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Mapping connections in a neuronal network

Harvard researchers have developed a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons. The chip has successfully mapped over 70,000 synaptic connections from approximately 2,000 rat neurons.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalNature Biomedical Engineering·TypeData/statistical analysis·DateFeb 13, 2025
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Unlocking richer intracellular recordings

A team of Carnegie Mellon University researchers has developed a novel microelectrode platform using 3D fuzzy graphene to enable richer intracellular recordings of cardiac action potentials. This advancement could revolutionize research on neurodegenerative and cardiac diseases, as well as the development of new therapeutic strategies.

SourceCollege of Engineering, Carnegie Mellon University·JournalScience Advances·DateApr 13, 2021

Up-close and personal with neuronal networks

Researchers have developed an electronic chip that can perform high-sensitivity intracellular recording from thousands of connected neurons simultaneously. This breakthrough has enabled the mapping of hundreds of synaptic connections and opens up new strategies for machine intelligence to build artificial neural networks.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalNature Biomedical Engineering·DateSep 23, 2019
Apple Watch Series 11 (GPS, 46mm)

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Intracellular recordings using nanotower electrodes

Researchers have developed nanoscale-tipped high-aspect-ratio vertical microneedle electrodes that can record neuronal signals from cells deep within biological tissues. These electrodes have a needle length exceeding 100 µm, allowing for deeper tissue penetration and expanding the range of applications in intracellular recording.

SourceToyohashi University of Technology (TUT)·JournalSmall·DateApr 8, 2016