Add BrightSurf on Google Email

We feed gut microbes sugar, they make a compound we need

Researchers at Kobe University discovered that gut microbes convert glucose into short-chain fatty acids when fed sugar, highlighting a new symbiotic relationship. This finding could lead to the development of novel therapeutics for regulating gut microbiota and their metabolites.

SourceKobe University·JournalCommunications Medicine·TypeExperimental study·DateMar 3, 2025

Scientists improve the equation in FDA guidance predicting drug interactions

Researchers have improved the FDA's equation for predicting drug interactions by addressing fundamental limitations and incorporating new models. The modified equation has shown a significantly increased accuracy of about 80%, which is expected to contribute to increasing the success rate of new drug development.

SourceInstitute for Basic Science·JournalClinical Pharmacology & Therapeutics·TypeComputational simulation/modeling·DateJan 12, 2023

Should clinicians reconsider standard therapy for gout?

A recent clinical trial found that low-dose benzbromarone was more effective in reducing blood urate levels in patients with renal urate underexcretion. The study showed that more participants in the benzbromarone group achieved the target blood urate level of < 6 mg/dL compared to those receiving febuxostat.

SourceWiley·JournalArthritis & Rheumatology·DateJul 7, 2022

Shrimp cocktails served in Japanese rivers

A study by Kyoto University found that migratory shrimp significantly enriched streams with nutrients, outperforming aquatic insects. The research highlights the crucial role of these small crustaceans in maintaining ecosystem balance and suggests integrating landscape management to support nutrient cycling.

SourceKyoto University·JournalOecologia·TypeExperimental study·DateJan 15, 2022

Mild autonomous cortisol secretion predominantly affects women, associated with risk for hypertension, diabetes

A cross-sectional study found that mild autonomous cortisol secretion (MACS) predominantly affects women, increasing the frequency and severity of hypertension and type 2 diabetes compared to nonfunctioning adrenal tumors. Patients with MACS carried an increased cardiometabolic burden similar to Cushing Syndrome, even without typical f...

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeObservational study·DateJan 3, 2022

Space-simulation study reveals sodium rhythms in the body

A new study in humans published by Cell Press reveals that sodium levels actually fluctuate rhythmically over the course of weeks, independent of salt intake. The study, which examined cosmonauts participating in space-flight simulation studies, challenges widely accepted assumptions about sodium balance.

SourceCell Press·JournalCell Metabolism·DateJan 8, 2013