Articles tagged with Insulin Signaling
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Researchers at Northern Arizona University are developing a breakthrough tool to detect early signs of Alzheimer's disease. The new technology uses microvesicles in the blood to identify biomarkers indicating improved neuroplasticity, which can help track the disease's progression.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
Research suggests flavonoids improve insulin sensitivity, enhance β-cell function, modulate the gut microbiota, inhibit gluconeogenesis, and regulate enteroendocrine hormones in type 2 diabetes management. Flavonoid-specific effects on GLP-1, GIP, PYY, and CCK secretion contribute to improved glycemic control.
A dynamic signaling network plays a crucial role in regulating insulin action in human muscle cells. The study reveals previously unknown mechanisms that could be used to treat type 2 diabetes, including the stimulation of specific enzymes and protein kinases.
Researchers found that administration of fish oil reduced insulin resistance and improved blood sugar levels in non-obese rats, reversing a condition similar to type 2 diabetes. The study suggests that omega-3 fatty acids may be a key factor in reducing inflammation and improving glucose metabolism.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
Researchers identified 14 proteins and 2 metabolites associated with prediabetes progression to diabetes, including DCXR and GSTA3. Inflammation and immune system pathways also play a key role in glucose homeostasis.
Researchers from Kumamoto University identified SerpinA1 as a key regulator in combating obesity and enhancing glucose metabolism. The study found that activating brown adipose tissue could pave the way for innovative treatments for diabetes and metabolic disorders.
A large study found that patients with diabetes taking GLP-1 receptor agonist drugs had lower rates of hospital readmission, wound re-opening, and hematoma after surgery. Improved blood sugar control was not the likely mediator, suggesting other mechanisms may be at play.
The study found that both axolotls and fruit flies exhibit distinct lipid adjustments during regeneration, with males increasing circulating lipids and females storing lipids in the liver. Insulin signaling pathways play a crucial role in adapting lipid metabolism to meet the needs of cell proliferation.
Research suggests that GLP-1 receptor agonists and SGLT2 inhibitors, commonly prescribed for Type 2 diabetes or weight loss, may lower the risk of heart attack and recurrent stroke in adults who have had an initial stroke. The study analyzed data from over 7,000 adults with ischemic strokes between 2000 and 2022.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
Researchers have made a breakthrough in understanding the GIP hormone's role in regulating insulin levels and weight loss. The study, involving over 500,000 individuals, found that inhibiting the GIP receptor may result in weight loss, while activating it without arresting its signal is crucial.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
The CCR4-NOT complex plays a crucial role in regulating RNA metabolism and stress response in C. elegans, compromising stress resistance and decreasing lifespan when depleted of subunits. This study highlights an important new role for the CCR4-NOT complex in normal aging and longevity.
In nerve cells, insulin facilitates the elimination of defective mitochondria when energy is available. However, during energy scarcity or disrupted insulin signaling, mitochondrial recycling is reduced, allowing potentially damaged power plants to continue operating. This process affects ageing processes and neurological diseases.
Groundbreaking research reveals changes in pancreatic beta cells at the onset of Type 1 Diabetes, identifying a novel mechanism for protection and a promising therapeutic target in mice and humans. Boosting levels of METTL3 enzyme may slow disease progression.
A Boston College biologist is studying the mechanisms of viral insulins to develop novel therapeutics for a range of human diseases, including cancers. The researcher has identified six viruses that mimic human insulin and IGF-1, which can block an important receptor, leading to potential affordable treatments.
Researchers from Pusan National University discovered a link between diabetes and periodontitis, showing pro-inflammatory cytokines rise in classical monocytes. The study highlights the systemic impact of these conditions on immune regulation and suggests a potential therapeutic target to reduce diabetes risk.
A new study published in the American Heart Association journal Hypertension found that tirzepatide significantly lowered systolic blood pressure levels in nearly 500 adults with obesity. The results suggest treating obesity with this weight loss medication may be an effective strategy for preventing or treating high blood pressure.
A Northwestern University study found that nearly two-thirds of patients discontinue or change their medication within a year, highlighting the need for better understanding of barriers to treatment adherence. The high discontinuation rate for GLP-1 RAs may be due to gastrointestinal side effects.
Researchers at Weill Cornell Medicine discovered a genetic variant in the GIP receptor that may help individuals resist obesity. The variant enhances insulin release and glucose metabolism, allowing mice with the variant to process sugar more efficiently and stay leaner.
A preclinical study by Weill Cornell Medicine researchers reveals that activating a pathway to promote cell division can expand insulin-producing cells without impairing their function. The study's findings support the concept that beta cell mass can be expanded without compromising function.
Researchers used behavioral and live brain imaging studies to understand why food-sated fruit flies avoid cooler temperatures. They found that insulin signaling modulators play a key role in regulating thermosensation under different feeding states.
Researchers developed a computational model to analyze glucose-responsive insulin (GRI) performance in human patients. The model predicted that differences in sugar receptor behavior between humans and lab animals led to the drug's poor effect in clinical trials. This breakthrough helps researchers design better GRIs, potentially reduc...
A comprehensive study reveals that genetics and diet significantly influence insulin signaling in skeletal muscle. The research identified thousands of novel phosphosites associated with insulin regulation and provided a unique tool for assessing phosphorylation in insulin reactions.
Researchers discovered that physical activity suppresses insulin-producing cells in fruit flies, allowing for efficient energy replenishment. This finding has implications for human health, as reduced insulin activity is linked to healthy ageing and longevity.
WEHI researchers have visualized how a non-insulin molecule can mimic the role of insulin, opening new avenues for an oral insulin pill. The study confirms alternative molecules can be used to turn on blood glucose uptake, bypassing insulin needs.
Researchers at Osaka University identified T-cadherin as a factor that feeds back a lack of insulin to pancreatic β cells, inducing their proliferation. This finding suggests a potential new treatment for diabetes by targeting T-cadherin.
A new study identified distinct metabolic profiles in women with Idiopathic Intercranial Hypertension (IIH), a condition characterized by raised brain pressure. Weight loss programs showed positive effects on results, suggesting that metabolism plays a role in disease development.
Queen ants live much longer than workers by generating an anti-insulin protein that blocks aging pathways. This protein enables pseudoqueens, female worker ants that become queens, to reproduce and live longer without aging.
A new study reveals that ant queens implement a dual-control system for insulin to promote egg development while slowing down the aging process. This unique mechanism allows ants to live longer and reproduce more effectively, unlike other animals.
Researchers have combined tesaglitazar and GLP-1 in a new hormone combination for type 2 diabetes treatment, improving glucose metabolism with minimal doses. The new drug has shown promise in animal studies, reducing kidney damage and increasing insulin sensitivity.
A new study reveals that the protein CHIP can regulate insulin receptor signals more efficiently alone than in a paired state. This finding suggests that maintaining a balance between monomeric and dimeric states of CHIP is crucial for proper cellular function.
A new study reveals that IL18 signaling is essential for β-cell development and insulin secretion, using specific receptors on acinar and β cells. This finding may provide insights into the role of IL18 in regulating islet β cell proliferation and guide future efforts to expand β cells and increase islet mass in diabetes.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
CHOP researchers have developed a targeted treatment that controls blood sugar in patients with hyperinsulinism, a genetic disease. The study found exendin-(9-39) reduces likelihood of fasting hypoglycemia by 76% and protein-induced hypoglycemia by 82%
Researchers at Lancaster University have identified a genetic change that impacts insulin signaling and glucose metabolism in the brain, which may lead to effective drug treatments for autism. The study found that individuals with a specific DNA deletion are more likely to develop neurodevelopmental disorders, including autism.
Researchers discovered a new hormone, fabkin, that regulates metabolism and controls insulin production in pancreatic beta cells. Blocking fabkin's activity prevented the development of both forms of diabetes in mice, suggesting its potential as a therapeutic target.
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
A genetic comparison of nearly two-thirds of the known species of rockfish pinpoints genes linked to their varying lifespans, which range from less than a decade to over 200 years. The study highlights trade-offs of long lifespan, including smaller populations and adaptations that increase survival
Research highlights the importance of normal insulin cycles for metabolic health, including better response to fed and fasted insulin inputs. It also uncovers mechanisms regulating robustness of insulin signaling, identifying potential novel regulatory components for therapeutic interventions.
Researchers at UC San Diego will use $6.4 million in NIH funding to study the influence of external signals on insulin production in beta cells. They aim to create a roadmap of genetic variations that can predict changes in insulin output, which may help prevent and treat diabetes.
Dopamine plays a key role in regulating blood glucose levels, and its blockade by antipsychotic medications can lead to uncontrolled glucose production and obesity. The study reveals that pancreatic alpha cells produce dopamine, which acts on both insulin-producing beta cells and other receptors.
Researchers have discovered a novel and druggable insulin inhibitory receptor named inceptor. Blocking its function leads to increased sensitisation of the insulin signalling pathway in pancreatic beta cells, allowing for potential protection and regeneration of beta cells for diabetes remission.
A novel 'disease-in-a-dish' model has been developed to study the basic molecular factors leading to type 2 diabetes. The model, using reprogrammed induced pluripotent stem cells from patients with type 2 diabetes and healthy controls, reveals defects in proteins with unknown roles in metabolism or diabetes.
Scientists have discovered a specific circular RNA that prolongs fruit fly lifespan by regulating the insulin signalling pathway. The circRNA, called circSulfateless, is expressed at higher levels in long-lived flies and can directly influence their lifespan. These findings suggest a potential link between circRNAs and human ageing.
Certain insects arrest their development at specific stages to cope with extreme conditions, a process known as overwintering. Research reveals that day length and temperature separately regulate this adaptation, utilizing distinct mechanisms including the juvenile hormone pathway and insulin/TOR signaling pathway.
Researchers found a truncated receptor called DAF-2B that acts as a decoy to capture insulin molecules, reducing insulin signaling. This discovery may offer new insights into insulin resistance, a feature of type 2 diabetes and aging.
A high-fat meal can disrupt communication between the intestine and the rest of the body through enteroendocrine cells, which produce hormones to signal digestion and nutrient absorption. The study found that these cells become overstimulated and exhausted after a high-fat meal, leading to silencing of their signals.
A common insulin signaling pathway has been found across cancer and diabetes, revealing the importance of protein TRAP-alpha in maintaining protein homeostasis. Deleting TRAP-alpha triggered a 90% reduction in insulin content in pancreatic beta cells, highlighting its role in insulin biogenesis.
Researchers have solved a critical piece of the puzzle by showing how insulin interacts with its receptor at a second binding site. This new understanding will allow researchers to design improved treatments for insulin-related disorders, such as diabetes.
Researchers identified insulin as a primary signal that helps communicate meal timing to the body clock, driving daily physiological rhythms. This discovery could lead to new therapies targeting insulin signaling and emphasize the importance of meal timing for maintaining healthy body clocks.
Researchers at Harvard Medical School discovered an unexpected mechanism by which insulin triggers changes to thousands of genes. The insulin receptor is physically transported to the cell nucleus and helps initiate the expression of insulin-related genes, providing new avenues for diabetes research and potential therapeutic targets.
Researchers at Joslin Diabetes Center found impaired insulin signaling in the brain negatively affects cognition, mood, and metabolism in Alzheimer's disease. The study used a novel mouse model to demonstrate the impact of disrupting insulin and IGF1 receptors on learning, memory, and mood.
Researchers at the Walter and Eliza Hall Institute have produced the first definitive 3D image of how insulin binds to its receptor on the surface of cells. This image could inform the design of faster-acting and longer-lasting insulin therapies, potentially benefiting millions worldwide.
University of Tokyo researchers have developed a trans-omics approach that maps the interactions between molecules inside cells in response to insulin. This comprehensive understanding may lead to better therapies for type 2 diabetes by identifying potential drug targets and optimizing insulin regimens.
Researchers at Toronto General Hospital have identified a specific insulin signaling pathway that revs up the response of T cells in the immune system, enabling them to divide rapidly and secrete cytokines. This finding opens avenues for better regulating the immune system and potentially developing new therapies.
A single gene, insulin-like peptide 2 (ilp2), regulates eusociality in ants by influencing reproductive cycles and division of labor. High expression of ilp2 in reproductive ants suggests a key role in the development of complex societies.
Research by Dr. Fernanda De Felice reveals a disease mechanism common to Alzheimer's disease and Type 2 diabetes, leading to new strategies for preserving brain health. The discovery identifies a pathway causing inflammation in the brain, affecting insulin signaling and endoplasmic reticulum stress.