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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

From bud to branch: How buds communicate to shape plant architecture

Researchers from the University of Cambridge have discovered a unified model that explains how plants control their architecture by integrating local and systemic signals. This breakthrough could help scientists design new strategies to optimize crop yield, resilience, and resource use.

Auxin signaling pathway controls root hair formation for nitrogen uptake

A study found that auxin signaling controls root hair elongation in response to nitrogen deficiency, enabling plants to explore soil resources more efficiently. This mechanism provides a new understanding of how plants adapt to low-nitrogen environments and offers potential breeding targets for improving crop nutrition.

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How a harmful fungus renders its host plant defenseless

A fungus called Ustilago maydis manipulates the corn plant's auxin signaling pathway by binding to a protein called Topless, suppressing certain pathways while promoting growth and division. This precise control enables the fungus to thrive in infected plants.

Molecular feedback-loop for plant growth

A molecular feedback-loop regulates plant growth by balancing high auxin levels, which stimulates cell division and elongation. The discovery involves PILS proteins that transport auxin into the endoplasmic reticulum, modulating its effect on plant development.

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Mathematics of plant leaves

A new mathematical model, EDC2, explains the peculiar 'orixate' leaf arrangement pattern of a Japanese plant, suggesting that older leaves have stronger inhibitory signals. The findings support the accuracy of the formula and shed light on the genetic and cellular machinery behind plant development.

Plant mothers talk to their embryos via the hormone auxin

Researchers find that a plant hormone called auxin from the mother plays a crucial role in regulating early embryo development in plants. The study, published in Nature Plants, reveals that increased maternal auxin production is necessary for normal embryo development and that auxin from the mother is essential for correct embryo growth.

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Communication via calcium wave

Scientists have identified a complex signal chain involving the auxin hormone and calcium channels in plant cells. Calcium waves are used to communicate local auxin signals over long distances, influencing root architecture and differentiation processes.

Auxin drives leaf flattening

Researchers discovered that auxin signaling defines the expression of genes WOX1 and PRS, which enable leaf blade expansion and flattening. This finding refines our understanding of auxin signaling in leaf development.

Unearthing key function of plant hormone

Researchers have discovered a key function of plant hormone auxin in regulating the organization of the cell's inner skeletons. Auxin interacts with transmembrane kinases to activate ROP GTPases, which affect cytoskeleton structure.

A place in the sun

Researchers at the Salk Institute discovered a key enzyme involved in auxin synthesis, which allows plants to stretch towards sunlight. This breakthrough could lead to increased crop yields by manipulating the plant's response to shade avoidance syndrome.

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Auxin takes root

Researchers have made significant advances in understanding the molecular pathway of root development by studying the auxin signaling pathway. The study identified a novel plant gene called NAC1, which is expressed in root tips and regulates the effect of auxin on root formation.