future prevention strategies.
Researchers have found that the subfornical organ senses circulating parathyroid hormone (PTH) and modulates its peripheral level. PTH then alters bone metabolism and remodeling, highlighting a critical role of the brain-parathyroid-bone axis in maintaining bone homeostasis.
A mouse study suggests that a specific brain receptor, the leptin receptor, may be involved in the development of PCOS symptoms. Researchers found that mice exposed to excess androgens prenatally had improved estrous cycles and regulation of their menstrual cycles, offering potential therapeutic targets for people with PCOS.
A research team led by the University of Cincinnati's Atsuo Sasaki aims to understand how an enzyme regulates lysosomal function based on energy molecule GTP. This study could lead to new treatments for cancer, neurodegenerative diseases and anti-aging.
A UC Riverside study identifies how a Fragile X gene mutation contributes to premature ovarian failure, leading to early infertility. Researchers found that the mutation affects neurons regulating reproduction in the brain and ovaries, causing an increase in hormone production and faster secretion rates.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
Researchers at Helmholtz Munich discovered a new protein called Cited1 that plays a crucial role in regulating energy homeostasis and sensitivity to satiety hormones. The study found that females are better protected against obesity due to their higher levels of estrogens, which regulate energy metabolism through the hypothalamus.
Researchers found that individuals with CYP8B1 loss-of-function mutations have improved insulin sensitivity and better glucose regulation, reducing the risk of developing Type 2 diabetes. The study suggests a potential new treatment approach using bile acid modulators to target this gene.
Research reveals TBX3 as a fate determinant controlling hypothalamic KNDy neuron development and puberty onset. Multiple TBX3 mutants fail to form phase-separated condensates, leading to delayed puberty in UMS patients.
A study by Okayama University researchers found that neuromedin U (NMU) is involved in metabolic processes but its 'anti-hunger' function may not be crucial for rats. Unlike mice, NMU expression is restricted in the rat brain and does not suppress feeding behavior.
A study found that leptin stimulates liver fat export and lowers liver fat content in healthy men, suggesting a new approach for treating fatty liver disease. The findings imply that the brain plays a role in liver fat metabolism via the autonomic nervous system, opening up potential new treatment options.
A recent study by Texas Tech University Health Sciences Center researchers has shed light on the mechanisms of salt transport across membrane barriers. The findings have significant implications for treating cystic fibrosis, a disease caused by mutations in three types of sodium-potassium pumps.
A recent case study at Kobe University reports a 15-month recovery process for a patient with impaired ACTH secretion due to COVID-19. The research team successfully restored hormone levels through ACTH replacement therapy, and the patient's condition improved significantly after one year and a half.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
Researchers found that UVB phototherapy increases levels of romantic passion and aggression in both men and women. Exposure to sunlight affects the endocrine system's regulation of sexual hormones.
Top female athletes have higher testosterone levels, which enhance physical performance and raise questions about fairness in competition. The European Society of Endocrinology recommends a maximum testosterone level of 5.0 nmol/L for female athletic events to ensure competitive fairness.
A recent study found nearly 15% of ACA marketplace plans lack in-network specialists for at least one specialty. This inadequate coverage can lead to high out-of-pocket costs and adverse selection. The study highlights the need to enhance enforcement or update insurance regulations to improve patient access to affordable care.
A new study by UCSF researchers found that the tobacco industry secretly influenced pesticide regulations at the EPA and World Health Organization. The study analyzed internal tobacco company documents and discovered that the industry hired ex-agents to manipulate decision-making, staged a useless test on phosphine emissions, and conce...
The American Physiological Society recognized 12 prominent researchers with its 2003 Distinguished Lectureships, honoring their groundbreaking contributions to physiology. The awardees delivered lectures on April 11-14, 2003, at the Experimental Biology meeting.
This year, APS awarded several prestigious lectureships to outstanding researchers in physiology. The award winners include Allen Cowley, Pontus Persson, Adrian Morrison, and Albert Bennett, who will present their research on various topics including genomics, cardiovascular function, biomedical ethics, and more.
A Cedars-Sinai Medical Center study has discovered a molecular mechanism behind hormonal responses to stress, involving leukemia inhibitory factor (LIF) and its regulation of the pituitary gland. This finding provides new insights into the body's response to stress and sepsis.