Articles tagged with Hyperinsulinism
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A new study found a significant association between hyperinsulinemia and abnormal uterine bleeding, with body mass index playing a unique role. The study suggests that addressing insulin resistance and obesity may be key to preventing abnormal uterine bleeding.
A team at the University of Exeter has found genetic changes in a region that controls the activity of the genome, turning on or off genes, which led to the discovery of the cause of Congenital Hyperinsulinism. This breakthrough could unlock new causes of rare diseases and pave the way for improved treatments.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Researchers from Osaka University found that SARS-CoV-2 binds to a cell-surface protein whose expression is promoted by high blood insulin levels in older, obese, and diabetic individuals. Regulating blood insulin levels may help lower COVID-19 risk by reducing GRP78 expression.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
A review of nearly 500 patient cases shows that surgery can cure virtually all patients with focal congenital hyperinsulinism. Surgery also prevents complications in patients with the diffuse form, where defective insulin-producing cells occur throughout the pancreas.
Congenital hyperinsulinism is caused by a genetic mutation that leads to permanent activation of the GDH protein, resulting in excessive insulin production. This triggers chronic hypoglycaemia, brain damage, and intellectual retardation. A new study may pave the way for novel therapies, including a drug that inhibits the GDH accelerator.
A new test developed by researchers at the University of Manchester can identify congenital hyperinsulinism in some patients without known genetic causes. The test measures hormone levels and may influence treatment options, including avoiding pancreatic removal.
Researchers found that purified fish oils improved blood sugar levels in babies with congenital hyperinsulinism. The treatment, combined with standard medical care, has the potential to stabilize blood sugar levels and prevent long-term disabilities.
Researchers at the University of Exeter have developed a new genetic sequencing technology to identify novel mutations causing congenital hyperinsulinism. This breakthrough will enable clinicians to make more informed decisions about treatment, reducing the need for invasive procedures.
A pilot study found that an investigational drug called exendin-(9-39) controls blood sugar levels in people with congenital hyperinsulinism. The study showed promising results, suggesting the potential for a new medical treatment for children with this rare disease.
Researchers at University of Manchester discover new treatments for congenital hyperinsulinism by correcting gene defects in insulin-producing cells. The breakthrough has the potential to reverse cellular defects and pave way for new drugs, offering real hope for devastating condition.
Researchers have successfully treated congenital hyperinsulinism, a rare genetic disease causing insulin imbalance, using a peptide called exendin-(9-39) that blocks hormone receptor action. This could lead to an innovative medicine for children with this condition.
A genetic disorder causing hypoglycemia, congenital hyperinsulinism is linked to defects in insulin secretion by pancreatic cells. Mutations in the glutamate dehydrogenase gene impair enzyme sensitivity, leading to excessive insulin release and hypoglycemia.