Articles tagged with Morphogen Signaling
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Researchers discovered that Wingless triggers cellular reorganization and contraction of tissue to form constrictions in the fly intestine. This finding expands our understanding of Wingless signalling pathway and its role in morphogenesis and organ development.
A team of researchers has developed a theoretical model forecasting the ideal body plan of a fruit fly's early embryo, indicating that evolution might have had many optimal options. The study suggests that optimization is a key driving force in nature, with biological systems often having multiple optimal solutions for the same problem.
Researchers at ISTA used miniature 2D organs and rubbery silicone molds to study morphogen signaling dynamics during spinal cord development. The study found that BMP morphogen signaling gradients emerge quickly, then fade away, only to reappear again, shedding light on the complex process of tissue development.
Researchers at St. Jude Children's Research Hospital have visualized how cytonemes transfer signals across vast distances during neural development, establishing an 'express route' for communication between cells. This discovery provides insights into the complex process of mammalian nervous system development and highlights the crucia...
A multidisciplinary team of scientists from UNIGE and MPIPKS has solved the mystery of how an organ changes its size depending on the size of the animal. They developed a mathematical equation that explains how cells know when to stop growing, using the example of the Paedocypris fish.
A study published in Nature Communications reveals that cell competition modulates morphogen gradients to eliminate unhealthy cells and maintain tissue patterning. The researchers found that aberrant Wnt/β-catenin signaling leads to changes in membrane expression levels of proteins, resulting in cell death via apoptosis.
A team of researchers has demonstrated that pure diffusion in a growing tissue is sufficient to explain the formation of a signaling gradient along the leaf proximal-to-distal axis. This finding provides evidence for the viability of the diffusion-based model of morphogen in developmental patterning of multicellular organisms.
A new study reveals the existence of a non-proliferative signaling center in tooth development, which drives epithelial invagination and instructs neighboring cells to proliferate. The initiation knot is identified as a critical regulator of tooth morphogenesis and size determination.
A study by North Carolina State University scientists has found that a cannibalistic tadpole's digestive organs can be transformed into those of a carnivorous frog using small molecules, revealing insights into the evolution and development of gut morphology. The research may also lead to better diagnosis and prevention of intestinal b...
Researchers have discovered that morphogen molecules move across cells via diffusion, a finding that could lead to new strategies for treating organ defects and cancers. The study used the fruit fly model to demonstrate how TGF beta family molecules function as morphogens.