Articles tagged with Hog Pathway
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have engineered gut bacteria that dim their fluorescent glow in the presence of illness, allowing for early detection of gut conditions. The developed biosensor can provide continuous monitoring through stool samples and pick up subtle changes in gut health before symptoms develop.
Researchers investigate how hypernatremia affects microglial responses and evaluate potential therapies. Microglia's response to hyperosmotic stress is found to be associated with NFAT5 expression and NO production.
Researchers at Johns Hopkins Medicine have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells. The findings reveal what goes wrong when a group of molecules and enzymes trigger the cell cycle, leading to cancer development.
SMART researchers develop a nanosensor that selectively detects salicylic acid in live plants, vital for stress response. The sensor combines sensors for H₂O₂ and salicylic acid, enabling simultaneous monitoring of plant hormones and aiding in early diagnoses to improve crop resilience.
Researchers found that trehalose and glycogen pathways are crucial for stress tolerance in Pseudomonas aeruginosa, a significant pathogen causing pneumonia and hospital-acquired infections. Disrupting these pathways significantly reduced the bacteria's ability to survive on man-made surfaces.
Researchers discovered a new mechanism linking osmotic stress to the activation of autophagosomes and lysosomes, which play central roles in cellular recycling and degradation. The study provides insights into how environmental influences impact cellular processes and offers potential therapeutic avenues for neurodegenerative diseases.
Researchers at KAUST found that high salinity can protect corals from heat stress by increasing the levels of antioxidant floridoside. This compound helps regulate osmotic pressure and prevent severe bleaching in coral model organism Aiptasia.
Tiny plant cells in coral tissue produce osmolytes to regulate pressure, helping corals survive in salty waters. This finding has important implications for managing coral reefs under climate change.
Research reveals that cellular stress enhances Th17 cell activation, increasing the risk of autoimmune diseases such as arthritis and multiple sclerosis. Inhibiting cellular stress may hold promise for reducing disease symptoms by preserving other T cell responses.
Researchers have discovered how heat shock factor 1 (HSF1), a master transcriptional regulator, is activated and controlled by the on/off switch HSP70 and phosphorylation. This finding could lead to treatments for cancer and neurodegenerative diseases.
Researchers developed a novel sensor that changes color depending on the confinement of space in cells, demonstrating the effects of lack of space on protein behavior. The study reveals attractive forces inside cells that override compression effects, leading to changes in protein functions under osmotic stress.
Researchers have discovered a mechanism by which stress induces epigenetic changes in Drosophila that can be inherited across generations. The study found that the transcription factor dATF-2 plays a key role in this process, leading to changes in chromatin structure and gene expression.
A UCSD research team found that a specific transcription factor plays a crucial role in cells' ability to adapt to osmotic stress, which can lead to immune system dysfunction and cancer progression. The study's findings offer new possibilities for developing drugs to treat autoimmune diseases, transplant rejection, and cancer.